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Effects of oral pantoprazole on 24-hour intragastric acidity and plasma gastrin profiles.

Author: BroomC, HannanA, WaltR P, WeilJ

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pantoprazole, a proton pump inhibitor, effectively reduces intragastric acidity in a dose-dependent manner. In a study involving 11 men, pantoprazole doses of 40 and 60 mg daily significantly increased median 24-hour gastric pH compared to placebo, with a higher effect observed with the higher dose.
Paper Details　
Original Abstract of the Article :
Pantoprazole selectively blocks gastric parietal cell H+,K(+)-ATPase. To define a dosage regimen for clinical trials we compared the effect of pantoprazole 40 and 60 mg daily on 24-h intragastric acidity and plasma gastrin concentrations using a double-blind, randomized, cross-over design. Eleven me...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.1992.tb00058.x

データ提供：米国国立医学図書館（NLM）

Pantoprazole: A Camel's Journey Through the Stomach's Acidic Desert

The human stomach is like a desert, with a harsh, acidic environment that helps break down food. However, sometimes this acidity becomes too strong, causing discomfort and digestive issues. Pantoprazole, a medication that blocks acid production in the stomach, is like a soothing oasis in this acidic desert, bringing relief and restoring balance.

This study, like a camel navigating a winding path through the desert, investigated the effects of different doses of pantoprazole on intragastric acidity and plasma gastrin levels. The researchers found that pantoprazole effectively reduced stomach acid levels, and the effect was dose-dependent. This suggests that pantoprazole can be a useful treatment for conditions like GERD, where excess stomach acid is a major factor.

Controlling Stomach Acid: A Camel's Quest for Balance

This research provides valuable information about the effectiveness of pantoprazole in reducing stomach acid levels. Finding the right dosage is crucial, like finding the perfect oasis in the desert. This study helps clinicians determine the appropriate dose for individual patients based on their specific needs.

Managing Digestive Health: A Camel's Tips for a Comfortable Journey

Maintaining a healthy digestive system is essential for overall well-being. This study offers insights into the mechanisms of stomach acid regulation and the role of pantoprazole in managing conditions like GERD. It's like finding a reliable water source in the desert - a solution that can bring relief and improve the quality of life.

Dr.Camel's Conclusion

This research sheds light on the effectiveness of pantoprazole in reducing stomach acid levels. By understanding the delicate balance of the stomach's internal desert, we can find ways to manage digestive issues effectively and improve our overall well-being. It's a reminder that just like a camel navigating a desert, we need to find the right balance to thrive in challenging environments.

Date :
  1. Date Completed 1992-07-10
  2. Date Revised 2019-08-27
Further Info :

Pubmed ID

1600053

DOI: Digital Object Identifier

10.1111/j.1365-2036.1992.tb00058.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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