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Effects of Vaccination with 10-Valent Pneumococcal Non-Typeable Haemophilus influenza Protein D Conjugate Vaccine (PHiD-CV) on the Nasopharyngeal Microbiome of Kenyan Toddlers.

Author: BashraheilMahfudh, FeazelLeah M, FrankDaniel N, HammittLaura L, RobertsonCharles E, SantoricoStephanie A, ScottJ Anthony G

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The nasopharyngeal microbiome (the community of microorganisms found in the nasal cavity) of children was studied to evaluate the impact of a pneumococcal vaccine on the overall bacterial diversity in the nasal cavity.
Paper Details　
Original Abstract of the Article :
Pneumococcal conjugate vaccines reduce the prevalence of vaccine serotypes carried in the nasopharynx. Because this could alter carriage of other potential pathogens, we assessed the nasopharyngeal microbiome of children who had been vaccinated with 10-valent pneumococcal non-typeable Haemophilus in...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471099/

データ提供：米国国立医学図書館（NLM）

The Impact of Pneumococcal Vaccines on the Nasopharyngeal Microbiome

Pneumococcal conjugate vaccines are incredibly effective at preventing pneumococcal infections, which can be as dangerous as a sandstorm in the desert! These vaccines work by reducing the number of pneumococcal bacteria that live in the nasopharynx, the area at the back of the nose and throat.

But what happens to the rest of the bacteria that live in the nasopharynx when these pneumococcal bacteria are reduced? This study investigated the impact of a 10-valent pneumococcal vaccine on the nasopharyngeal microbiome in Kenyan toddlers. The researchers wanted to understand if the vaccine might change the balance of bacteria in the nasopharynx, potentially affecting the risk of other infections. They found that the vaccine did indeed change the makeup of the microbiome, with some bacteria becoming more common and others becoming less common.

Understanding the Microbiome's Shifting Sands

This study reveals that the nasopharyngeal microbiome is a dynamic ecosystem, much like the shifting sands of a desert. Changes in the bacterial community can have important implications for health, and this research provides valuable insights into how vaccines can affect this delicate balance.

The Importance of Ongoing Research

The study highlights the need for ongoing research to monitor the long-term effects of pneumococcal vaccines on the nasopharyngeal microbiome. This research is like a long caravan journey through the desert – we need to continue to explore and learn as we go to ensure that these vaccines remain safe and effective.

Dr.Camel's Conclusion

This study reminds us that the world of bacteria is complex and interconnected. Vaccines can have a profound impact on our health, but we need to continue to study their effects to ensure that they are truly beneficial for everyone.

Date :
  1. Date Completed 2016-03-17
  2. Date Revised 2020-12-17
Further Info :

Pubmed ID

26083474

DOI: Digital Object Identifier

PMC4471099

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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