Effects of budesonide nasal spray: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Main Research Findings

Budesonide nasal spray has been shown to be effective in treating allergic rhinitis and chronic rhinosinusitis in several studies. 3 found that budesonide nasal spray improved local symptoms and systemic immune function in patients with chronic rhinosinusitis with nasal polyps. 21 showed that budesonide nasal spray effectively reduced nasal mucosal swelling and congestion in patients with rhinitis medicamentosa. 26 demonstrated that budesonide nasal spray reduced nasal resistance and improved head posture in children with asthma and perennial rhinitis. 14 indicated that budesonide nasal spray does not hinder ciliary beat frequency in human nasal mucosa. 27 concluded that budesonide nasal spray is more effective than oral antihistamines for treating seasonal allergic rhinitis. 11 suggested that budesonide nasal spray could be used as a prophylactic treatment for allergic rhinitis. 13 suggested that the therapeutic response to budesonide nasal spray in treating nasal polyps may be influenced by allergy. 16 showed that budesonide nasal spray can suppress IL-5 and eosinophil activation during natural allergen exposure in allergic rhinitis. 8 found that budesonide nasal spray is effective in treating neutrophilic chronic rhinosinusitis with nasal polyps. 25 found that budesonide nasal spray is as effective as methylprednisolone acetate in treating seasonal allergic rhinitis. 5 indicated that moxibustion combined with budesonide nasal spray is effective in treating persistent allergic rhinitis. 15 found that nasal polyps with a positive allergy skin test showed less improvement after treatment with budesonide nasal spray. 2 indicated that budesonide nasal spray is effective in treating seasonal rhinitis and is superior to placebo. 9 suggested that azelastine can enhance the efficacy of budesonide nasal spray in treating allergic rhinitis. 17 demonstrated that exhaling budesonide inhaler through the nose reduces the dose requirement of budesonide nasal spray in patients with asthma and rhinitis. 18 showed that long-term use of budesonide nasal spray does not increase the risk of ocular hypertension or cataracts. 19 found that budesonide nasal spray is effective in treating seasonal allergic rhinitis and is comparable to fluticasone propionate nasal spray. 23 found that budesonide nasal spray is more effective than oral astemizole for treating perennial rhinitis. 12 reported that budesonide nasal spray can rarely cause type IV hypersensitivity reactions. 6 found that a solubilized, low-dose budesonide nasal spray rapidly improves symptoms of allergic rhinitis. 24 found that budesonide nasal spray is more effective than allergen-injection therapy for controlling seasonal allergic rhinoconjunctivitis. 1 showed that budesonide nasal spray is effective in treating grass pollen rhinitis. 10 suggested that budesonide inhalation suspension is effective and safe for treating chronic rhinosinusitis with nasal polyps. 7 suggested that high-dose budesonide nasal spray is potentially effective for treating chronic rhinosinusitis with nasal polyps. 2 indicated that budesonide nasal spray is effective and well-tolerated in treating seasonal rhinitis. 20 indicated that budesonide nasal spray is effective in treating rhinitis medicamentosa. 4 found that a generic budesonide nasal spray is bioequivalent to the branded version.

Benefits and Risks

Benefits Summary

Budesonide nasal spray has been shown to be effective in treating symptoms of allergic rhinitis and chronic rhinosinusitis. 3 The medication reduces nasal mucosal swelling, congestion, and nasal resistance. 21 26 It can also be used as a prophylactic treatment for allergic rhinitis. 11 Generic versions of budesonide nasal spray are bioequivalent to branded versions. 4

Risks Summary

Budesonide nasal spray can rarely cause type IV hypersensitivity reactions. 12 While studies suggest that long-term use does not significantly increase the risk of ocular hypertension or cataracts, caution is still advised. 18 It is essential to consult with a healthcare professional before using budesonide nasal spray during pregnancy or breastfeeding.

Comparison Across Studies

Commonalities

Multiple studies consistently demonstrate the effectiveness of budesonide nasal spray in managing allergic rhinitis and chronic rhinosinusitis.

Differences

The efficacy of budesonide nasal spray can vary depending on factors such as the presence of allergies, the type of chronic rhinosinusitis, and the specific treatment regimen. 13 15 Some studies have explored the potential benefits of combining budesonide nasal spray with other therapies. 5 9 17

Consistency and Inconsistencies in Findings

While numerous studies support the effectiveness of budesonide nasal spray, the extent of its efficacy can vary across studies. Further research is needed to understand the long-term safety and effectiveness of budesonide nasal spray, especially during pregnancy and breastfeeding.

Considerations for Real-World Application

While budesonide nasal spray is effective in managing symptoms of allergic rhinitis and chronic rhinosinusitis, it’s important to remember that it may take several weeks to experience full benefits. 3 It is essential to use budesonide nasal spray according to your healthcare provider’s instructions. If you experience any adverse reactions, consult with your doctor immediately.

Limitations of Current Research

The long-term safety and efficacy of budesonide nasal spray require further investigation. More research is needed to evaluate the use of budesonide nasal spray during pregnancy and breastfeeding.

Future Research Directions

Long-term safety and efficacy studies are needed to establish the long-term effects of budesonide nasal spray. Research exploring the use of budesonide nasal spray during pregnancy and breastfeeding is crucial. Additional studies are required to evaluate the combination of budesonide nasal spray with other therapies for optimal patient outcomes.

Conclusion

Budesonide nasal spray is a valuable treatment option for managing symptoms of allergic rhinitis and chronic rhinosinusitis. 3 It effectively reduces nasal inflammation and congestion. 21 26 While generally safe and well-tolerated, it is essential to use budesonide nasal spray according to your healthcare provider’s instructions. Further research is needed to address specific aspects of its use, such as long-term safety and efficacy, as well as its use during pregnancy and breastfeeding.

Literature analysis of 28 papers
Positive Content
25
Neutral Content
1
Negative Content
2
Article Type
15
0
0
1
28
1.

Budesonide in grass pollen rhinitis.

Author: NormanP S, CreticosP S, TobeyR, ProudD G, Kagey-SobotkaA, MeyersD A, PerssonT

Reduced allergic rhinitis symptoms

Budesonide nasal spray was found to be significantly more effective than placebo in treating seasonal allergic rhinitis. Patients receiving budesonide had a greater reduction in symptoms of sneezing, stuffy nose, and nasal secretion. There was no difference in eye itch or rescue medication use between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Budesonide - a new steroid for intranasal use. A double-blind clinical comparison between budesonide and placebo in patients with seasonal allergic rhinitis.

Author: WarlandA, MøllerP, LindqvistN

Effective for seasonal rhinitis
Mild side effects

Budesonide nasal spray was more effective than placebo in treating seasonal rhinitis in 29 patients. Side effects were mild and infrequent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Pharmacokinetics and Bioequivalence of a Generic and a Branded Budesonide Nasal Spray in Healthy Chinese Subjects.

Author: LiXin, LiYuan, XuBing, ZhangPing, WangYangyang, WangZhenyu, HouShuguang

This study evaluated the pharmacokinetic bioequivalence of a generic budesonide nasal spray and a branded product in healthy Chinese subjects under fasting condition. The test and reference budesonide nasal sprays were PK bioequivalents in healthy Chinese subjects with comparable PK parameters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Fast effectiveness of a solubilized low-dose budesonide nasal spray in allergic rhinitis.

Author: ZieglmayerPetra, SchmutzRené, LemellPatrick, Unger-ManhartNicole, NakowitschSabine, GoesslAndreas, SavliMarkus, ZieglmayerRené, Prieschl-GrassauerEva

Allergic rhinitis relief
Early onset of action

Budesolv 10, a novel aqueous formulation of budesonide, was non-inferior to Rhinocort® Aqua 64 (RA) in treating grass pollen allergic rhinoconjunctivitis. Budesolv 10 showed a significant reduction in nasal and respiratory symptoms starting 90 minutes after application, demonstrating an early onset of efficacy. Budesolv 10 may be an effective acute treatment for allergic rhinitis and AR comorbidities like mild asthma and conjunctivitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Equivalence TrialA clinical trial designed to show that a new treatment is equivalent in efficacy/safety to an existing treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Efficacy of Budesonide Nasal Spray on Neutrophilic Chronic Rhinosinusitis with Nasal Polyps: A Combined Clinical and Experimental Study.

Author: LinLin, LanJing, DaiFei, WeiJinjin, ChenZheng, SunGuangbin

CRSwNP inflammation

Budesonide nasal spray did not improve clinical evaluations or inflammatory markers in patients with neutrophilic chronic rhinosinusitis with nasal polyps. The study suggests that budesonide treatment may not be effective in alleviating the inflammatory condition in this specific type of CRSwNP.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Azelastine enhances the clinical efficacy of glucocorticoid by modulating MKP-1 expression in allergic rhinitis.

Author: LuoXi, MaRenqiang, WuXingmei, XianDesheng, LiJian, MouZhonglin, LiHuabin

Allergic rhinitis control
Anti-inflammatory effect

Azelastine and budesonide, both anti-inflammatory agents, were found to additively enhance the anti-inflammatory effect of budesonide by modulating MKP-1 expression, which may be effective in the treatment of uncontrolled severe allergic rhinitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

[The efficacy and safety of a short course of budesonide inhalation suspension via transnasal nebulization in chronic rhinosinusitis with nasal polyps].

Author: WangChengshuo, LouHongfei, LouWei, ZhangLuo

Improved symptoms
Reduced polyp size
HPA axis suppression

Nebulized budesonide transnasal inhalation rapidly improved nasal symptoms, reduced polyp size, and did not cause obvious HPA axis suppression in patients with chronic rhinosinusitis with nasal polyps.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : Chinese

11.

[To investigate the effect of pretreatment with budesonide spray in patients with allergic rhinitis].

Author: NingXianhui, XingZhimin, WangMin, GaoZhihong

Avoided attacks
Reduced symptoms
None mentioned

Prophylactic administration of budesonide nasal spray two weeks before the onset of the mugwort allergy season was effective in reducing symptoms and even preventing attacks of allergic rhinitis.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

12.

Type IV delayed-type hypersensitivity of the respiratory tract due to budesonide use: report of two cases and a literature review.

Author: PitsiosConstantinos, StefanakiEfthalia C, HelblingArthur

Hypersensitivity Reactions

Nasal and inhaled corticosteroids can cause respiratory type-IV hypersensitivity reactions, as seen in two cases involving budesonide nasal spray and a formoterol/budesonide spray. Patch testing confirmed the reactions to budesonide.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

13.

Nasal polyposis: role of allergy on therapeutic response of eosinophil- and noneosinophil-dominated inflammation.

Author: KirtsreesakulVirat, AtchariyasathianViraporn

Therapeutic improvement

Nonallergic eosinophilic nasal polyps had the best therapeutic response, while allergic noneosinophilic polyps had the worst. Allergic nasal polyps had less therapeutic response than nonallergic polyps within each histopathology.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Influence of preservatives and topical steroids on ciliary beat frequency in vitro.

Author: HofmannThiemo, GugatschgaMarkus, KoidlBernd, WolfGerald

Preservative safe for cilia
Steroid spray can harm cilia

Topical steroid sprays containing benzalkonium chloride can cause a decrease in ciliary beat frequency (CBF) in human nasal mucosa. Potassium sorbate, a preservative, does not have a negative influence on CBF.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Role of allergy in the therapeutic response of nasal polyps.

Author: KirtsreesakulVirat

Improved nasal polyps

This study found that nasal polyps with positive allergen skin tests had less improvement than nasal polyps with negative allergen skin tests after treatment with Budesonide nasal spray. This suggests that allergies may affect the therapeutic response to treatment for nasal polyps.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Mechanism of topical glucocorticoid treatment of hay fever: IL-5 and eosinophil activation during natural allergen exposure are suppressed, but IL-4, IL-6, and IgE antibody production are unaffected.

Author: KitaH, JorgensenR K, ReedC E, DunnetteS L, SwansonM C, BartemesK R, SquillaceD, BlomgrenJ, BachmanK, GleichG J

Allergic rhinitis is a hypersensitivity reaction that is traditionally thought to be mediated by IgE and mast cells. However, recent research suggests that cytokines and eosinophil mediators may also play a role.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Exhaling a budesonide inhaler through the nose results in a significant reduction in dose requirement of budesonide nasal spray in patients having asthma with rhinitis.

Author: ShaikhW A

Asthma treatment
Reduced nasal spray dose
Rhinitis treatment

Budesonide, an inhaled corticosteroid, is used for bronchial asthma and rhinitis. This study investigated whether exhaling budesonide through the nose after inhalation could reduce the dose requirement of budesonide nasal spray in patients with perennial allergic asthma and rhinitis. Results showed that exhaling through the nose significantly improved symptoms and peak nasal inspiratory flow rates, leading to a 40.1% reduction in the dose requirement of budesonide nasal spray.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

A comparison of aqueous suspensions of budesonide nasal spray (128 micrograms and 256 micrograms once daily) and fluticasone propionate nasal spray (200 micrograms once daily) in the treatment of adult patients with seasonal allergic rhinitis.

Author: SternM A, DahlR, NielsenL P, PedersenB, SchreweliusC

Reduced eye symptoms
Reduced nasal symptoms
Adverse events

Budesonide and fluticasone propionate nasal sprays were effective and well-tolerated in treating seasonal allergic rhinitis. Budesonide at 256 micrograms/day was more effective than fluticasone propionate at 200 micrograms/day and budesonide at 128 micrograms/day, especially when patients were exposed to higher pollen levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

The pathophysiology and treatment of rhinitis medicamentosa.

Author: GrafP, HallénH, JutoJ E

Budesonide effective

Budesonide nasal spray was effective in treating rhinitis medicamentosa, allowing patients to discontinue topical vasoconstrictors. Objective variables showed that treatment for at least 6 weeks was necessary. The results suggest that rebound swelling is due to interstitial edema rather than vasodilation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Budesonide in grass pollen rhinitis.

Author: NormanP S, CreticosP S, TobeyR, ProudD G, Kagey-SobotkaA, MeyersD A, PerssonT

Reduced allergic rhinitis symptoms

Budesonide nasal spray was found to be significantly more effective than placebo in treating seasonal allergic rhinitis. Patients receiving budesonide had a greater reduction in symptoms of sneezing, stuffy nose, and nasal secretion. There was no difference in eye itch or rescue medication use between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

A double-blind comparison of nasal budesonide and oral astemizole for the treatment of perennial rhinitis.

Author: BunnagC, JareoncharsriP, WongE C

Improved efficacy
Reduced symptoms
Safe treatment
Mild side effects

Budesonide nasal spray was significantly more effective than oral astemizole in treating symptomatic perennial rhinitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Comparison of the efficacy and side effects of aqueous steroid nasal spray (budesonide) and allergen-injection therapy (Pollinex-R) in the treatment of seasonal allergic rhinoconjunctivitis.

Author: JuniperE F, KlineP A, RamsdaleE H, HargreaveF E

Effective for rhinitis
Systemic reactions

Budesonide aqueous nasal spray was markedly more effective than Pollinex-R in controlling symptoms of seasonal rhinitis. Budesonide was well-tolerated with no clinically important side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Clinical comparison of systemic methylprednisolone acetate versus topical budesonide in patients with seasonal allergic rhinitis.

Author: PichlerW J, KlintT, BlaserM, GrafW, SauterK, WeissS, WitschiK

Allergic rhinitis treatment
Mild side effects

Budesonide nasal spray and methylprednisolone acetate injection were compared for treating seasonal allergic rhinitis. Both treatments significantly improved symptoms, but budesonide was more effective in reducing nasal symptoms, while methylprednisolone was more effective in reducing the need for eyedrops. Both treatments were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Nasal respiratory resistance and head posture: effect of intranasal corticosteroid (Budesonide) in children with asthma and perennial rhinitis.

Author: WenzelA, HenriksenJ, MelsenB

Budesonide efficacy
Nasal obstruction

Budesonide nasal spray reduced nasal obstruction in 18 out of 37 children with asthma and nasal obstruction. A reduced nasal resistance led to a decrease in craniocervical angulation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

A comparative study of dexchlorpheniramine maleate sustained release tablets and budesonide nasal spray in seasonal allergic rhinitis.

Author: MunchE P, SøborgM, NørresletT T, MygindN

Reduces nasal blockage
Treats seasonal allergies
Drowsiness
Eye irritation

Budesonide nasal spray was more effective than dexchlorpheniramine in reducing nasal blockage in patients with seasonal allergic rhinitis. Budesonide had fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Budesonide - a new steroid for intranasal use. A double-blind clinical comparison between budesonide and placebo in patients with seasonal allergic rhinitis.

Author: WarlandA, MøllerP, LindqvistN

Effective for seasonal rhinitis
Mild side effects

Budesonide nasal spray was more effective than placebo in treating seasonal rhinitis in 29 patients. Side effects were mild and infrequent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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