Effects of nadolol: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major Research Findings

Nadolol has been shown to be an effective treatment for high blood pressure, angina, and glaucoma in multiple studies. 2 , 1 , 3 These studies indicate that nadolol effectively lowers blood pressure, reduces the number of angina attacks, improves exercise capacity, and lowers intraocular pressure. Nadolol, compared to propranolol, can be taken once daily and has a longer-lasting effect. 2 , 1 Furthermore, nadolol has been shown to reduce intraocular pressure, making it a promising treatment for glaucoma and patients with high eye pressure. 3 , 6 , 8 , 4 , 5 , 7

Benefits and Risks

Benefits Summary

Nadolol is an effective medication for the treatment of high blood pressure, angina, and glaucoma. It has been shown to effectively lower blood pressure, reduce the number of angina attacks, improve exercise capacity, and lower intraocular pressure. Nadolol, compared to propranolol, has the advantage of being taken once daily and having a longer-lasting effect.

Risk Summary

Like other medications, nadolol carries the risk of side effects. Common side effects include dizziness, fatigue, headache, nausea, and constipation. Serious side effects include heart failure, hypoglycemia, difficulty breathing, and liver damage. Nadolol should be used with caution in patients with a history of heart disease, asthma, and pregnant or breastfeeding women.

Comparison of Studies

Commonalities of Studies

Multiple studies have shown that nadolol improves blood pressure, the number of angina attacks, exercise capacity, and intraocular pressure.

Differences in Studies

Due to variations in nadolol administration method, dosage, assessment criteria, and study duration among studies, direct comparison is challenging. However, nadolol has been shown to be effective in numerous studies.

Consistency and Contradictions of Results

While multiple studies have demonstrated nadolol's effectiveness and safety, some studies suggest that at certain doses, nadolol may impair kidney function. 2

Considerations for Real-World Applications

It is crucial to take nadolol as directed by your doctor. Do not stop or adjust your dosage without consulting your doctor. Nadolol may interact with other medications, so if you are taking other medications, talk to your doctor.

Limitations of Current Research

Further research on the long-term effects of nadolol is needed. Additionally, more information about nadolol's side effects is necessary.

Future Research Directions

Studies are needed to evaluate the long-term effects of nadolol. It is also crucial to further investigate nadolol's side effects.

Conclusion

Nadolol is an effective medication for the treatment of high blood pressure, angina, and glaucoma. However, it is essential to understand the potential risks. Take nadolol safely as directed by your doctor.

Literature analysis of 8 papers
Positive Content
8
Neutral Content
0
Negative Content
0
Article Type
8
0
0
0
8
1.

Angina pectoris: effective therapy once daily.

Author: PragerG

Angina treatment
Mild side effects

Nadolol and propranolol, both beta-blockers, were compared in treating anginal patients. Both medications had similar effects on anginal attacks and nitroglycerin usage, but nadolol resulted in better exercise performance. Nadolol also maintained its positive effects during extended treatment periods. No serious side effects or lab abnormalities were reported.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[The comparative results of a short course of nadolol and propranolol treatment of arterial hypertension patients (cooperative research). The Working Group of the Cooperative Program for the Study of New Preparations in Preventing Arterial Hypertension].

Author:

Hypertension treatment
Once-daily dosing
Decreased glomerular filtration

Nadolol, a long-acting beta-blocker, was more effective and convenient than propranolol in controlling hypertension. It did not significantly affect glomerular filtration at lower doses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

3.

Effect of orally administered nadolol on the intraocular pressure in normal volunteers.

Author: WilliamsonJ, AttaH R, KennedyP A, MuirJ G

Reduced blood pressure
Reduced heart rate
Reduced intraocular pressure
Beta blocker therapy
Side effects

Oral nadolol significantly reduced intraocular pressure in a dose-dependent manner. Blood pressure and heart rate also decreased but to a lesser extent. The results suggest potential for nadolol in treating chronic simple glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A comparison of the effects of oral nadolol and topical timolol on intraocular pressure, blood pressure, and heart rate.

Author: DuffG R, WattA H, GrahamP A

Effective glaucoma treatment
Lower intraocular pressure
Lower heart rate

Nadolol and timolol, both eye pressure-lowering medications, were compared in a study of glaucoma suspects. Both drugs reduced eye pressure effectively, but nadolol caused a greater reduction in heart rate than timolol. Nadolol may be a useful alternative for treating glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The effect of a once-daily oral dose of nadolol on intraocular pressure in normal volunteers.

Author: RennieI G, SmerdonD L

Reduced intraocular pressure
Minimal side effects

Nadolol, a beta-blocker, was found to significantly decrease intraocular pressure in healthy volunteers. Both 20 mg and 40 mg doses were effective, with the higher dose providing longer-lasting effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Nadolol eye drops in glaucoma and ocular hypertension: a controlled clinical study of dose response and duration of action.

Author: KrieglsteinG K

IOP reduction
Nadolol efficacy

Nadolol eye drops effectively reduced intraocular pressure in a dose-dependent manner, with a duration of action exceeding 6 hours for 0.3% and 9 hours for 1.5% and 2% concentrations. No significant effects on blood pressure, heart rate, or ocular irritation were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Diacetyl nadolol: 3-month ocular hypotensive effect in glaucomatous eyes.

Author: DuzmanE, RosenN, LazarM

Lowers intraocular pressure
Periorbital dermatitis
Tolerance

Timolol was more effective than diacetyl nadolol in lowering intraocular pressure in patients with glaucoma. Diacetyl nadolol caused periorbital dermatitis in two patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Diacetyl derivative of nadolol. I. Ocular pharmacology and short-term ocular hypotensive effect in glaucomatous eyes.

Author: DuzmanE, ChenC C, AndersonJ, BlumenthalM, TwizerH

Intraocular pressure reduction

Diacetyl nadolol was more easily absorbed into ocular tissue than nadolol and was effective in reducing intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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