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Direct and Indirect Effectiveness of the 10-Valent Pneumococcal Conjugate Vaccine Against Carriage in a Cluster Randomized Trial.

Author: JokinenJukka, KaijalainenTarja, KilpiTerhi M, LahdenkariMika, NieminenHeta, PalmuArto A, SiiraLotta, SyrjänenRitva K, ToropainenMaija

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the direct and indirect effectiveness of a 10-valent pneumococcal conjugate vaccine (PHiD-CV10) in preventing pneumococcal carriage in children. The study found that PHiD-CV10 reduced vaccine-type carriage in both vaccinated children and their unvaccinated siblings. This is the first randomized trial to show the indirect effect of extended-valency pneumococcal conjugate vaccination on carriage.
Paper Details　
Original Abstract of the Article :
Finnish invasive pneumococcal disease (FinIP) vaccine trial was designed to evaluate effectiveness of 10-valent pneumococcal conjugate vaccine (PHiD-CV10; GSK; Rixensart, Belgium). We conducted 2 satellite studies to evaluate ten-valent Pneumococcal Haemophilus influenzae protein D conjugate vaccine...See full text at original site
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引用元：
https://doi.org/10.1097/INF.0000000000001705

データ提供：米国国立医学図書館（NLM）

Evaluating the Effectiveness of the 10-Valent Pneumococcal Conjugate Vaccine Against Carriage

This study evaluates the direct and indirect effectiveness of the 10-valent pneumococcal conjugate vaccine (PHiD-CV10) against pneumococcal carriage. The authors used data from a cluster randomized trial to assess the vaccine's effectiveness in vaccinated children and their unvaccinated siblings. This study evaluates the direct and indirect effectiveness of the 10-valent pneumococcal conjugate vaccine (PHiD-CV10) against pneumococcal carriage using data from a cluster randomized trial to assess the vaccine's effectiveness in vaccinated children and their unvaccinated siblings.

PHiD-CV10 Shows Promise in Reducing Pneumococcal Carriage

The study found evidence of both direct and indirect effectiveness of PHiD-CV10 against pneumococcal carriage. The vaccine significantly reduced vaccine-type carriage in vaccinated children and their unvaccinated siblings, suggesting a herd immunity effect. This study found evidence of both direct and indirect effectiveness of PHiD-CV10 against pneumococcal carriage, with the vaccine significantly reducing vaccine-type carriage in vaccinated children and their unvaccinated siblings, suggesting a herd immunity effect.

The Importance of Vaccination Programs for Public Health

This study highlights the importance of vaccination programs in reducing the burden of pneumococcal disease. The findings support the use of pneumococcal conjugate vaccines to protect individuals and communities from this serious infection.

Dr.Camel's Conclusion

This study, like a caravan traversing a vast desert, highlights the power of vaccination to protect individuals and communities. The researchers discovered that the 10-valent pneumococcal conjugate vaccine, like a refreshing oasis, significantly reduces pneumococcal carriage, both directly in vaccinated individuals and indirectly through herd immunity. This research emphasizes the importance of vaccination programs in safeguarding public health.
Date :
  1. Date Completed 2018-01-11
  2. Date Revised 2018-01-11
Further Info :

Pubmed ID

28737627

DOI: Digital Object Identifier

10.1097/INF.0000000000001705

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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