Effects of naltrexone and bupropion: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major Research Findings

Nadolol, a long-acting nonselective beta-adrenoblocker, has been shown to be more effective than propranolol in lowering blood pressure and heart rate in patients with stable arterial hypertension. 2 Nadolol has a favorable effect on blood pressure and heart rate, making it a suitable treatment option for patients with stable arterial hypertension. 2 Nadolol has been shown to effectively reduce intraocular pressure (IOP) in normal volunteers, with a dose-dependent effect observed. 3 The diacetyl derivative of nadolol, when applied topically to the eyes of glaucoma patients, showed a significant reduction in IOP, although it was less effective than timolol. 7 Nadolol eye drops have demonstrated dose-dependent IOP reduction and prolonged duration of action in glaucoma and ocular hypertension patients. 6 The diacetate ester of nadolol is more easily absorbed into ocular tissue compared to nadolol, with the potential to be hydrolyzed to nadolol within the eye, suggesting a possible role in glaucoma treatment. 8 Oral administration of nadolol has been shown to lower IOP in normal volunteers. 5 Nadolol has proven effective in reducing IOP compared to topical timolol, while also demonstrating a more pronounced reduction in heart rate. 4 Nadolol has demonstrated efficacy in the treatment of angina pectoris, showing similar effectiveness to propranolol in reducing anginal attacks and nitroglycerin usage. 1

Benefits and Risks

Benefits Summary

Nadolol demonstrates potential benefits in the treatment of various conditions, including hypertension, glaucoma, ocular hypertension, and angina pectoris. Its once-daily administration schedule offers convenience for patients.

Risks Summary

Nadolol may cause side effects such as decreased heart rate and blood pressure. 2 While effective in lowering IOP, its easy absorption into ocular tissue and subsequent conversion to nadolol within the eye raise potential concerns for ocular side effects. 8

Comparison Across Studies

Commonalities

The studies consistently evaluated the effectiveness of nadolol in managing various conditions like hypertension, glaucoma, and angina pectoris. These findings suggest the potential of nadolol as a therapeutic option.

Differences

The studies varied in terms of patient populations, treatment durations, and study designs. This highlights the need for further research to determine the optimal dosage, administration methods, and potential side effects of nadolol.

Consistency and Contradictions in Results

The research demonstrates consistent evidence for nadolol's potential effectiveness in managing various conditions. However, inconsistencies exist regarding optimal dosage, administration methods, and potential side effects, requiring further investigation.

Practical Applications and Considerations

While nadolol holds promise for treating various conditions, consultation with a healthcare professional is crucial to determine the appropriate dosage, administration, and management of potential side effects. 2 3 7 6 8 5 4 1

Limitations of Current Research

The existing studies are limited by their relatively small size and short durations. Further research is needed to evaluate the long-term safety and efficacy of nadolol.

Directions for Future Research

Larger and longer-term studies are required to assess the long-term safety and efficacy of nadolol. Additional research is necessary to determine the optimal dosage, administration methods, and potential side effects of nadolol for different patient populations and conditions. 2 3 7 6 8 5 4 1

Conclusion

The research provides consistent evidence for nadolol's potential effectiveness in treating hypertension, glaucoma, ocular hypertension, and angina pectoris. However, further investigation is required to optimize dosage, administration methods, and address potential side effects. It is essential for healthcare professionals to consult with patients and carefully consider the risks and benefits of nadolol before prescribing it. 2 3 7 6 8 5 4 1

Literature analysis of 8 papers
Positive Content
8
Neutral Content
0
Negative Content
0
Article Type
8
0
0
0
8
1.

Angina pectoris: effective therapy once daily.

Author: PragerG

Angina treatment
Mild side effects

Nadolol and propranolol, both beta-blockers, were compared in treating anginal patients. Both medications had similar effects on anginal attacks and nitroglycerin usage, but nadolol resulted in better exercise performance. Nadolol also maintained its positive effects during extended treatment periods. No serious side effects or lab abnormalities were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[The comparative results of a short course of nadolol and propranolol treatment of arterial hypertension patients (cooperative research). The Working Group of the Cooperative Program for the Study of New Preparations in Preventing Arterial Hypertension].

Author:

Hypertension treatment
Once-daily dosing
Decreased glomerular filtration

Nadolol, a long-acting beta-blocker, was more effective and convenient than propranolol in controlling hypertension. It did not significantly affect glomerular filtration at lower doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

3.

Effect of orally administered nadolol on the intraocular pressure in normal volunteers.

Author: WilliamsonJ, AttaH R, KennedyP A, MuirJ G

Reduced blood pressure
Reduced heart rate
Reduced intraocular pressure
Beta blocker therapy
Side effects

Oral nadolol significantly reduced intraocular pressure in a dose-dependent manner. Blood pressure and heart rate also decreased but to a lesser extent. The results suggest potential for nadolol in treating chronic simple glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparison of the effects of oral nadolol and topical timolol on intraocular pressure, blood pressure, and heart rate.

Author: DuffG R, WattA H, GrahamP A

Effective glaucoma treatment
Lower intraocular pressure
Lower heart rate

Nadolol and timolol, both eye pressure-lowering medications, were compared in a study of glaucoma suspects. Both drugs reduced eye pressure effectively, but nadolol caused a greater reduction in heart rate than timolol. Nadolol may be a useful alternative for treating glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The effect of a once-daily oral dose of nadolol on intraocular pressure in normal volunteers.

Author: RennieI G, SmerdonD L

Reduced intraocular pressure
Minimal side effects

Nadolol, a beta-blocker, was found to significantly decrease intraocular pressure in healthy volunteers. Both 20 mg and 40 mg doses were effective, with the higher dose providing longer-lasting effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Nadolol eye drops in glaucoma and ocular hypertension: a controlled clinical study of dose response and duration of action.

Author: KrieglsteinG K

IOP reduction
Nadolol efficacy

Nadolol eye drops effectively reduced intraocular pressure in a dose-dependent manner, with a duration of action exceeding 6 hours for 0.3% and 9 hours for 1.5% and 2% concentrations. No significant effects on blood pressure, heart rate, or ocular irritation were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Diacetyl nadolol: 3-month ocular hypotensive effect in glaucomatous eyes.

Author: DuzmanE, RosenN, LazarM

Lowers intraocular pressure
Periorbital dermatitis
Tolerance

Timolol was more effective than diacetyl nadolol in lowering intraocular pressure in patients with glaucoma. Diacetyl nadolol caused periorbital dermatitis in two patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Diacetyl derivative of nadolol. I. Ocular pharmacology and short-term ocular hypotensive effect in glaucomatous eyes.

Author: DuzmanE, ChenC C, AndersonJ, BlumenthalM, TwizerH

Intraocular pressure reduction

Diacetyl nadolol was more easily absorbed into ocular tissue than nadolol and was effective in reducing intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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