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Systemic effects of three beta-blocker eyedrops: comparison in healthy volunteers of beta 1- and beta 2-adrenoreceptor inhibition.

Author: HuguesF C, Le JeunneC, MuneraY

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Carteolol and timolol totally inhibited the beta 1 and beta 2 effects of isoproterenol, whereas betaxolol allowed the same effects with the same dose of isoproterenol.
Paper Details　
Original Abstract of the Article :
The beta 1- and beta 2-adrenoreceptor blockade by means of the systemic diffusion of three beta-blocker eyedrops--timolol, carteolol, and betaxolol--was evaluated in a randomized, single-blind, three-way crossover study in 18 volunteers. The blockade was evaluated by analyzing the variations of the ...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1990.78

データ提供：米国国立医学図書館（NLM）

Beta-Blocker Eyedrops: Systemic Effects on the Body

Beta-blockers, commonly used to treat conditions like high blood pressure and glaucoma, are often prescribed as eyedrops. This study investigates the systemic effects of three beta-blocker eyedrops, timolol, carteolol, and betaxolol, in healthy volunteers. The researchers measured the beta 1- and beta 2-adrenoreceptor blockade effects of these drugs, demonstrating that carteolol and timolol significantly inhibited both beta 1 and beta 2 effects, while betaxolol had a weaker effect.

Navigating Beta-Blocker Eyedrops: Understanding Systemic Effects

The study findings highlight the importance of considering the systemic effects of beta-blocker eyedrops, particularly for patients with pre-existing heart conditions or other health concerns. While these drugs are generally safe for most individuals, it's crucial to discuss potential risks and benefits with your doctor before using beta-blocker eyedrops.

Eye Care and Beyond: Understanding the Systemic Effects of Medications

This research underscores the importance of understanding the potential systemic effects of even seemingly localized treatments, such as eyedrops. Always consult with your doctor to discuss any potential risks and benefits of medications, ensuring that your overall health is taken into account.

Dr. Camel's Conclusion

This research, like a desert wind carrying subtle changes across the landscape, reminds us that even seemingly localized treatments can have broader systemic effects. When navigating the world of medications, it's essential to consider the whole picture, ensuring our health is well-protected, like a camel shielded from the harsh desert sun.

Date :
  1. Date Completed 1990-06-29
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

1971539

DOI: Digital Object Identifier

10.1038/clpt.1990.78

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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