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An integrated approach for the evaluation of psychotropic drug in man. I. Studies on amphetamine. Relationship between drug levels and psychophysiological measurements.

Author: De LisioG, GomeniR, GuazelliM, MagginiC, MorselliP L, PlacidiG F, StandenS, TognoniG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

The effects of two different amphetamine formulations were evaluated in healthy volunteers using an integrated approach that included drug plasma levels, central (CNS) and peripheral responses, and performance tests. The study found interesting relationships between the initial rate of entry of amphetamine into the blood stream and both the incidence of side effects and the rise in arterial blood pressure. The methodology used in this study may be valuable for evaluating psychotropic drug effects in humans.
Paper Details　
Original Abstract of the Article :
Following an integrated approach based on the contemporary recording of drug plasma levels, central (CNS) and peripheral responses and performance tests, the effects of two different amphetamine formulations were evaluated in healthy volunteers. Interesting relationships were observed between amphet...See full text at original site
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引用元：
https://doi.org/10.1007/BF00421394

データ提供：米国国立医学図書館（NLM）

Amphetamine: Navigating the Shifting Sands of Psychotropic Drug Effects

The study of psychotropic drugs is a vast and often unpredictable desert, with the effects of these substances varying greatly depending on individual factors. This study delved into the effects of amphetamine, a stimulant drug, using an integrated approach that combined drug plasma levels, central nervous system (CNS) and peripheral responses, and performance tests. The researchers sought to illuminate the complex interplay between drug levels and physiological and psychological responses to amphetamine, mapping the shifting sands of its effects on the human body and mind.

A Complex Landscape: Mapping the Effects of Amphetamine

The study found that the initial rate of amphetamine entry into the bloodstream was correlated with both the incidence of side effects and the rise in arterial blood pressure. The researchers also identified minimal thresholds for CNS and peripheral effects, revealing the delicate balance between therapeutic benefit and potential adverse effects. This is like navigating a desert with shifting sand dunes, where the terrain can change rapidly and unpredictably.

Amphetamine: A Powerful Tool with Potential Risks

Amphetamine, like a powerful desert wind, can have both beneficial and detrimental effects. While it can enhance alertness and improve performance, it can also cause unwanted side effects. This study emphasizes the importance of careful monitoring and dose adjustment to optimize therapeutic benefits and minimize potential risks, just like a camel caravan adapting to the changing conditions of a desert journey.

Dr. Camel's Conclusion

The study of amphetamine serves as a reminder of the complexity of psychotropic drugs and the importance of a comprehensive approach to their evaluation and use. Just like a camel caravan navigating a vast and unforgiving desert, researchers and clinicians must navigate the shifting sands of drug effects to ensure patient safety and optimize therapeutic outcomes.

Date :
  1. Date Completed 1976-10-02
  2. Date Revised 2020-01-08
Further Info :

Pubmed ID

951456

DOI: Digital Object Identifier

10.1007/BF00421394

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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