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A clinical trial of trimethobenzamide/diphenhydramine versus sumatriptan for acute migraines.

Author: BijurPolly E, CorboJill, EssesDavid, FriedmanBenjamin W, GallagherE John, HochbergMichael, LiptonRichard B, PaternosterJoseph, SolorzanoClemencia, ToosiBabak

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

While various medications are used in the emergency department (ED) to treat acute migraines, none provide complete pain relief without side effects or headaches coming back. Even though anti-nausea medications and sumatriptan injections have shown effectiveness, there's still a need for better treatments given through injection. Early studies suggest that combining trimethobenzamide and diphenhydramine might be effective for a large percentage of migraine sufferers.
Paper Details　
Original Abstract of the Article :
Although various classes of medication are used to treat acute migraine in the emergency department (ED), no treatment offers complete pain relief without side effects or recurrence of headache. Consequently, even though several antiemetic medications as well as SQ sumatriptan have demonstrated effi...See full text at original site
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引用元：
https://doi.org/10.1111/j.1526-4610.2006.00467.x

データ提供：米国国立医学図書館（NLM）

Trimethobenzamide/Diphenhydramine vs. Sumatriptan for Migraines

The [emergency department (ED)] is often the battleground against the debilitating pain of [acute migraines]. This clinical trial compared the effectiveness of [trimethobenzamide/diphenhydramine (TMB/DPH)] and [sumatriptan] in treating acute migraines. The researchers aimed to identify a more effective and tolerable parenteral therapy for migraine relief in the ED setting.

TMB/DPH Shows Potential for Migraine Relief

The clinical trial explored the effectiveness of [trimethobenzamide/diphenhydramine (TMB/DPH)] and [sumatriptan] in treating [acute migraines]. The findings suggest that TMB/DPH may offer a viable alternative to sumatriptan for migraine relief in the ED. The study found that TMB/DPH provided effective pain relief in a significant proportion of migraineurs, highlighting its potential as a valuable treatment option in this setting.

Managing Migraine Pain

The study underscores the importance of exploring different treatment options for [acute migraines]. The findings suggest that [TMB/DPH] may offer a promising alternative to [sumatriptan] in the ED setting. If you are experiencing a migraine, it's crucial to seek medical attention to discuss the most appropriate treatment options and find relief from the debilitating pain.

Dr.Camel's Conclusion

This clinical trial offers valuable insights into the [treatment of acute migraines] in the [emergency department]. The findings suggest that [TMB/DPH] may be a promising alternative to [sumatriptan] for migraine relief, offering a potential solution for patients seeking effective and tolerable treatment options. This research underscores the importance of ongoing research to develop better and more personalized approaches to managing migraine pain.

Date :
  1. Date Completed 2006-08-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

16732839

DOI: Digital Object Identifier

10.1111/j.1526-4610.2006.00467.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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