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[Combination therapy in early rheumatoid arthritis: the COBRA study].

Author: BoersM, VerhoevenA C, van der LindenS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of early rheumatoid arthritis (RA) found that combining sulfasalazine, prednisolone, and methotrexate for the first six months (COBRA scheme) was more effective than sulfasalazine alone over 1.5 years. The combination treatment resulted in less disease activity, less joint damage, and fewer side effects, while costing the same or less. The study recommends more aggressive treatment for early RA with a reassessment of the use of corticosteroids.
Paper Details　
Original Abstract of the Article :
The scheme 'Combination therapy in rheumatoid arthritis' (COBRA) in early rheumatoid arthritis (RA) involves administration of not only sulfasalazine but also prednisolone and methotrexate during the first six months. The trial showed that the COBRA scheme over a period of 1.5 years was superior to ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9555126

データ提供：米国国立医学図書館（NLM）

Combating Rheumatoid Arthritis: A Multifaceted Approach

Rheumatoid arthritis is a chronic inflammatory disease that can significantly impact an individual's quality of life, like a persistent sandstorm that erodes their ability to move freely. This research explores the effectiveness of a combination therapy approach in managing early rheumatoid arthritis, aiming to find a more effective and comprehensive strategy for combating this debilitating condition.

The authors examined the effectiveness of a combination therapy scheme involving sulfasalazine, prednisolone, and methotrexate in patients with early rheumatoid arthritis. They compared this combination therapy with sulfasalazine alone, finding that the combination approach was superior in reducing disease activity, minimizing articular damage, and reducing side effects. This research highlights the potential benefits of a multi-faceted approach to managing rheumatoid arthritis, emphasizing the importance of considering multiple therapeutic strategies to optimize treatment outcomes.

A Multi-Faceted Approach to Rheumatoid Arthritis

This research highlights the potential benefits of a combination therapy approach in managing early rheumatoid arthritis. The findings suggest that combining multiple medications can be more effective in reducing disease activity, minimizing joint damage, and reducing side effects. This approach offers a promising avenue for improving the lives of individuals with rheumatoid arthritis.

Navigating the Desert of Rheumatoid Arthritis

The findings of this study provide valuable insights into the management of rheumatoid arthritis, emphasizing the importance of a comprehensive and multi-faceted approach. This research underscores the need for ongoing research and the development of new therapies to improve the lives of individuals living with this challenging condition.

Dr. Camel's Conclusion

This research highlights the effectiveness of a combination therapy approach in managing early rheumatoid arthritis, suggesting that combining multiple medications can be more effective in reducing disease activity, minimizing joint damage, and reducing side effects. It's a reminder that when facing a complex health challenge, a multi-faceted approach can often lead to more successful outcomes.

Date :
  1. Date Completed 1998-07-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9555126

DOI: Digital Object Identifier

9555126

SNS
PICO Info
in preparation
Languages

Dutch

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