Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. Pediatric Oncology Group.

Author: CamittaB, CarrollA, ChangM N, Graham-PoleJ, InoueS, KrischerJ, RavindranathY, SteuberC P, WeinsteinH J, YeagerA M

Paper Details 
Original Abstract of the Article :
BACKGROUND: The value of autologous bone marrow transplantation in the treatment of children with acute myeloid leukemia (AML) is unknown. We compared autologous bone marrow transplantation with intensive consolidation chemotherapy as treatments for children with AML in first remission. METHODS: We...See full text at original site
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引用元:
https://doi.org/10.1056/NEJM199605303342203

データ提供:米国国立医学図書館(NLM)

Bone Marrow Transplant vs. Intensive Chemotherapy for Childhood AML

Acute myeloid leukemia (AML) is a serious condition, especially for children. This study explores the effectiveness of two treatment approaches for children with AML in first remission: autologous bone marrow transplantation and intensive consolidation chemotherapy. The researchers conducted a [research methodology] to compare the outcomes of these two treatment strategies. It's like navigating a desert with two different paths, each with its own challenges and rewards.

Similar Outcomes for Two Distinct Treatment Approaches

The study found that both autologous bone marrow transplantation and intensive consolidation chemotherapy resulted in similar rates of event-free survival and overall survival at three years. It's like reaching the same oasis, even though the journey was taken on different paths. While the relapse rate was lower in the bone marrow transplant group, there was a higher rate of treatment-related mortality.

Finding the Right Path for Pediatric AML

This research highlights the need for careful consideration when choosing treatment strategies for children with AML. It's like choosing the path that best suits the individual's needs and circumstances. The study emphasizes that the choice of treatment should be based on a thorough assessment of individual factors and potential risks and benefits.

Dr. Camel's Conclusion

This study provides valuable insights into the treatment of childhood AML. It demonstrates that there is not one universally best path, but rather a range of options to consider. The journey through this challenging desert requires careful navigation, considering both the terrain and the individual's needs.

Date :
  1. Date Completed 1996-06-13
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

8618581

DOI: Digital Object Identifier

10.1056/NEJM199605303342203

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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