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Classics in Chemical Neuroscience: Selegiline, Isocarboxazid, Phenelzine, and Tranylcypromine.

Author: EstévezRyan F, GillmanPeter K, HoffmanGavin R, OlsonMadeline G, SchoffstallAllen M, StabioMaureen E, Van den EyndeVincent

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the history, pharmacology, and clinical use of four "classic" monoamine oxidase inhibitors (MAOIs): selegiline, isocarboxazid, phenelzine, and tranylcypromine. These drugs have been used in the treatment of several pathologies, including depression, Parkinson's disease, Alzheimer's disease, and various cancers. While MAOIs once enjoyed widespread use, they have dwindled in popularity due to side effects and food-drug interactions. A recent prescriber's guide for the use of MAOIs in treating depression has led to a resurgence in their use.
Paper Details　
Original Abstract of the Article :
The discovery of monoamine oxidase inhibitors (MAOIs) in the 1950s marked a significant breakthrough in medicine, creating a powerful new category of drug: the antidepressant. In the years and decades that followed, MAOIs have been used in the treatment of several pathologies including Parkinson's d...See full text at original site
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引用元：
https://doi.org/10.1021/acschemneuro.3c00591

データ提供：米国国立医学図書館（NLM）

The Journey of MAOIs: A Historic Look at Antidepressants

The discovery of monoamine oxidase inhibitors (MAOIs) in the 1950s revolutionized the treatment of depression, ushering in a new era of antidepressant medications. This research revisits the four classic MAOIs: selegiline, isocarboxazid, phenelzine, and tranylcypromine, exploring their chemical properties, pharmacological actions, and historical significance. Imagine a vast desert of mental health, where MAOIs are like ancient oases that have provided relief for those struggling with depression.

A Historical Journey Through the Desert of Depression

This research delves into the history of MAOIs, tracing their evolution from their discovery to their current role in treating depression. The paper examines the chemical structure, metabolism, and pharmacological properties of these classic MAOIs, highlighting their unique mechanisms of action. It is a journey through time, exploring the evolution of knowledge and understanding in the field of depression treatment.

Navigating the Desert of Medication Choices

While MAOIs have been overshadowed by newer antidepressant classes, such as tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs), their unique properties and potential benefits continue to make them relevant in certain cases. This research serves as a reminder of the importance of considering the full range of treatment options for depression and understanding the individual characteristics of each medication. It is like navigating a vast desert of medication choices, where each oasis offers unique benefits and challenges.

Dr.Camel's Conclusion

This review provides a valuable historical perspective on MAOIs, reminding us of their significant role in the evolution of antidepressant medications. The research highlights the importance of understanding the unique characteristics and potential benefits of MAOIs, particularly in the context of modern treatment options for depression.

Date :
  1. Date Completed 2023-12-07
  2. Date Revised 2023-12-07
Further Info :

Pubmed ID

37966854

DOI: Digital Object Identifier

10.1021/acschemneuro.3c00591

SNS
PICO Info
in preparation
Languages

English

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