Paper Details

  1. Home
  2. Paper Details

The effects of time and dose on the relative beta 1- and beta 2-adrenoceptor antagonism of betaxolol and atenolol.

Author: IrvineN A, LipworthB J, McDevittD G

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study compared the effects of beta-blockers betaxolol and atenolol on heart rate and other measures in healthy subjects. Beta-blockers reduced exercise heart rate in a dose-dependent manner. Betaxolol was more selective for beta1 receptors, meaning it had a greater effect on the heart than on the lungs.
Paper Details　
Original Abstract of the Article :
1. Six normal subjects were given single oral doses of betaxolol 10 mg (B10), 40 mg (B40), 80 mg (B80); atenolol 50 mg (A50), 200 mg (A200); or placebo (PL). Measurements of beta 1-adrenoceptor blockade (reduction of exercise heart rate) and of beta 2-adrenoceptor blockade (attenuation of isoprenali...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2125.1991.tb05504.x

データ提供：米国国立医学図書館（NLM）

Beta-Blockers: A Complex Dance in the Desert of Cardiology

This research delves into the [medical field: cardiology] realm, exploring the pharmacological characteristics of beta-blockers, specifically betaxolol and atenolol. The study utilizes [research methodology: pharmacological study] to investigate the beta 1- and beta 2-adrenoceptor antagonism of these medications at various doses. The authors conducted a study involving six healthy subjects, assessing the effects of different doses of betaxolol and atenolol on heart rate and other physiological parameters. The study provides insights into the dose-dependent effects of these medications and their selectivity for different beta-receptor subtypes.

A Complex Dance: Balancing Beta 1 and Beta 2

This research reveals the complex nature of beta-blockers, emphasizing the importance of understanding their dose-dependent effects and selectivity for different beta-receptor subtypes. The study demonstrates that both betaxolol and atenolol exhibit dose-related increases in beta 1- and beta 2-adrenoceptor antagonism, highlighting the need for careful consideration of dosage and individual patient characteristics when prescribing these medications.

Navigating the Desert of Beta-Blockers

Understanding the intricacies of beta-blockers is crucial for navigating their use effectively. This research highlights the importance of considering individual patient needs, potential side effects, and the appropriate dosage for each medication. Just as a traveler in the desert must adapt to changing conditions, healthcare providers must tailor beta-blocker therapy to individual patient needs to ensure safe and effective treatment.

Dr.Camel's Conclusion

This study offers valuable insights into the dose-dependent effects and receptor selectivity of beta-blockers, specifically betaxolol and atenolol. The research emphasizes the importance of understanding the complex interplay of these medications with the cardiovascular system. Just as a camel navigates the shifting sands of the desert, clinicians must carefully consider the individual needs of their patients when prescribing beta-blockers to ensure optimal treatment outcomes.

Date :
  1. Date Completed 1991-07-24
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

1675576

DOI: Digital Object Identifier

10.1111/j.1365-2125.1991.tb05504.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.