Paper Details

  1. Home
  2. Paper Details

Diacetyl derivative of nadolol. I. Ocular pharmacology and short-term ocular hypotensive effect in glaucomatous eyes.

Author: AndersonJ, BlumenthalM, ChenC C, DuzmanE, TwizerH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Diacetyl nadolol was more easily absorbed into ocular tissue than nadolol and was effective in reducing intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Paper Details　
Original Abstract of the Article :
On topical application to rabbit eyes, the diacetate ester of nadolol was more easily absorbed into ocular tissue than nadolol and was enzymatically hydrolyzed to nadolol within the eye. In a 24-hour clinical study, the ocular hypotensive activities of 0.5% diacetyl nadolol, 2% diacetyl nadolol, 2% ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1001/archopht.1982.01030040896005

データ提供：米国国立医学図書館（NLM）

Investigating the Ocular Hypotensive Potential of Diacetyl Nadolol

This research delves into the world of ocular pharmacology, focusing on the potential of diacetyl nadolol as a treatment for glaucoma. The study compares the effectiveness of diacetyl nadolol with other known glaucoma medications, assessing its ability to lower intraocular pressure (IOP). The authors' findings suggest that diacetyl nadolol may be a viable option for the management of glaucoma, particularly in the early stages of the disease.

A New Oasis in Glaucoma Treatment?

The study demonstrates that diacetyl nadolol exhibits significant IOP-lowering effects in the early stages of glaucoma. These findings suggest that this drug could be a promising alternative or complement to current treatment options for this debilitating condition.

Maintaining Vision Clarity: A Desert Oasis of Hope

The study highlights the potential benefits of diacetyl nadolol for individuals with glaucoma. This research offers hope for the development of new and effective treatments to combat this eye disease, which can lead to vision loss if left untreated. Maintaining clear vision is crucial, much like the camel's ability to see its way across the vast desert. This research offers a glimmer of hope for a brighter future for those living with glaucoma.

Dr. Camel's Conclusion

This research highlights the potential of diacetyl nadolol as a novel treatment option for glaucoma. The study's findings suggest that this drug could provide a valuable tool for managing IOP in the early stages of the disease. Further research is warranted to fully explore the efficacy and safety of diacetyl nadolol for glaucoma treatment. This research reminds us that the search for new treatments is a continuous journey, akin to a camel's tireless trek across the desert in search of oases.
Date :
  1. Date Completed 1983-01-19
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

6756362

DOI: Digital Object Identifier

10.1001/archopht.1982.01030040896005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.