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Combination therapy in rheumatoid arthritis: updated systematic review.

Author: BoersM, TugwellP, VerhoevenA C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A review of research on combination drug treatment for rheumatoid arthritis (RA) found that using a combination of medications, including corticosteroids, in patients with early RA was more effective than using only one medication, and had acceptable side effects. The beneficial effects on joint damage may last, but symptom relief may require ongoing corticosteroid use. For patients with later-stage RA, cyclosporine was effective in improving responses to methotrexate. A combination of methotrexate, sulfasalazine, and hydroxychloroquine was also found to be more effective than individual medications. Further research is needed to confirm these findings, as there are limited studies and small sample sizes for many combinations.
Paper Details　
Original Abstract of the Article :
In a second update of a systematic review, many new developments in the combined drug treatment of rheumatoid arthritis (RA) are highlighted. In early RA patients, step-down bridge therapy that includes corticosteroids leads to much enhanced efficacy at acceptable or low toxicity. The effects on joi...See full text at original site
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引用元：
https://doi.org/10.1093/rheumatology/37.6.612

データ提供：米国国立医学図書館（NLM）

Rheumatoid Arthritis: Exploring Combination Therapies for Effective Treatment

This study explores the use of [combination therapies] for treating [rheumatoid arthritis (RA)]. Imagine a desert where the researchers are testing different combinations of oasis – drugs – to find the most effective way to manage this chronic inflammatory disease. The researchers conducted a systematic review to assess the efficacy of various drug combinations for treating [rheumatoid arthritis (RA)]. Their findings provide valuable insights into the potential benefits and challenges of [combination therapies] for this condition.

Combination Therapies for Rheumatoid Arthritis: A Comprehensive Review

The researchers found that [combination therapies] can be more effective than single drug therapies in treating [rheumatoid arthritis (RA)]. However, the optimal combination and dosage of drugs can vary depending on the individual patient. This research emphasizes the need for personalized medicine approaches to managing [rheumatoid arthritis (RA)] and optimizing treatment strategies.

Living with Rheumatoid Arthritis: Managing Symptoms and Seeking Treatment

If you or someone you know is struggling with [rheumatoid arthritis (RA)], it's essential to consult with a medical professional to discuss appropriate treatment options and manage the condition effectively. This research, like a camel finding a hidden oasis in the desert, offers hope for individuals seeking relief from the pain and limitations of [rheumatoid arthritis (RA)] by exploring the benefits of [combination therapies].

Dr. Camel's Conclusion

This research delves into the complex world of [combination therapies] for [rheumatoid arthritis (RA)]. By providing a comprehensive overview of different drug combinations, the study offers valuable insights for clinicians to develop personalized treatment plans. This research, like a camel traversing a vast and challenging desert, reminds us that the search for effective treatments for chronic diseases is ongoing and requires a collaborative approach to ensure optimal patient outcomes.

Date :
  1. Date Completed 1998-07-29
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

9667614

DOI: Digital Object Identifier

10.1093/rheumatology/37.6.612

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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