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A double-blind placebo-controlled trial with loperamide in irritable bowel syndrome.

Author: BernklevT, EfskindP S, VatnM H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the effects of loperamide on irritable bowel syndrome (IBS) symptoms. Previous studies showed that loperamide can relax spasms in the large intestine and improve symptoms of diarrhea. This study aimed to examine the effects of loperamide in a diverse group of people with IBS, acknowledging that IBS symptoms can be caused by different factors affecting bowel movement.
Paper Details　
Original Abstract of the Article :
Loperamide has a relaxing effect on localized and segmental large-bowel spasms. On the basis of previously observed effects on pain and stool habits in patients with diarrhoea, the present trial intended to examine the regulating effect in an unselected cohort of patients with the irritable bowel sy...See full text at original site
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引用元：
https://doi.org/10.3109/00365529609006766

データ提供：米国国立医学図書館（NLM）

Loperamide in Irritable Bowel Syndrome (IBS)

Irritable bowel syndrome (IBS), like a desert wind, can cause unpredictable and uncomfortable digestive disturbances. This study investigates the potential of loperamide, a medication known for its anti-diarrheal effects, in managing IBS. The authors conducted a double-blind, placebo-controlled trial to evaluate the effects of loperamide on IBS symptoms in an unselected cohort of patients. The results of this study explore the role of loperamide in regulating bowel motility, offering insights into its potential as a therapeutic option for IBS.

Understanding the Complexity of IBS

The findings of this study contribute to our understanding of the complex interplay between bowel motility and IBS symptoms. This research is like a compass guiding us through the intricate maze of IBS, helping us to identify potential therapeutic targets.

Navigating IBS with Loperamide

This study offers valuable information for clinicians managing IBS patients, providing insights into the potential benefits of loperamide. It's like a wellspring of knowledge, offering hope for patients seeking relief from their symptoms.

Dr.Camel's Conclusion

This study, like a lone traveler crossing a vast desert, ventures into the complexities of IBS, exploring the potential of loperamide as a therapeutic option.

Date :
  1. Date Completed 1996-10-09
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

8734343

DOI: Digital Object Identifier

10.3109/00365529609006766

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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