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Controlled trial of trimipramine, monoamine oxidase inhibitors, and combined treatment in depressed outpatients.

Author: HughesW C, LaderM H, YoungJ P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 135 patients with mild or moderate depression found that trimipramine (a tricyclic antidepressant) was more effective than MAOIs (phenelzine or isocarboxazid) or a combination of the two. Trimipramine was particularly effective for patients with dizziness, suicidal thoughts, irritability, insomnia, and longer duration of illness. Side effects were not a major concern in any group.
Paper Details　
Original Abstract of the Article :
A study was carried out in which 135 mildly or moderately depressed outpatients were randomly allocated to one of five groups receiving six weeks' treatment weith antidepressant drugs. The groups received a tricyclic antidepressant (trimipramine; mean dose 106 mg at night) or a monoamine oxidase inh...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.2.6201.1315

データ提供：米国国立医学図書館（NLM）

The Camel Race of Antidepressants: Trimipramine vs. MAOIs

This research embarks on a journey through the vast and complex landscape of [depression], a condition that can feel like a never-ending desert trek. It compares the efficacy and safety of [trimipramine], a tricyclic antidepressant, to [monoamine oxidase inhibitors (MAOIs)], a different class of antidepressants, in treating mild to moderate depression.

The Tricyclic Triumph: A Clear Winner

The study found that trimipramine was consistently superior to MAOIs and combination treatments in reducing depressive symptoms. This suggests that trimipramine may be a more effective option for some individuals with mild to moderate depression. This is like having a camel that can navigate a desert faster and more efficiently than others, reaching the oasis of recovery sooner.

The Importance of Personalized Treatment

This research highlights the importance of personalized treatment approaches for depression. The study found that different antidepressants can be more effective for individuals with specific symptoms and characteristics. This underscores the need for careful evaluation and collaboration between patients and healthcare providers to identify the most appropriate treatment option.

Health Implications and Everyday Life

Depression is a common and often debilitating condition. If you are experiencing symptoms of depression, it's crucial to seek professional help. There are a variety of treatment options available, and finding the right one can make a world of difference in your well-being. This research serves as a reminder that effective treatment for depression can lead to a more fulfilling and happy life.

Dr.Camel's Conclusion

This research sheds light on the complex landscape of depression treatment, highlighting the importance of finding the right medication for the right person. It's a reminder that even in the face of a challenging condition like depression, there are options available to help people feel better and live healthier, more fulfilling lives.
Date :
  1. Date Completed 1980-03-24
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

391342

DOI: Digital Object Identifier

10.1136/bmj.2.6201.1315

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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