Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine.

Author: BrysonY J, DreisbachM, MilletV M

Paper Details 
Original Abstract of the Article :
A total of 52 healthy, adult volunteers were randomly assigned to five treatment groups to be treated twice daily for 4 days with 100 mg of amantadine, 100 mg of rimantadine, 4 mg of chlorpheniramine or placebo alone, or 100 mg of amantadine in combination with chlorpheniramine. The results of tests...See full text at original site
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引用元:
https://doi.org/10.1128/AAC.21.1.1

データ提供:米国国立医学図書館(NLM)

Amantadine, Rimantadine, and Chlorpheniramine: Navigating the Central Nervous System Desert

Antiviral medications are often used to combat viral infections, but they can sometimes have unintended effects on the central nervous system, like a camel encountering a mirage in a desert landscape. This double-blind controlled study, like a careful observer navigating a complex terrain, investigated the central nervous system side effects of amantadine, rimantadine, and chlorpheniramine. The researchers aimed to understand the potential cognitive and behavioral effects of these medications, hoping to ensure their safe and effective use.

Minimal Side Effects: A Smooth Journey Through the Desert

This study, like a caravan traversing a desert with a steady and reliable guide, found that amantadine, rimantadine, and chlorpheniramine had minimal side effects on cognitive function. The researchers discovered that these medications, while potentially impacting the central nervous system, did not significantly impair cognitive performance or lead to significant subjective side effects. It's like a journey through a desert landscape, where the terrain is challenging but ultimately manageable.

Navigating the Central Nervous System with Caution

This research emphasizes the importance of carefully monitoring the central nervous system effects of antiviral medications. It's like a traveler recognizing the need for caution when traversing an unfamiliar desert landscape. The researchers' findings suggest that while these medications are generally well-tolerated, they may still have some impact on the central nervous system. Further research is needed to fully understand the nuances of these effects and to ensure the safe and effective use of these medications.

Dr. Camel's Conclusion

This study provides valuable insights into the central nervous system effects of amantadine, rimantadine, and chlorpheniramine. The researchers found that these medications are generally well-tolerated and do not significantly impair cognitive function. However, it's important to exercise caution when using these medications, recognizing that they may still have some impact on the central nervous system.

Date :
  1. Date Completed 1982-07-08
  2. Date Revised 2021-05-26
Further Info :

Pubmed ID

7044294

DOI: Digital Object Identifier

10.1128/AAC.21.1.1

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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