Effective treatment of carpal tunnel syndrome: A Synthesis of Findings from 128 Studies

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Original Abstract of the Article

Major Research Findings

Many studies have shown that there are both surgical and non-surgical treatments for carpal tunnel syndrome. Surgical treatment involves cutting the ligament in the carpal tunnel to relieve pressure on the median nerve. 35 , 22 , 90 , 97 , 19 , 32 , 23 , 66 , 6 , 8 , 74 , 98 , 113 Non-surgical treatment includes the use of wrist splints, steroid injections, and physical therapy. 35 , 22 , 58 , 63 , 84 , 52 , 79 , 126 , 55 , 27 , 7 , 24 , 83 , 50 , 12 , 39 , 5 , 26 , 88 Which treatment is more effective depends on the severity of the patient's symptoms and other factors. 26

Treatment Summary

Many studies have shown that there are both surgical and non-surgical treatments for carpal tunnel syndrome. Surgical treatment involves cutting the ligament in the carpal tunnel to relieve pressure on the median nerve. 35 , 22 , 90 , 97 , 19 , 32 , 23 , 66 , 6 , 8 , 74 , 98 , 113 Non-surgical treatment includes the use of wrist splints, steroid injections, and physical therapy. 35 , 22 , 58 , 63 , 84 , 52 , 79 , 126 , 55 , 27 , 7 , 24 , 83 , 50 , 12 , 39 , 5 , 26 , 88 Which treatment is more effective depends on the severity of the patient's symptoms and other factors. 26

Benefits and Risks

Benefit Summary

Surgical treatment for carpal tunnel syndrome is often effective in improving symptoms, as shown by multiple studies. 22 , 97 , 19 Surgical treatment can be expected to improve the function of the median nerve by releasing pressure in the carpal tunnel. 27 Surgical treatment has risks, such as scarring and infection, but these risks are considered relatively low. 90 Non-surgical treatment has the advantage of being less risky than surgical treatment. 7 , 24 However, the effects of non-surgical treatment may be shorter than those of surgical treatment. 58 Steroid injections for carpal tunnel syndrome have been shown to be effective in the short term, but long-term studies have shown that these effects do not last. 7 The use of wrist splints and exercises such as tendon and nerve gliding exercises may be effective in improving symptoms of carpal tunnel syndrome. 24 , 50 , 39 Acupuncture, TDP irradiation, and Chinese herbal steaming and washing may be effective treatments for early symptoms of carpal tunnel syndrome. 52

Risk Summary

Surgical treatment for carpal tunnel syndrome carries the risk of scarring and infection. 90 Steroid injections for carpal tunnel syndrome have been shown to be effective in the short term, but long-term studies have shown that these effects do not last. 7 Steroid injections also carry the risk of side effects such as osteoporosis and increased blood sugar. 55

Comparison Between Studies

Commonalities in Studies

Many studies have shown that both surgical and non-surgical treatments for carpal tunnel syndrome are effective. 22 , 97 , 35 , 83 , 26 However, the most effective treatment varies depending on the severity of the patient's symptoms and other factors. 26

Differences in Studies

There is variability in research findings when comparing the effectiveness of surgical and non-surgical treatments for carpal tunnel syndrome. 22 , 97 , 35 This variability is thought to be influenced by differences in the patient populations studied, the treatments used, and the study design. 26 There is also variability in research findings on the effectiveness of steroid injections for carpal tunnel syndrome. 58 , 7 This is thought to be influenced by differences in the injection method and the type of steroid used. 55 There are a number of different methods for performing carpal tunnel release surgery. 32 , 23 , 66 , 6 , 8 , 74 , 98 , 113 Studies have been conducted to compare the effectiveness and safety of these methods. 81

Consistency and Contradictions in Findings

Some contradictions have been observed in research comparing the effectiveness of surgical and non-surgical treatments for carpal tunnel syndrome. 22 , 97 , 35 For example, 22 found that surgical treatment was more effective in improving symptoms, while 97 found no significant difference between surgical and non-surgical treatment. 35 found no difference in symptom improvement after one year between surgical treatment and steroid injections. These contradictions are thought to be influenced by differences in the patient populations studied, the treatments used, and the study design. 26 There is also variability in research findings on the effectiveness of steroid injections for carpal tunnel syndrome. 58 , 7 This is thought to be influenced by differences in the injection method and the type of steroid used. 55

Points to Note in Applying Findings to Real Life

When choosing a treatment for carpal tunnel syndrome, it is important to consider the severity of the patient's symptoms and other factors. 26 Surgical treatment may be an option for severe cases or when non-surgical treatment has not been effective. 26 Non-surgical treatment may be appropriate for patients with mild to moderate symptoms. 83 It is essential to consult with your doctor to determine the best treatment for you. 26 , 83 If you are considering surgery, it is essential to get information from your doctor about the risks and complications of surgery. 90 If you are undergoing non-surgical treatment, it is essential to continue using wrist splints and performing exercises such as tendon and nerve gliding exercises. 24 , 50 , 39 If your symptoms of carpal tunnel syndrome do not improve, it is essential to consult with your doctor to discuss revising your treatment plan. 26 , 83

Current Research Limitations

Variability in research findings comparing the effectiveness of surgical and non-surgical treatments for carpal tunnel syndrome is influenced by differences in the patient populations studied, the treatments used, and the study design. 26 There is also variability in research findings on the effectiveness of steroid injections for carpal tunnel syndrome. 58 , 7 This is thought to be influenced by differences in the injection method and the type of steroid used. 55 More research is needed to identify the optimal treatment for carpal tunnel syndrome. 83 , 72

Future Research Directions

Variability in research findings comparing the effectiveness of surgical and non-surgical treatments for carpal tunnel syndrome is influenced by differences in the patient populations studied, the treatments used, and the study design. 26 More research is needed to identify the optimal treatment for carpal tunnel syndrome. 83 , 72 Specifically, research is needed that tracks the long-term effects of steroid injections for carpal tunnel syndrome and compares different surgical methods. 55 , 81

Conclusion

There are both surgical and non-surgical treatments for carpal tunnel syndrome, and the best option depends on the severity of the patient's symptoms and other factors. 26 It is essential to consult with your doctor to determine the best treatment for you. 26 , 83 If you are considering surgery, it is essential to get information from your doctor about the risks and complications of surgery. 90 If your symptoms of carpal tunnel syndrome do not improve, it is essential to consult with your doctor to discuss revising your treatment plan. 26 , 83

Treatment List

Here are the treatment keywords based on the research: * Surgical treatment * Carpal tunnel release * Flexor tenosynovectomy * Non-surgical treatment * Wrist splint * Steroid injection * Physical therapy * Tendon and nerve gliding exercises * Ultrasound therapy * Acupuncture * TDP irradiation * Chinese herbal medicine * Warm compress * Kinesio taping * Pregabalin

Keywords
Benefit Keywords
Relief of symptoms
1
Improved carpal tunnel syndrome symptoms
2
Improved carpal tunnel syndrome outcomes
4
Improved carpal tunnel syndrome outcomes
6
Improved carpal tunnel syndrome outcomes
7
Less postoperative pain
8
Nerve function improvement
Symptom relief
9
Fast recovery
Less pain
Similar to open surgery
10
Improved CTS symptoms
11
Awakening frequency reduction
Pain reduction
Paresthesia reduction
12
Improved carpal tunnel syndrome treatment
13
CTS treatment
15
Improved wrist movement
Reduced need for surgery
Reduced pain
16
Improved return to work and daily living
Relief of CTS symptoms
17
Carpal tunnel syndrome treatment
18
Carpal tunnel syndrome treatment
19
Carpal tunnel syndrome treatment
20
Aid in treatment decisions
21
Improved CTS symptoms
22
Carpal tunnel relief
23
Carpal tunnel treatment
24
Carpal tunnel syndrome treatment
25
Carpal tunnel syndrome treatment
26
Carpal tunnel syndrome treatment
27
CTS treatment
28
Relief of carpal tunnel symptoms
29
Carpal tunnel syndrome treatment
31
Improved carpal tunnel syndrome
32
Carpal tunnel syndrome treatment
33
Reduced pain
Shortened recovery
34
Relieve CTS symptoms
35
CTS treatment
36
Improved neurophysiology
Symptom relief
37
Improved carpal tunnel syndrome treatment
Less painful treatment
Less time-consuming treatment
38
Improved carpal tunnel syndrome treatment
39
Improved CTS symptoms
Improved nerve conduction
40
Reduced scar pain
41
Improved carpal tunnel syndrome treatment
42
Improved carpal tunnel syndrome
43
Carpal tunnel syndrome treatment
44
Earlier return to work
45
Improved carpal tunnel syndrome treatment
46
CTS treatment
47
Carpal tunnel syndrome symptom relief
48
Improved carpal tunnel syndrome treatment
49
Improved functionality
Improved symptoms
50
Carpal tunnel syndrome treatment
51
Carpal tunnel syndrome treatment
52
Carpal tunnel syndrome treatment
53
Acupuncture effective
Tuina manipulation effective
54
CTS treatment
55
Reduced pain
Short-term improvement
56
Improved CTS
Reduced pain
57
Carpal tunnel syndrome treatment
58
CTS treatment
59
CTS treatment
60
Symptom Improvement
Ulnar Nerve Decompression
61
Carpal tunnel syndrome treatment
62
CTS treatment
63
Treatment of carpal tunnel syndrome
64
Improved CTS symptoms
65
Improved early satisfaction
Reduced time to return to work
66
Improved CTS symptoms
67
Simple decompression efficacy
Subjective discomfort reduction
Transposition efficacy
Ulnar neuropathy treatment
68
Treatment of CTS
69
Improved sensory relearning
70
Carpal tunnel syndrome treatment
71
CTS recovery
72
Carpal tunnel syndrome relief
73
CTS treatment
74
CTS treatment
75
CTS treatment
76
CTS treatment
78
CTS treatment
79
Carpal tunnel syndrome treatment
80
Carpal tunnel treatment
81
Carpal tunnel syndrome treatment
82
CTS treatment
83
CTS treatment
84
Carpal tunnel syndrome treatment
85
CTS treatment
86
CTS treatment
87
Nerve function increase
Symptom reduction
88
LLLT for CTS
89
Simultaneous surgery
90
CTS treatment
91
CTS treatment
92
CTS treatment
93
Carpal tunnel syndrome treatment
Platelet-rich plasma
94
CTS pain reduction
Median nerve size reduction
95
Carpal tunnel syndrome treatment
Palmitoylethanolamide
96
CTS treatment
Conservative interventions
Surgical interventions
97
Faster return to activities
Improved early strength recovery
Reduced adverse events
Reduced operative time
98
CTS treatment
PRP
99
CTR
Carpal tunnel syndrome treatment
Local corticosteroid injection
100
Improved motor function
Improved symptoms
Nerve repair
101
Nerve conduction improvement
Pain reduction
102
CTS treatment
103
Faster return to work
Improved daily life functions
Increased satisfaction
Reduced scar complications
104
Symptom improvement
105
CTS treatment
106
BQ improvement
CTS treatment
DN4 improvement
HGS improvement
VAS-pain improvement
107
CTS treatment
108
Improved BLQ scores
Improved paresthesia
Reduced pain
109
Improved function
Symptom relief
110
CTS treatment
111
CTR effectiveness
112
CTS treatment
113
Carpal tunnel syndrome treatment
114
Effective treatment
Short recovery time
115
CTS treatment
Improved function
Reduced pain
116
Improved functional status
Improved muscle strength
Improved pain
Improved range of motion
117
Improved CTS symptoms
Improved hand function
118
Improved CTS symptoms
Improved hand function
Improved pain
119
CTS treatment
120
CTS treatment
121
Improved treatment decisions
122
CTS treatment
123
CTS treatment
124
CTS treatment
125
CTS symptom relief
Improved function
126
CTS symptom reduction
Quality of life improvement
127
Improved grip strength
Improved pinch strength
Improved two-point discrimination
Reduced Phalen's manoeuvre symptoms
128
Risk Keywords
Complications of endoscopic carpal tunnel decompression
3
Complications of endoscopic carpal tunnel release
6
Local complications
8
Nerve injury
Tendon laceration
10
Placebo
NSAID-SR
diuretic ineffective
11
Negative effect on nerve conduction
12
No universally accepted therapy
20
Not useful for diagnosis or prognosis
21
No strong evidence
23
No significant difference in outcomes
30
Insufficient evidence
32
Limited objective evidence
33
No difference
34
Reduced grip strength
37
Carpal tunnel syndrome
38
Carpal tunnel syndrome
39
None mentioned
40
Carpal tunnel syndrome
41
Carpal tunnel syndrome
42
Side effects of steroids
43
Carpal tunnel syndrome
46
Surgical complications
48
Carpal tunnel syndrome
49
Surgical complications
57
Wound Infections
61
Limited evidence of effectiveness
67
Insufficient evidence
Wound infection risk
68
Median nerve injury
Ulnar artery injury
71
Iatrogenic symptoms
72
Postoperative nerve injury
78
ECTR complications
81
Carpal tunnel syndrome surgery
82
Hematoma
Ulnar neuropathy
Wound infections
88
CRPS risk
90
Limited evidence
94
Increased transient nerve injury
104
Carpal tunnel syndrome
107
No additional benefit
110
Unpredictable outcomes
113
Compartment syndrome
Minor complications
115
Poor quality reviews
122
Literature analysis of 128 papers
Positive Content
115
Neutral Content
13
Negative Content
0
Article Type
79
24
43
38
127
1.

Internal neurolysis fails to improve the results of primary carpal tunnel decompression.

Author: MackinnonS E, McCabeS, MurrayJ F, SzalaiJ P, KellyL, NovakC, KinB, BurkeG M

Relief of symptoms

A study comparing two surgical procedures for carpal tunnel syndrome found that both decompression of the transverse carpal ligament and decompression plus internal neurolysis effectively relieved symptoms, but adding neurolysis did not significantly improve outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Internal neurolysis or ligament division only in carpal tunnel syndrome. II. A 3 year follow-up with an evaluation of various neurophysiological parameters for diagnosis.

Author: HolmgrenH, RabowL

Improved carpal tunnel syndrome symptoms

A study of 48 patients with carpal tunnel syndrome found that both internal neurolysis and simple division of the carpal ligament were equally effective in treating the condition.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[Complications after endoscopic carpal tunnel decompression].

Author: HerrenD B, SimmenB R

Complications of endoscopic carpal tunnel decompression

A study of 18 patients who underwent endoscopic decompression for carpal tunnel syndrome found that while most patients had good outcomes, four major complications requiring revision surgery occurred. Two patients still experience residual problems. Due to these complications, the authors stopped using the endoscopic technique and returned to traditional open carpal tunnel decompression surgery.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

4.

Palpatory diagnosis and manipulative management of carpal tunnel syndrome.

Author: SucherB M

Improved carpal tunnel syndrome outcomes

In a study of 20 people with carpal tunnel syndrome, all affected wrists showed significant restriction of movement compared to normal wrists. 16 participants received osteopathic manipulative treatment, including a new technique called the "opponens roll". In those treated, the restriction in movement decreased, often before symptoms improved. Nerve function also improved over time. This study suggests that palpatory diagnosis can help assess the severity of carpal tunnel syndrome and predict outcomes, and that the new manipulative technique may be effective for treating mild to moderate cases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Using pyridoxine to treat carpal tunnel syndrome. Randomized control trial.

Author: SpoonerG R, DesaiH B, AngelJ F, ReederB A, DonatJ R

A study of 32 patients with carpal tunnel syndrome found no benefit from using pyridoxine (vitamin B6) compared to a placebo. There were no differences in electrophysiological or clinical signs, or in symptom severity. This suggests that pyridoxine is not an effective treatment for carpal tunnel syndrome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Carpal tunnel release. A prospective, randomized assessment of open and endoscopic methods.

Author: BrownR A, GelbermanR H, SeilerJ G, AbrahamssonS O, WeilandA J, UrbaniakJ R, SchoenfeldD A, FurcoloD

Improved carpal tunnel syndrome outcomes
Complications of endoscopic carpal tunnel release

A study of 169 hands with carpal tunnel syndrome compared open and endoscopic carpal tunnel release. Both methods were effective in relieving pain and numbness, with similar outcomes for pain relief, sensory function, and motor strength. Patients who had endoscopic surgery were more satisfied with the procedure and had a shorter recovery time, but had a higher rate of complications (4 out of 78 hands). Open surgery resulted in more scar tenderness. The study concluded that both methods are effective, but endoscopic surgery may offer advantages in terms of patient satisfaction and recovery time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Local steroid treatment in idiopathic carpal tunnel syndrome: short- and long-term efficacy.

Author: GirlandaP, DattolaR, VenutoC, MangiapaneR, NicolosiC, MessinaC

Improved carpal tunnel syndrome outcomes

In a study of 32 people with carpal tunnel syndrome (CTS), those who received local steroid injections showed significant improvement compared to those who received saline. However, the improvement was temporary, and most people experienced a worsening of symptoms within six months. After two years, only 8% of those who received steroids continued to show improvement. The duration of improvement appeared to be related to a specific nerve conduction measurement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

[Surgical treatment of carpal tunnel syndrome: endoscopic or classical (open)? A prospective randomized trial].

Author: HoefnagelsW A, van KleefJ G, MastenbroekG G, de BlokJ A, BreukelmanA J, de KromM C

Less postoperative pain
Local complications

Endoscopic carpal tunnel release is as effective as open release but causes less post-operative pain. However, endoscopic release has a higher risk of complications and higher costs, making open release the preferred treatment for carpal tunnel syndrome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Dutch

9.

Ultrasound treatment for treating the carpal tunnel syndrome: randomised "sham" controlled trial.

Author: EbenbichlerG R, ReschK L, NicolakisP, WiesingerG F, UhlF, GhanemA H, FialkaV

Nerve function improvement
Symptom relief

Ultrasound treatment showed significant short-term and medium-term benefits in patients with mild to moderate idiopathic carpal tunnel syndrome compared to sham treatment. Improvements were observed in both subjective symptoms and electroneurographic measures.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Endoscopic treatment of carpal tunnel syndrome: a critical review.

Author: JimenezD F, GibbsS R, ClapperA T

Fast recovery
Less pain
Similar to open surgery
Nerve injury
Tendon laceration

Endoscopic carpal tunnel release surgery offers comparable success and complication rates to standard open procedures, but with less pain and faster return to work.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

11.

Oral drug of choice in carpal tunnel syndrome.

Author: ChangM H, ChiangH T, LeeS S, GerL P, LoY K

Improved CTS symptoms
Placebo
NSAID-SR
diuretic ineffective

For patients with mild to moderate carpal tunnel syndrome opting for conservative treatment, corticosteroids were more effective than diuretics, NSAIDs, or placebo in reducing symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Ultrasound therapy effect in carpal tunnel syndrome.

Author: OztasO, TuranB, BoraI, KarakayaM K

Awakening frequency reduction
Pain reduction
Paresthesia reduction
Negative effect on nerve conduction

Ultrasound therapy, even with placebo, provided symptomatic relief for carpal tunnel syndrome. However, both active treatments resulted in slightly decreased motor nerve conduction velocity and increased distal latency, suggesting a potential negative effect on nerve conduction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Subjective swelling: a new sign for carpal tunnel syndrome.

Author: BurkeD T, BurkeM A, BellR, StewartG W, MehdiR S, KimH J

This study of 186 patients with suspected carpal tunnel syndrome found that subjective hand swelling, while not a strong predictor of diagnosis, was significantly associated with a poor response to splinting. Patients with swelling were less likely to experience pain relief from splinting, even though those with positive electrodiagnostic findings were more likely to experience relief. This suggests that hand swelling may be a useful indicator for predicting treatment outcomes in carpal tunnel syndrome.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Local corticosteroid injection for carpal tunnel syndrome.

Author: MarshallS, TardifG, AshworthN

CTS treatment

Carpal tunnel syndrome (CTS) is a condition caused by pressure on a nerve in the wrist. While it can be treated with surgery or non-surgical methods, the effectiveness and duration of benefit from steroid injections are not yet fully understood, as most studies have been observational and not controlled. This study will investigate the effectiveness of steroid injections for CTS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

An investigation to compare the effectiveness of carpal bone mobilisation and neurodynamic mobilisation as methods of treatment for carpal tunnel syndrome.

Author: Tal-AkabiA, RushtonA

Improved wrist movement
Reduced need for surgery
Reduced pain

This study compared two manual therapy techniques for treating carpal tunnel syndrome (CTS): median nerve mobilization and carpal bone mobilization. Both treatments appeared to be more effective than no treatment, particularly in terms of reduced nerve tension and fewer patients needing surgery. However, statistically significant differences were only found in pain relief. No significant difference in effectiveness was found between the two types of mobilization.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Systematic review of randomized clinical trials of surgical treatment for carpal tunnel syndrome.

Author: GerritsenA A, UitdehaagB M, van GeldereD, ScholtenR J, de VetH C, BouterL M

Improved return to work and daily living
Relief of CTS symptoms

This review compares the effectiveness of different surgical procedures for carpal tunnel syndrome (CTS), looking at how well they relieve symptoms and help people return to work or daily activities. While several surgical options are available, there is no clear agreement on which is best.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Splinting or surgery for carpal tunnel syndrome? Design of a randomized controlled trial [ISRCTN18853827].

Author: GerritsenA A, ScholtenR J, AssendelftW J, KuiperH, de VetH C, BouterL M

Carpal tunnel syndrome treatment

Carpal tunnel syndrome (CTS) is a common condition treated with either surgery or non-surgical approaches. However, there is no agreement on the best treatment for CTS. This study will compare the short-term and long-term effectiveness of surgery and splinting for CTS in a randomized, controlled trial. The study will address methodological limitations of previous studies on CTS treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

The role of flexor tenosynovectomy in the operative treatment of carpal tunnel syndrome.

Author: ShumCharlotte, ParisienMay, StrauchRobert J, RosenwasserMelvin P

Carpal tunnel syndrome treatment

This study investigated the effectiveness of removing the lining of the tendons in the wrist (flexor tenosynovectomy) in addition to the standard surgery for carpal tunnel syndrome (CTS). The study also examined the tissue under a microscope to see if any changes in the tissue were linked to specific symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Surgical versus non-surgical treatment for carpal tunnel syndrome.

Author: VerdugoR J, SalinasR S, CastilloJ, CeaJ G

Carpal tunnel syndrome treatment
No universally accepted therapy

Carpal tunnel syndrome (CTS) is a common condition that occurs when a nerve in the wrist is compressed. Symptoms include tingling, numbness, and pain in the hand, which can spread to the forearm or shoulder. Weakness and muscle wasting in the thumb area may also occur. There is no one best treatment for CTS. Surgery is often preferred for people with severe symptoms, while mild cases may not require treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

A systematic review of the utility of electrodiagnostic testing in carpal tunnel syndrome.

Author: JordanRachel, CarterTim, CumminsCarole

Aid in treatment decisions
Not useful for diagnosis or prognosis

This review evaluated the use of electrodiagnostic tests for diagnosing and treating carpal tunnel syndrome (CTS). While electrodiagnosis was found to be unhelpful for diagnosis in patients with clear CTS symptoms, it may be useful when the diagnosis is uncertain. Regarding treatment, studies did not show any difference in surgical outcomes between patients with positive and negative electrodiagnostic test results. Therefore, electrodiagnosis is not recommended as a predictor of surgical success in patients with clear CTS symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Splinting vs surgery in the treatment of carpal tunnel syndrome: a randomized controlled trial.

Author: GerritsenAnnette A M, de VetHenrica C W, ScholtenRob J P M, BertelsmannFrits W, de KromMarc C T F M, BouterLex M

Improved CTS symptoms

Open carpal tunnel release surgery resulted in better outcomes than treatment with wrist splinting for patients with carpal tunnel syndrome (CTS).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Surgical treatment options for carpal tunnel syndrome.

Author: ScholtenR J P M, GerritsenA A M, UitdehaagB M J, van GeldereD, de VetH C W, BouterL M

Carpal tunnel relief
No strong evidence

There is no strong evidence to support replacing standard open carpal tunnel release with other surgical procedures for treating carpal tunnel syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome.

Author: O'ConnorD, MarshallS, Massy-WestroppN

Carpal tunnel treatment

Current evidence shows significant short-term benefit from oral steroids, splinting, ultrasound, yoga and carpal bone mobilisation for carpal tunnel syndrome. Other non-surgical treatments do not produce significant benefit.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Surgical versus non-surgical treatment for carpal tunnel syndrome.

Author: VerdugoR J, SalinasR S, CastilloJ, CeaJ G

Carpal tunnel syndrome treatment

Carpal tunnel syndrome occurs when a nerve in the wrist is compressed. Symptoms include tingling, numbness, and pain in the hand that can spread to the arm. Surgery is the preferred treatment for severe symptoms, while mild cases often don’t require treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Neurophysiological recovery after open carpal tunnel decompression: comparison of simple decompression and decompression with epineurotomy.

Author: BorischN, HaussmannP

Carpal tunnel syndrome treatment

In a study of 273 people with carpal tunnel syndrome, those who had a standard surgery to release the nerve (decompression) with an additional procedure to cut the outer covering of the nerve (epineurotomy) did not experience significantly better outcomes compared to those who had only the standard surgery. Neither approach led to significantly better results for symptoms or nerve function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Intracarpal steroid injection is safe and effective for short-term management of carpal tunnel syndrome.

Author: ArmstrongTimothy, DevorWilliam, BorschelLaura, ContrerasRichard

CTS treatment

This study found that steroid injections for carpal tunnel syndrome (CTS) that didn't respond to other treatments were effective for providing temporary relief. 70% of patients who received steroids were satisfied or very satisfied with their results, compared to 34% of those receiving a placebo. Steroids also improved nerve function. However, most patients eventually needed surgery for long-term symptom control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

A prospective study to assess the outcome of steroid injections and wrist splinting for the treatment of carpal tunnel syndrome.

Author: GrahamRoger G, HudsonDonald A, SolomonsMichael, SingerMartin

Relief of carpal tunnel symptoms

In a study of 73 people with carpal tunnel syndrome, combining steroid injections with wrist splinting relieved symptoms for most people, but only 10% remained symptom-free after a year. Those who had symptoms for less than 3 months and did not have significant numbness were more likely to have long-term relief. The study suggests that people with mild to moderate carpal tunnel syndrome could initially try a single steroid injection or wear a wrist splint for 3 weeks to see if they respond well to conservative treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

30.

Long-term outcome of carpal tunnel syndrome after conservative treatment.

Author: HuiA C F, WongS M, TangA, MokV, HungL K, WongK S

No significant difference in outcomes

This study followed 60 people with carpal tunnel syndrome (CTS) for 80 weeks after they received either a single injection of steroid or a 10-day course of steroids. After a year, there was no significant difference in symptoms or the number of people who needed surgery between the two groups. Only a small percentage (11.4%) of those who did not have surgery remained symptom-free.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

Long-term effectiveness of steroid injections and splinting in mild and moderate carpal tunnel syndrome.

Author: SevimS, DoguO, CamdevirenH, KaleagasiH, AralM, ArslanE, MilcanA

Carpal tunnel syndrome treatment

This study investigated the long-term effectiveness of non-surgical treatments for carpal tunnel syndrome (CTS). The study compared the effects of wearing a wrist splint nightly, steroid injections near the wrist, and steroid injections further away from the wrist in 120 people with CTS. After a year, wearing a splint almost every night improved symptoms and nerve function, but steroid injections were not effective.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Surgical treatment options for carpal tunnel syndrome.

Author: ScholtenR J P M, GerritsenA A M, UitdehaagB M J, van GeldereD, de VetH C W, BouterL M

Improved carpal tunnel syndrome
Insufficient evidence

The review found no strong evidence to suggest that any alternative surgical procedure for carpal tunnel syndrome is superior to standard open carpal tunnel release in terms of symptom relief, return to work, or occurrence of side effects. More research is needed to compare the effectiveness of different surgical techniques.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Randomized clinical trial of surgery versus conservative therapy for carpal tunnel syndrome [ISRCTN84286481].

Author: MartinBrook I, LevensonLinda M, HollingworthWilliam, KliotMichel, HeagertyPatrick J, TurnerJudith A, JarvikJeffrey G

Carpal tunnel syndrome treatment
Limited objective evidence

While non-surgical treatments are standard for mild to moderate carpal tunnel syndrome, there's limited evidence to support these options. Researchers are exploring whether wrist MRI scans can predict which patients will benefit from specific treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

34.

[Comparison of endoscopic versus open surgical treatment of carpal tunnel syndrome].

Author: ZhaoHong, ZhaoYu, TianYe, YangBo, QiuGui-Xing

Reduced pain
Shortened recovery
No difference

Endoscopic carpal tunnel release (CTR) was as effective as open CTR in treating idiopathic carpal tunnel syndrome (CTS), with significantly reduced operation time, hospitalization time, and recovery time.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

35.

Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one-year, prospective, randomized, open, controlled clinical trial.

Author: Ly-PenDomingo, AndréuJosé-Luis, de BlasGema, Sánchez-OlasoAlberto, MillánIsabel

Relieve CTS symptoms

Local steroid injection is more effective than surgical decompression for the symptomatic relief of carpal tunnel syndrome (CTS) in the short term and as effective as surgical decompression at 1 year.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Determination of sensitive electrophysiologic parameters at follow-up of different steroid treatments of carpal tunnel syndrome.

Author: AygülRecep, UlviHizir, KarataySaliha, DenizOrhan, VarogluAsuman Orhan

CTS treatment

This study compares steroid injections, iontophoresis, and phonophoresis for treating carpal tunnel syndrome (CTS). Steroid injections were most effective, showing significant improvement in nerve function compared to the other treatments. The most sensitive nerve tests for measuring treatment success were those measuring the difference in nerve conduction speed between specific fingers.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

A randomized controlled trial of surgery vs steroid injection for carpal tunnel syndrome.

Author: HuiA C F, WongS, LeungC H, TongP, MokV, PoonD, Li-TsangC W, WongL K, BoetR

Improved neurophysiology
Symptom relief
Reduced grip strength

Open carpal tunnel release resulted in better symptomatic and neurophysiologic outcome compared to steroid injection in patients with idiopathic carpal tunnel syndrome over a 20-week period.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

38.

A novel approach of local corticosteroid injection for the treatment of carpal tunnel syndrome.

Author: HabibGeorge S, BadarnySamih, RawashdehHanna

Improved carpal tunnel syndrome treatment
Less painful treatment
Less time-consuming treatment
Carpal tunnel syndrome

This study compared a new approach to the traditional method of injecting corticosteroids into the wrist for treating carpal tunnel syndrome. Both methods had similar effectiveness in relieving symptoms over time, but the new method was significantly faster and not significantly more painful.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Comparison of three conservative treatment protocols in carpal tunnel syndrome.

Author: BaysalO, AltayZ, OzcanC, ErtemK, YologluS, KayhanA

Improved carpal tunnel syndrome treatment
Carpal tunnel syndrome

This study compared the effectiveness of three different non-surgical treatments for carpal tunnel syndrome (CTS): 1) exercises and splinting, 2) ultrasound and splinting, and 3) ultrasound, splinting, and exercises. All three combinations showed improvement, but patients who received splinting, exercises, and ultrasound reported the most significant long-term relief.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

40.

Efficacy of splinting and oral steroids in the treatment of carpal tunnel syndrome: a prospective randomized clinical and electrophysiological study.

Author: MishraSanjay, PrabhakarSudesh, LalVivek, ModiManish, DasChandi P, KhuranaDheeraj

Improved CTS symptoms
Improved nerve conduction
None mentioned

Splinting and oral steroids were both effective in the management of carpal tunnel syndrome (CTS), with significant improvement in symptom severity score, functional status score, and median nerve sensory and motor distal latency and conduction velocity. The steroid group showed a greater improvement in functional status score than the splint group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Standard open decompression in carpal tunnel syndrome compared with a modified open technique preserving the superficial skin nerves: a prospective randomized study.

Author: SiegmethAlexander W, Hopkinson-WoolleyJames A

Reduced scar pain
Carpal tunnel syndrome

Open carpal tunnel decompression is a common surgery, but 19-61% of patients experience scar discomfort after surgery. This study examines whether preserving small nerve branches that cross the incision site reduces the occurrence and severity of post-surgical scar pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

A comparison of the lidocaine patch 5% vs naproxen 500 mg twice daily for the relief of pain associated with carpal tunnel syndrome: a 6-week, randomized, parallel-group study.

Author: NalamachuSrinivas, CrockettR S, GammaitoniArnold R, GouldErrol M

Improved carpal tunnel syndrome treatment
Carpal tunnel syndrome

This study compares the safety and effectiveness of a lidocaine patch (5%) and naproxen (500 mg twice daily) in treating nerve pain associated with carpal tunnel syndrome (CTS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

A systematic review of conservative treatment of carpal tunnel syndrome.

Author: PiazziniD B, AprileI, FerraraP E, BertoliniC, TonaliP, MaggiL, RabiniA, PiantelliS, PaduaL

Improved carpal tunnel syndrome
Side effects of steroids

Local and oral steroids are effective in the treatment of carpal tunnel syndrome. Splints are also effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Prospective comparison of endoscopic and open surgical methods for carpal tunnel syndrome.

Author: TianYe, ZhaoHong, WangTing

Carpal tunnel syndrome treatment

Endoscopic carpal tunnel release was found to be a reliable and safe treatment for idiopathic carpal tunnel syndrome, showing similar postoperative improvements in symptoms and electromyography results compared to open carpal tunnel release. However, endoscopic release had the advantages of less scar tenderness, shorter operation time, shorter hospital stay, and earlier return to work.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

Surgical treatment options for carpal tunnel syndrome.

Author: ScholtenR J P M, Mink van der MolenA, UitdehaagB M J, BouterL M, de VetH C W

Earlier return to work

This review found that there is no strong evidence supporting the need for replacement of standard open carpal tunnel release by existing alternative surgical procedures for the treatment of carpal tunnel syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Comparison of a targeted and general massage protocol on strength, function, and symptoms associated with carpal tunnel syndrome: a randomized pilot study.

Author: MoraskaAlbert, ChandlerClint, Edmiston-SchaetzelAmanda, FranklinGaye, CalendaElaine L, EneboBrian

Improved carpal tunnel syndrome treatment
Carpal tunnel syndrome

Carpal tunnel syndrome (CTS) is a common and costly problem. This study explores the effectiveness of two different massage therapy approaches for treating CTS, evaluating their impact on strength, function, and symptoms.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

47.

Neural gliding techniques for the treatment of carpal tunnel syndrome: a systematic review.

Author: Medina McKeonJennifer M, YancosekKathleen E

CTS treatment

The efficacy of neural gliding for carpal tunnel syndrome is not clear. More research is needed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Surgical versus non-surgical treatment for carpal tunnel syndrome.

Author: VerdugoRenato J, SalinasRodrigo A, CastilloJosé L, CeaJosé G

Carpal tunnel syndrome symptom relief
Surgical complications

This review assessed the efficacy of surgical versus non-surgical treatment for carpal tunnel syndrome. Four randomized controlled trials were included, with a total of 317 participants. Pooled analysis showed that surgery significantly improved symptoms compared to splinting at 3, 6, and 12 months follow-up. Surgery was also associated with a lower risk of requiring future surgery. However, complications were more common with surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Effects of perineural steroid injections on median nerve conduction during the carpal tunnel release.

Author: StepićNenad, NovakovićMarjan, MartićVesna, PerićDusan

Improved carpal tunnel syndrome treatment
Carpal tunnel syndrome

Carpal tunnel syndrome (CTS) is a condition where the median nerve in the wrist is compressed, leading to numbness, tingling, and pain. The goal of treatment is to restore normal nerve function. This study examines whether applying betamethasone directly to the median nerve during surgery to release pressure on the nerve can help speed up recovery of nerve conduction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

Evaluation of the clinical efficacy of conservative treatment in the management of carpal tunnel syndrome.

Author: BardakAyşe N, AlpMehmet, ErhanBelgin, PakerNurdan, KayaBetül, OnalAyşe E

Improved functionality
Improved symptoms

Standard conservative treatment (SCT) was an effective treatment to improve symptoms and functional status in intermediate stage of carpal tunnel syndrome (CTS). Tendon and nerve gliding exercises alone were inferior to either SCT alone or SCT in combination with gliding exercises.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

Surgery versus non-surgical therapy for carpal tunnel syndrome: a randomised parallel-group trial.

Author: JarvikJeffrey G, ComstockBryan A, KliotMichel, TurnerJudith A, ChanLeighton, HeagertyPatrick J, HollingworthWilliam, KerriganCarolyn L, DeyoRichard A

Carpal tunnel syndrome treatment

A previous study found surgery to be more effective than splinting for carpal tunnel syndrome. This study compares surgery to a multi-modal approach involving non-surgical treatments for carpal tunnel syndrome in patients without nerve damage. The researchers expect that surgery will lead to better function and symptom relief.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.

Language : English

52.

[Observation on therapeutic effects of acupuncture combined with TDP irradiation and chinese herbal steaming and washing therapy for treatment of carpal tunnel syndrome in early stage].

Author: ZhangCui-yan, WangYan-xiang

Carpal tunnel syndrome treatment

Acupuncture combined with TDP irradiation and Chinese herbal steaming and washing therapy both have significant therapeutic effects for the treatment of carpal tunnel syndrome in the early stage.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

53.

Diagnosis, treatment and follow-up of the carpal tunnel syndrome: a review.

Author: AlfonsoCalogero, JannStefano, MassaRoberto, TorreggianiAldo

Carpal tunnel syndrome treatment

Carpal tunnel syndrome is a common nerve condition that can significantly benefit from proper diagnosis, treatment, and follow-up, leading to improved health, social well-being, and economic outcomes. This review summarizes the appropriate steps for diagnosing, treating, and monitoring carpal tunnel syndrome, including the level of evidence and strength of recommendations whenever possible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Warm-needling plus Tuina relaxing for the treatment of carpal tunnel syndrome.

Author: CaiDe-Feng

Acupuncture effective
Tuina manipulation effective

The study found that acupuncture plus Tuina manipulation is a simple therapy for carpal tunnel syndrome with a cure rate of 81.7% compared to 47.4% in the control group.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

Local steroid injection for moderately severe idiopathic carpal tunnel syndrome: protocol of a randomized double-blind placebo-controlled trial (NCT 00806871).

Author: FlondellMagnus, HoferManfred, BjörkJonas, AtroshiIsam

CTS treatment

Steroid injections are commonly used for carpal tunnel syndrome (CTS), but their effectiveness beyond a month hasn't been proven in controlled studies. This study examines the effectiveness of steroid injections for CTS in patients with severe symptoms who are considering surgery but haven't had a steroid injection before.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Carpal tunnel syndrome. Part I: effectiveness of nonsurgical treatments--a systematic review.

Author: HuisstedeBionka M, HoogvlietPeter, RandsdorpManon S, GlerumSuzanne, van MiddelkoopMarienke, KoesBart W

Reduced pain
Short-term improvement

Several nonsurgical interventions, including oral steroids, steroid injections, ultrasound, electromagnetic field therapy, nocturnal splinting, and ergonomic keyboards, showed effectiveness in treating carpal tunnel syndrome (CTS) in the short-term. However, evidence for midterm and long-term effectiveness is sparse.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Carpal tunnel syndrome. Part II: effectiveness of surgical treatments--a systematic review.

Author: HuisstedeBionka M, RandsdorpManon S, CoertJ Henk, GlerumSuzanne, van MiddelkoopMarienke, KoesBart W

Improved CTS
Reduced pain
Surgical complications

Surgical treatment was more effective than splinting or anti-inflammatory drugs plus hand therapy for carpal tunnel syndrome (CTS) in the midterm and long-term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Randomised controlled trial of local corticosteroid injections for carpal tunnel syndrome in general practice.

Author: Peters-VeluthamaningalCyriac, WintersJan C, GroenierKlaas H, Meyboom-de JongBetty

Carpal tunnel syndrome treatment

Carpal tunnel syndrome is a common condition caused by compression of a nerve in the wrist, causing pain, tingling, and numbness. While it is often treated in primary care, the effectiveness of steroid injections for carpal tunnel syndrome administered by general practitioners has not been studied. This study aims to determine if these injections are effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

59.

A randomized clinical trial of acupuncture versus oral steroids for carpal tunnel syndrome: a long-term follow-up.

Author: YangChun-Pai, WangNai-Hwei, LiTsai-Chung, HsiehChing-Liang, ChangHen-Hong, HwangKai-Lin, KoWang-Sheng, ChangMing-Hong

CTS treatment

This study compared acupuncture and steroid treatments for carpal tunnel syndrome (CTS) over a year. 77 patients with mild-to-moderate CTS were randomly assigned to either acupuncture or steroid treatment. At 7 and 13 months, the acupuncture group showed significantly more improvement in symptoms and nerve function compared to the steroid group. For example, at month 13, 81.6% of the acupuncture group experienced good improvement, compared to 48.7% in the steroid group. The study also found a strong correlation between symptom improvement and improved nerve function in the acupuncture group.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

The effectiveness of triamcinolone acetonide vs. procaine hydrochloride injection in the management of carpal tunnel syndrome: a double-blind randomized clinical trial.

Author: KaradaşOmer, TokFatih, UlaşUmit Hidir, OdabaşiZeki

CTS treatment

This study investigates the effectiveness of triamcinolone acetonide injections for carpal tunnel syndrome (CTS), as well as the effectiveness of procaine hydrochloride (a local anesthetic) in treating CTS. The study also compares the efficacy of these two treatments for CTS.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

61.

Treatment for ulnar neuropathy at the elbow.

Author: CaliandroPietro, La TorreGiuseppe, PaduaRoberto, GianniniFabio, PaduaLuca

Symptom Improvement
Ulnar Nerve Decompression
Wound Infections

Simple decompression and transposition of the ulnar nerve were equally effective in treating ulnar neuropathy at the elbow, with higher wound infection rates in the transposition group. Avoiding prolonged movements or positions was effective in improving subjective discomfort in mild cases.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

Is surgical intervention more effective than non-surgical treatment for carpal tunnel syndrome? A systematic review.

Author: ShiQiyun, MacDermidJoy C

Carpal tunnel syndrome treatment

Carpal tunnel syndrome is a common condition treated with both surgery and non-surgical methods. While some cases clearly require surgery, there are many patients for whom either approach could be chosen. This review compares the effectiveness of surgery versus conservative treatment for carpal tunnel syndrome.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Comparison of local steroid injection into carpal tunnel via proximal and distal approach in patients with carpal tunnel syndrome.

Author: KamanliA, BezgincanM, KayaA

CTS treatment

Carpal tunnel syndrome (CTS) is a common nerve problem. While there are non-surgical treatments like wrist splints, physical therapy, and steroid injections, this study compares the effectiveness of injecting steroids into the carpal tunnel using two different approaches: one closer to the wrist and one further away from the wrist. The study focuses on people with CTS confirmed by nerve conduction studies.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

64.

Ergonomic positioning or equipment for treating carpal tunnel syndrome.

Author: O'ConnorDenise, PageMatthew J, MarshallShawn C, Massy-WestroppNicola

Treatment of carpal tunnel syndrome

People with mild to moderate carpal tunnel syndrome (CTS) are sometimes treated with ergonomic modifications, such as changing how they position their hands or using special equipment. However, the effectiveness and how long these interventions provide benefits are unknown.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Randomized controlled trial comparing acupuncture with placebo acupuncture for the treatment of carpal tunnel syndrome.

Author: YaoElisa, GerritzPeter K, HenricsonErik, AbreschTed, KimJorge, HanJay, WangKenten, ZhaoHolly

Improved CTS symptoms

Acupuncture was not shown to be superior to placebo acupuncture in treating mild to moderate carpal tunnel syndrome (CTS) in conjunction with bracing.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

66.

Comparison of carpal tunnel release with three different techniques.

Author: AslaniHamid Reza, AlizadehKhalil, EajaziAlireza, KarimiAmin, KarimiMohammad Hossein, ZaferaniZohreh, Hosseini KhamenehSeyed Mehdi

Improved early satisfaction
Reduced time to return to work

This clinical trial study compared the outcomes of regular open incision, mid-palmar mini incision, and endoscopic techniques for carpal tunnel release in 105 patients. Endoscopic and mini incision techniques demonstrated better early satisfaction rates than regular open incision. However, all three techniques showed similar outcomes after 4 months.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

67.

Exercise and mobilisation interventions for carpal tunnel syndrome.

Author: PageMatthew J, O'ConnorDenise, PittVeronica, Massy-WestroppNicola

Improved CTS symptoms
Limited evidence of effectiveness

There is limited and very low quality evidence of benefit for various exercise and mobilisation interventions for carpal tunnel syndrome (CTS). More high-quality randomized controlled trials are needed to assess the effectiveness and safety of these interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Treatment for ulnar neuropathy at the elbow.

Author: CaliandroPietro, La TorreGiuseppe, PaduaRoberto, GianniniFabio, PaduaLuca

Simple decompression efficacy
Subjective discomfort reduction
Transposition efficacy
Ulnar neuropathy treatment
Insufficient evidence
Wound infection risk

Simple decompression and decompression with transposition are equally effective in treating idiopathic ulnar neuropathy at the elbow.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

69.

Short-term results of endoscopic (Okutsu method) versus palmar incision open carpal tunnel release: a prospective randomized controlled trial.

Author: EjiriSoichi, KikuchiShin-ichi, MaruyaMasato, SekiguchiYasufumi, KawakamiRyoichi, KonnoShin-ichi

Treatment of CTS

This study compares two common surgical procedures for carpal tunnel syndrome (CTS) in Japan: endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR). The research compares the short-term outcomes of these two procedures in a controlled study.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

70.

Sensory relearning after surgical treatment for carpal tunnel syndrome: a pilot clinical trial.

Author: Jerosch-HeroldChristina, ShepstoneLee, MillerLeanne

Improved sensory relearning

A sensory relearning program showed potential benefit for patients with ongoing sensory deficits after carpal tunnel decompression. Further research is needed to confirm its efficacy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

71.

Anatomical basis of ulnar approach in carpal tunnel injection.

Author: KimDong Hwee, JangJi Eun, ParkByung Kyu

Carpal tunnel syndrome treatment
Median nerve injury
Ulnar artery injury

Injecting steroids into the wrist can be a helpful treatment for carpal tunnel syndrome. However, using a blind injection technique, where the needle isn't guided by imaging, can increase the risk of accidentally injuring the median nerve or ulnar artery due to swelling or their close proximity in the wrist.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

72.

Rehabilitation following carpal tunnel release.

Author: PetersSusan, PageMatthew J, CoppietersMichel W, RossMark, JohnstonVenerina

CTS recovery
Iatrogenic symptoms

A review of 20 trials found limited and low-quality evidence for the benefit of postoperative rehabilitation interventions following carpal tunnel syndrome (CTS) surgery. The decision to provide rehabilitation should be based on the clinician's expertise, the patient's preferences, and the context of the rehabilitation environment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

73.

A systematic review of the literature on the outcomes of treatment for recurrent and persistent carpal tunnel syndrome.

Author: SoltaniAli M, AllanBassan J, BestMatthew J, MirHaaris S, PanthakiZubin J

Carpal tunnel syndrome relief

Decompression with the use of vascularized flap coverage appears to have a higher success rate over simple repeated decompression in recurrent and persistent carpal tunnel syndrome.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Comparative analysis between minimal access versus traditional accesses in carpal tunnel syndrome: a perspective randomised study.

Author: TaralloMauro, FinoPasquale, SorvilloValentina, ParisiPaola, ScuderiNicolò

CTS treatment

Surgery to release the carpal tunnel, a common procedure for carpal tunnel syndrome, has been very successful. While a long incision is typically used, this study compares this traditional approach to a minimally invasive technique, both in terms of effectiveness and the authors' experience.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

75.

Endoscopic release for carpal tunnel syndrome.

Author: VasiliadisHaris S, GeorgoulasPetros, ShrierIan, SalantiGeorgia, ScholtenRob J P M

CTS treatment

Carpal tunnel syndrome, a common nerve condition in the hand, is caused by pressure on a nerve in the wrist. Surgery to relieve this pressure involves cutting the transverse carpal ligament. This can be done through a traditional open incision or using an endoscopic approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

Effectiveness of mechanical traction as a non-surgical treatment for carpal tunnel syndrome compared to care as usual: study protocol for a randomized controlled trial.

Author: MeemsMargreet, Den OudstenBrenda, MeemsBerend-Jan, PopVictor

CTS treatment

Carpal tunnel syndrome (CTS) is a common condition causing numbness, tingling, and pain in the hand. While surgery is often effective, it's invasive. Non-surgical options have limited success, especially long-term. Mechanical traction, a stretching technique, has shown promise. This study compares mechanical traction to standard care for CTS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

77.

Symptom severity and conservative treatment for carpal tunnel syndrome in association with eventual carpal tunnel release.

Author: BakerNancy A, LivengoodHeather M

The severity of carpal tunnel syndrome (CTS) symptoms and the lack of response to conservative treatment are associated with progression to surgery. In a secondary analysis of a randomized controlled trial, participants with more severe baseline symptoms and those who received additional conservative treatment were more likely to proceed to surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

78.

Endoscopic versus open carpal tunnel release for idiopathic carpal tunnel syndrome: a meta-analysis of randomized controlled trials.

Author: ZuoDongqing, ZhouZifei, WangHongsheng, LiaoYuxin, ZhengLongpo, HuaYingqi, CaiZhengdong

CTS treatment
Postoperative nerve injury

This study compared two surgical approaches for carpal tunnel syndrome: endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR). The study found no significant difference in overall complication rates, patient satisfaction, time to return to work, hand strength, or surgery time between the two methods. However, ECTR was associated with less hand pain after surgery but a higher risk of temporary nerve damage compared to OCTR.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

EARLY RESPONSE OF LOCAL STEROID INJECTION VERSUS MINI INCISION TECHNIQUE IN TREATMENT OF CARPAL TUNNEL SYNDROME.

Author: AwanAbdus Saboor, KhanAlamzeb, AfridiSikandar Aziz, KhanInam Ullah, BhattiSajid Nazir, AhmedEhtisham, MuhammadGul, KhanRao Suhail, SultanShahid, LodhiFahad Saqib

CTS treatment

Carpal tunnel syndrome (CTS), a common nerve condition, is more common in middle-aged women. This study compares the effectiveness of injecting steroids into the wrist and using a smaller incision during surgery for carpal tunnel syndrome, specifically focusing on reducing post-operative pain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

80.

Similar effectiveness of the open versus endoscopic technique for carpal tunnel syndrome: a prospective randomized trial.

Author: GümüştaşSeyit Ali, EkmekçiBurcu, TosunHaci Bayram, OrakMehmet Müfit, BeklerHalil İbrahim

Carpal tunnel syndrome treatment

This study compared the effectiveness of two surgical procedures for carpal tunnel syndrome: endoscopic surgery and open surgery. Both types of surgery showed significant improvement in symptoms and function, with no significant difference between the two approaches. Electrophysiological tests also showed similar improvements in both groups. This suggests that endoscopic carpal tunnel surgery is as effective as traditional open surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

81.

Endoscopic and Open Release Similarly Safe for the Treatment of Carpal Tunnel Syndrome. A Systematic Review and Meta-Analysis.

Author: VasiliadisHaris S, NikolakopoulouAdriani, ShrierIan, LunnMichael P, BrassingtonRuth, ScholtenRob J P, SalantiGeorgia

Carpal tunnel treatment
ECTR complications

Endoscopic carpal tunnel release (ECTR) is a minimally invasive treatment for carpal tunnel syndrome. Some question its safety due to its "blind" nature and the number of serious complications reported.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Rehabilitation following carpal tunnel release.

Author: PetersSusan, PageMatthew J, CoppietersMichel W, RossMark, JohnstonVenerina

Carpal tunnel syndrome treatment
Carpal tunnel syndrome surgery

There is limited and low-quality evidence for the effectiveness of rehabilitation interventions following carpal tunnel syndrome (CTS) surgery. More high-quality trials are needed to evaluate the benefits of various rehabilitation treatments and to identify patients who respond to specific interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Conservative treatment in patients with mild to moderate carpal tunnel syndrome: A systematic review.

Author: Jiménez Del BarrioS, Bueno GraciaE, Hidalgo GarcíaC, Estébanez de MiguelE, Tricás MorenoJ M, Rodríguez MarcoS, Ceballos LaitaL

CTS treatment

Carpal tunnel syndrome (CTS), the most common nerve disorder, affects the median nerve in the wrist. Severe cases are usually treated with surgery, while mild to moderate CTS is often managed with non-surgical treatments. This review examines conservative treatment options for CTS over the past 15 years to evaluate their effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Kinesiotaping as an alternative treatment method for carpal tunnel syndrome.

Author: Geler KülcüDuygu, BursaliCanan, Aktaşİlknur, Bozkurt AlpSelin, Ünlü ÖzkanFeyza, AkpinarPınar

CTS treatment

Carpal tunnel syndrome (CTS), a common nerve disorder, is often difficult to manage with conservative treatments. This study compared the effectiveness of kinesiotaping (KT), a type of taping used to support muscles and joints, to placebo KT and orthotic devices (ODs) in treating CTS. The study evaluated the impact on pain, grip strength, and overall function in patients with CTS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

85.

Z-Elongation of the transverse carpal ligament vs. complete resection for the treatment of carpal tunnel syndrome.

Author: Castro-MenéndezM, Pagazaurtundúa-GómezS, Pena-PazS, Huici-IzcoR, Rodríguez-CasasN, Montero-ViéitesA

Carpal tunnel syndrome treatment

Surgery to release the transverse carpal ligament (TCL) is effective for carpal tunnel syndrome, but can sometimes cause persistent weakness, pain, and other complications. This research explores different techniques for reconstructing or lengthening the ligament to reduce these complications.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

86.

Education, night splinting and exercise versus usual care on recovery and conversion to surgery for people awaiting carpal tunnel surgery: a protocol for a randomised controlled trial.

Author: LewisKarina J, RossLeo, CoppietersMichel W, VicenzinoBill, SchmidAnnina B

CTS treatment

Carpal tunnel syndrome (CTS) is a common problem affecting the hand and wrist, causing significant costs to individuals and society. Long wait times and traditional healthcare systems often delay treatment. This study explores alternative ways to improve access to treatment and reduce the need for surgery.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

87.

Efficacy, safety, and cost of surgical versus nonsurgical treatment for carpal tunnel syndrome: A systematic review and meta-analysis.

Author: RenYi-Ming, WangXi-Shan, WeiZhi-Jian, FanBao-You, LinWei, ZhouXian-Hu, FengShi-Qing

CTS treatment

Carpal tunnel syndrome (CTS) is a common nerve disorder in the wrist. This review compares the effectiveness, safety, and cost of surgery versus non-surgical treatments for CTS.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Retracted PublicationCases where a publication has been formally withdrawn due to the discovery of serious errors or misconduct.

Language : English

88.

Treatment for ulnar neuropathy at the elbow.

Author: CaliandroPietro, La TorreGiuseppe, PaduaRoberto, GianniniFabio, PaduaLuca

Nerve function increase
Symptom reduction
Hematoma
Ulnar neuropathy
Wound infections

Simple decompression and decompression with transposition are equally effective in idiopathic ulnar neuropathy at the elbow (UNE), including when the nerve impairment is severe. Decompression with transposition is associated with more deep and superficial wound infections than simple decompression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

The effectiveness of low-level laser therapy on pain, self-reported hand function, and grip strength compared to placebo or "sham" treatment for adults with carpal tunnel syndrome: A systematic review.

Author: BurgerMarlette, KrielRéna, DamonAndrea, AbelAmy, BansdaAnisha, WakensMarinique, ErnstzenDawn

LLLT for CTS

This systematic review of nine randomized controlled trials found that there is no strong evidence concerning the effects of Low-Level Laser Therapy on carpal tunnel syndrome in adults.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

The Incidence of Complex Regional Pain Syndrome in Simultaneous Surgical Treatment of Carpal Tunnel Syndrome and Dupuytren Contracture.

Author: BullerMitchell, SchulzSteven, KasdanMorton, WilhelmiBradon J

Simultaneous surgery
CRPS risk

Adding carpal tunnel release to patients undergoing fasciectomy for Dupuytren contracture resulted in a marginal increase in the occurrence of complex regional pain syndrome (CRPS), indicating that no clear clinical risk is associated with simultaneous surgical treatment of both conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

91.

Efficacy of paraffin wax bath for carpal tunnel syndrome: a randomized comparative study.

Author: OrdahanBanu, KarahanAli Yavuz

CTS treatment

This study compared the effectiveness of splinting alone and splinting combined with paraffin wax therapy for carpal tunnel syndrome (CTS). Both treatments reduced pain, but combining paraffin wax with splinting led to greater improvements in hand function and nerve function as measured by electrophysiological tests.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

93.

Mechanical wrist traction as a non-invasive treatment for carpal tunnel syndrome: a randomized controlled trial.

Author: MeemsMargreet, SpekViola, KopWillem J, MeemsBerend-Jan, VisserLeo H, PopVictor J M

CTS treatment

Carpal tunnel syndrome (CTS) is a common nerve disorder that causes numbness, tingling, and pain in the hand. While surgery is the most effective long-term treatment, it can have complications. This study investigates the effectiveness of mechanical wrist traction as a non-surgical treatment for CTS compared to standard care.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

94.

Safety and efficacy of platelet-rich plasma in treatment of carpal tunnel syndrome; a randomized controlled trial.

Author: RaeissadatSeyed Ahmad, KarimzadehAfshin, HashemiMasoud, BagherzadehLeila

Carpal tunnel syndrome treatment
Platelet-rich plasma
Limited evidence

Carpal tunnel syndrome, a common nerve compression condition, is often treated with non-surgical methods. However, these treatments are not always effective. Platelet-rich plasma (PRP), which contains growth factors, has been explored as a potential treatment for carpal tunnel syndrome, but more research is needed to confirm its benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

95.

Comparison of the effectiveness of orthotic intervention, kinesiotaping, and paraffin treatments in patients with carpal tunnel syndrome: A single-blind and randomized controlled study.

Author: Mansiz KaplanBasak, AkyuzGulseren, KokarSerdar, YagciIlker

CTS pain reduction
Median nerve size reduction

Kinesiotaping added to night use of an orthotic was more effective in reducing pain and improving structural changes in patients with mild to moderate carpal tunnel syndrome than either the orthotic alone or paraffin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

96.

Ultra-micronized Palmitoylethanolamide Effects on Sleep-wake Rhythm and Neuropathic Pain Phenotypes in Patients with Carpal Tunnel Syndrome: An Open-label, Randomized Controlled Study.

Author: EvangelistaMaurizio, Cilli, De VitisR, MiliternoA, FanfaniF

Carpal tunnel syndrome treatment
Palmitoylethanolamide

This study examined whether ultramicronized palmitoylethanolamide can reduce pain and improve sleep quality in people with carpal tunnel syndrome, a condition that often causes disrupted sleep.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

97.

Comparison of the Short-Term and Long-Term Effects of Surgery and Nonsurgical Intervention in Treating Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis.

Author: ShiQiyun, BobosPavlos, LaloneEmily A, WarrenLaura, MacDermidJoy C

CTS treatment
Conservative interventions
Surgical interventions

This study compared surgery to conservative treatments (splinting, steroid injections, or physical therapy) for carpal tunnel syndrome (CTS). Surgery was found to be more effective than conservative treatments after 6 months, improving hand function and reducing symptoms, and also showed better nerve function. There was no significant difference between the treatments at 3 or 12 months. More research is needed to understand long-term outcomes.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

The comparison of limited-incision versus standard-incision in treatment of carpal tunnel syndrome: A meta-analysis of randomized controlled trials.

Author: LiGaocen, KongLingde, KouNingzhao, WangYanxue, YuKunlun, BaiJiangbo, TianDehu

Faster return to activities
Improved early strength recovery
Reduced adverse events
Reduced operative time

Limited incision carpal tunnel release allows for earlier return to activities, reduces operative time, decreases the rate of adverse events, and improves strength during the early postoperative period. Results at 6 months or longer are similar according to current data.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

99.

Platelet-rich plasma in treatment of patients with idiopathic carpal tunnel syndrome.

Author: SennaMohammad K, ShaatReham M, AliAlaa Ali Awad

CTS treatment
PRP

Carpal tunnel syndrome (CTS) is a common nerve disorder in the hand and wrist. While treatments range from conservative options to surgery, some studies suggest that injecting platelet-rich plasma (PRP) into the area might be a helpful treatment. More research is needed to confirm its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

100.

Carpal Tunnel Release Surgery Plus Intraoperative Corticosteroid Injection versus Carpal Tunnel Release Surgery Alone: A Double Blinded Clinical Trial.

Author: MottaghiMohammad, ZareMostafa, PahlavanhosseiniHamid, MottaghiMina

CTR
Carpal tunnel syndrome treatment
Local corticosteroid injection

This study compared the outcomes of carpal tunnel release surgery with and without a steroid injection. The study found no significant difference in nerve function or symptom severity between the two groups, suggesting that adding a steroid injection to carpal tunnel surgery doesn't improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

101.

Acupuncture for Carpal Tunnel Syndrome: A Randomized Controlled Trial Studying Changes in Clinical Symptoms and Electrodiagnostic Tests.

Author: Bahrami-TaghanakiHamidreza, AziziHoda, HasanabadiHosein, JokarMohamad Hassan, IranmaneshAmir, Khorsand-VakilzadehAli, Badiee-AvalShapour

Improved motor function
Improved symptoms
Nerve repair

Carpal tunnel syndrome (CTS) is a common nerve disorder in the wrist. While various non-surgical treatments are used, including splinting, steroid injections, and ultrasound, there is limited evidence on the effectiveness of acupuncture and electroacupuncture for CTS. These treatments may help to improve symptoms, nerve function, and sensation, but more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

102.

A comparative study of the dose-dependent effects of low level and high intensity photobiomodulation (laser) therapy on pain and electrophysiological parameters in patients with carpal tunnel syndrome.

Author: EzzatiKamran, LaaksoE-Liisa, SaberiAlia, Yousefzadeh ChabokShahrokh, NasiriEbrahim, Bakhshayesh EghbaliBabak

Nerve conduction improvement
Pain reduction

Low-level laser therapy (LLLT) and high-intensity laser therapy (HILT) were effective in reducing pain and improving median motor nerve conduction studies in patients with carpal tunnel syndrome (CTS). HILT with a power of 1.6 W and low fluence of 8 J/cm2 was more effective than LLLT and exercise interventions.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

103.

Efficacy of Hyalase Hydrodissection in the Treatment of Carpal Tunnel Syndrome: A Randomized, Double-Blind, Controlled, Clinical Trial.

Author: ElawamyAbdelraheem, HassanienManal, HamedAhmed, RoushdyAl Shimaa Ismael, AbassNisreen Adel, MohammedGhada, HasanMohamed Raouf Abdel Razek, KamelEmad Zarief

CTS treatment

Carpal tunnel syndrome (CTS) is a common condition caused by pressure on a nerve in the wrist. Many non-surgical treatments are available for mild to moderate cases. A new approach, using Hyalase to break down tissue around the compressed nerve, shows promise in providing lasting relief from symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

104.

Open versus endoscopic carpal tunnel release: a systematic review and meta-analysis of randomized controlled trials.

Author: LiYueying, LuoWenqi, WuGuangzhi, CuiShusen, ZhangZhan, GuXiaosong

Faster return to work
Improved daily life functions
Increased satisfaction
Reduced scar complications
Increased transient nerve injury

A meta-analysis of 28 studies comparing endoscopic carpal tunnel release (ECTR) and open carpal tunnel release (OCTR) found that ECTR resulted in better recovery of daily life functions, with higher satisfaction rates, greater key pinch strengths, earlier return to work times, and fewer scar-related complications. These findings suggest that patients with carpal tunnel syndrome (CTS) can be effectively managed with ECTR.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

105.

Effective self-stretching of carpal ligament for the treatment of carpal tunnel syndrome: A double-blinded randomized controlled study.

Author: ShemKazuko, WongJoseph, DirlikovBenjamin

Symptom improvement

A prospective, double-blinded, randomized, placebo-controlled trial of 83 participants with carpal tunnel syndrome (CTS) found that myofascial stretching of the carpal ligament showed statistically significant symptom improvement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

106.

Comparative efficacy of the dorsal application of Kinesio tape and splinting for carpal tunnel syndrome: A randomized controlled trial.

Author: KrauseDonnamarie, RollShawn C, Javaherian-DysingerHeather, DaherNoha

CTS treatment

Carpal tunnel syndrome (CTS) can be difficult to treat when symptoms are not severe enough for surgery. While various conservative treatments exist with mixed results, kinesio tape, a type of elastic tape, is emerging as a potential option because it supports the wrist and allows for movement.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

107.

Comparison of low power laser and kinesio taping for the treatment of carpal tunnel syndrome: A prospective randomized study.

Author: AkgolGurkan, ElbastiMuhammet Sahin, GulkesenArif, AlkanGokhan, KayaArzu, UlusoyHasan

BQ improvement
CTS treatment
DN4 improvement
HGS improvement
VAS-pain improvement
Carpal tunnel syndrome

This study compared the effectiveness of low power laser therapy (LPLT) and Kinesio taping (KT) for treating carpal tunnel syndrome (CTS). Both LPLT and KT were effective in improving hand grip strength, pain, and other symptom measures. However, LPLT showed significantly better improvements in all measures compared to KT. This suggests that LPLT may be a more effective treatment option for CTS.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

108.

Effectiveness of Conservative Treatment According to Severity and Systemic Disease in Carpal Tunnel Syndrome: A Systematic Review.

Author: Hernández-SecorúnMar, Montaña-CortésRaquel, Hidalgo-GarcíaCésar, Rodríguez-SanzJacobo, Corral-de-ToroJaime, Monti-BallanoSofia, Hamam-AlcoberSami, Tricás-MorenoJosé Miguel, Lucha-LópezMaría Orosia

CTS treatment

Carpal tunnel syndrome (CTS) is a common nerve problem in the wrist. While non-surgical treatments have helped people with mild to moderate CTS, there's not enough research on people with severe CTS or those with other health conditions. This review found that medications, manual therapy (like massage), and electrical stimulation can help with CTS, but we don't know the best combination. Future research should include more people with severe CTS and other health conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

Nonsurgical Treatment for Symptomatic Carpal Tunnel Syndrome: A Randomized Clinical Trial Comparing Local Corticosteroid Injection Versus Night Orthosis.

Author: de MoraesVinícius Ynoe, QueirozJesus, Raduan-NetoJorge, FernandesMarcela, OkamuraAldo, BellotiJoão Carlos

Improved BLQ scores
Improved paresthesia
Reduced pain

Corticosteroid injection was superior to orthosis for improving carpal tunnel syndrome (CTS)-related nocturnal paresthesia, Boston-Levine questionnaire (BLQ) scores, and pain. Both options were effective in the short term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

110.

Effectiveness of Tendon and Nerve Gliding Exercises in the Treatment of Patients With Mild Idiopathic Carpal Tunnel Syndrome: A Randomized Controlled Trial.

Author: AbdolrazaghiHossein Ali, KhansariMahmoud, MirshahiMaryam, Ahmadi PishkuhiMahin

Improved function
Symptom relief
No additional benefit

Both gliding exercise and wrist splint groups showed improvement in the severity of symptoms and functional status scores, but gliding exercises did not offer additional benefit compared with wrist splint alone.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

111.

Kinesio taping as an alternative treatment for manual laborers with carpal tunnel syndrome: A double-blind randomized clinical trial.

Author: Aminian-FarAtefeh, PahlevanDaryoush, KohnegiFatemeh Maleki

CTS treatment

Kinesio taping (KT) is an effective, safe, reliable, and conservative treatment for mild to moderate carpal tunnel syndrome (CTS). It significantly improved electrophysiological and functional outcomes compared to sham taping in 30 Iranian manual laborers with CTS. The treatment does not restrict daily activities and has no side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

112.

Flexor Synovectomy as an Adjunct to Carpal Tunnel Release in Primary Carpal Tunnel Syndrome: A Meta-Analysis.

Author: ChiangJenny, AnVincent Vinh Gia, GrahamDavid, LawsonRichard, SivakumarBrahman

CTR effectiveness

Carpal tunnel syndrome (CTS) is treated by releasing pressure on the nerve in the wrist (carpal tunnel release or CTR). Sometimes, doctors also remove the lining of the tendons in the wrist (flexor tenosynovectomy or FS). This review found that adding FS to CTR didn't improve grip strength, symptoms, function, or nerve function, and didn't reduce complications. It suggests that FS is not necessary for most people with CTS. More research is needed to confirm these findings. FS may be helpful for people who have had CTS before or whose CTS is caused by something other than the carpal tunnel.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

113.

A Systematic Review of the Outcomes of Carpal Ligament Release in Severe Carpal Tunnel Syndrome.

Author: MeyersAbigail, AnnunziataMichael J, RampazzoAntonio, Bassiri GharbBahar

CTS treatment
Unpredictable outcomes

This systematic review found that carpal tunnel release in patients with severe carpal tunnel syndrome (CTS) is associated with symptomatic improvement. However, patients should be counseled about the unpredictability of the outcomes and factors that might affect outcomes.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

114.

A Systematic Review of Randomised Control Trials Evaluating the Efficacy and Safety of Open and Endoscopic Carpal Tunnel Release.

Author: MacDonaldEilidh, ReaPaul M

Carpal tunnel syndrome treatment

Carpal tunnel syndrome (CTS) is a common nerve problem in the wrist. Doctors debate whether a traditional open surgery or a minimally invasive procedure (endoscopic surgery) is better for treating CTS. This review will examine research comparing the effectiveness and safety of these two approaches.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

115.

Ultrasound-guided percutaneous carpal tunnel release: A systematic review.

Author: ChouRaymond C, RobinsonDavid M, HomerScott

Effective treatment
Short recovery time
Compartment syndrome
Minor complications

Ultrasound-guided percutaneous carpal tunnel release (USCTR) may be an effective treatment for carpal tunnel syndrome (CTS), with potential for short post-procedure recovery times. However, the evidence supporting this claim is very low, and further research is needed.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

116.

[Physiotherapy and sports therapeutic interventions for treatment of carpal tunnel syndrome : A systematic review].

Author: GräfJulia Katharina, LüdtkeKerstin, WollesenBettina

CTS treatment
Improved function
Reduced pain

This systematic review found that physiotherapy and sports therapeutic interventions are effective in treating mild to moderate carpal tunnel syndrome (CTS). These interventions can be as effective as surgery and are associated with a lower risk of side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

117.

Comparative Efficacy of Routine Physical Therapy with and without Neuromobilization in the Treatment of Patients with Mild to Moderate Carpal Tunnel Syndrome.

Author: IjazMuhammad Junaid, KarimiHossein, AhmadAshfaq, GillaniSyed Amer, AnwarNaveed, ChaudharyMuhammad Asad

Improved functional status
Improved muscle strength
Improved pain
Improved range of motion

This study compared the effectiveness of median nerve neuromobilization at the wrist versus routine physical therapy in treating carpal tunnel syndrome. Both groups showed improvement, but the neuromobilization group had greater improvement in range of motion, pain, symptom severity, functional status, and overall Boston Carpal Tunnel Syndrome Questionnaire scores.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

118.

Manual Therapy and Related Interventions for Carpal Tunnel Syndrome: A Systematic Review and Meta-Analysis.

Author: DuJihang, YuanQiang, WangXiao-Yan, QianJun-Hui, AnJie, DaiQian, YanXiang-Yun, XuBojun, LuoJian, WangHao-Zhong

Improved CTS symptoms
Improved hand function

This review found that manual therapy (including massage, stretching, and joint mobilization) was more effective than standard care in treating carpal tunnel syndrome (CTS). Manual therapy improved both symptom severity and hand function in people with CTS. The review suggests that manual therapy should be considered as a clinically effective treatment for CTS.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

119.

Outcomes of bilateral carpal tunnel syndrome treatment - A systematic review and meta-analysis.

Author: GeorgetoS M, PicharskiG L, AndrausR A C, da SilvaR A, NgomoS, FernandesK B P

Improved CTS symptoms
Improved hand function
Improved pain

Carpal tunnel syndrome (CTS) is a common nerve problem that affects both wrists. This review found that both non-surgical and surgical treatments for CTS improved symptoms, function, and pain levels after one and three months. Non-surgical treatments involved things like medication, physical therapy, and wrist braces. Surgical treatments included both traditional open surgery and a minimally invasive approach (endoscopic surgery). While both approaches showed improvement, surgery was generally more effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

Diacutaneous Fibrolysis Intervention in Patients with Mild to Moderate Carpal Tunnel Syndrome May Avoid Severe Cases in Elderly: A Randomized Controlled Trial.

Author: Jiménez-Del-BarrioSandra, Ceballos-LaitaLuis, Bueno-GraciaElena, Rodríguez-MarcoSonia, Caudevilla-PoloSantos, Estébanez-de-MiguelElena

CTS treatment

Carpal tunnel syndrome (CTS) is a common nerve problem in the wrist that often affects adults who work. It's more common in older people. Guidelines recommend starting with non-surgical treatments. This study will assess a treatment called Diacutaneous Fibrolysis (DF) to see how it affects the size of the median nerve, the thickness of the ligament that surrounds the nerve, numbness, and how people feel after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

121.

Trial of ultrasound guided carpal tunnel release versus traditional open release (TUTOR).

Author: EberlinKyle R, DyChristopher J, FischerMark D, GluckJames L, KaplanF Thomas D, McDonaldThomas J, MillerLarry E, PalmerAlexander, WalkerMarc E, WattJames F

CTS treatment

This study will compare two surgical techniques for treating carpal tunnel syndrome (CTS): surgery using ultrasound guidance (CTR-US) and a less invasive approach called mini-open CTR (mOCTR). The study aims to determine which technique is safer and more effective for patients with CTS who haven't responded to other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

122.

Quality analysis of prior systematic reviews of carpal tunnel syndrome: an overview of the literature.

Author: CavalcanteMarcelo Cortês, MoraesVinicius Ynoe de, OsésGuilherme Ladeira, NakachimaLuis Renato, BellotiJoão Carlos

Improved treatment decisions
Poor quality reviews

The quality of systematic reviews on the treatment of carpal tunnel syndrome was generally poor. Higher-quality reviews conducted meta-analysis and included randomized controlled trials.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

123.

Local corticosteroid injection versus placebo for carpal tunnel syndrome.

Author: AshworthNigel L, BlandJeremy D P, ChapmanKristine M, TardifGaetan, AlbarqouniLoai, NagendranArjuna

CTS treatment

Carpal tunnel syndrome (CTS) is a common nerve problem in the wrist. Treatment for CTS is expensive, costing billions of dollars annually in the U.S. Cortisone injections are often used as a non-surgical treatment for CTS, but their effectiveness is still debated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

124.

Effects of repetitive peripheral magnetic stimulation <i>vs</i>. conventional therapy in the management of carpal tunnel syndrome: a pilot randomized controlled trial.

Author: PanathoopArachaphon, SaengsuwanJittima, VichiansiriRatana

CTS treatment

Carpal tunnel syndrome (CTS) is a common nerve problem that causes pain, numbness, and weakness in the hand, making it difficult to do everyday things. A new treatment called repetitive peripheral magnetic stimulation (rPMS) might be helpful for CTS. This study will compare rPMS to standard treatments for CTS to see which works better.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

125.

Clinical usefulness of nutraceutics with acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, C, E and B-group vitamins in patients awaiting for carpal tunnel release during COVID-19 pandemic: a randomized controlled open label prospective study.

Author: D'OrioMarco, De VitisRocco, TaccardoGiuseppe, RocchiLorenzo, FerrariFederico, PernaAndrea, PassiatoreMarco

CTS treatment

Carpal tunnel syndrome (CTS) occurs when the median nerve in the wrist is compressed. This study will examine the effectiveness of a specific dietary supplement containing acetyl-L-carnitine, α-lipoic acid, phosphatidylserine, curcumin, vitamins C, E, and B vitamins in people with mild to moderate CTS.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

126.

Evaluating the Effect of Pregabalin in the Treatment of Carpal Tunnel Syndrome: A Prospective, Randomized, Triple-Blinded, Placebo-controlled Trial.

Author: BismayaKumar, SinghVarun Kumar, PathakAbhishek, KumarAnand, MishraVijaya Nath, JoshiDeepika, ChaurasiaRameshwar Nath

CTS symptom relief
Improved function

Pregabalin is effective in controlling symptoms and improving functional outcomes in mild to moderate idiopathic carpal tunnel syndrome (CTS). This study found significant improvements in symptom severity, functional status, and clinical and electrophysiological grading in patients treated with pregabalin compared to placebo.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

128.

Efficacy of splinting the wrist and metacarpophalangeal joints for the treatment of Carpal tunnel syndrome: an assessor-blinded randomised controlled trial.

Author: NadarMohammed Sh, AlotaibiNaser, ManeeFahad

Improved grip strength
Improved pinch strength
Improved two-point discrimination
Reduced Phalen's manoeuvre symptoms

This randomized clinical trial found that a wrist splint that incorporates the metacarpophalangeal (MCP) joints is more effective than a traditional wrist-only splint for treating carpal tunnel syndrome (CTS).

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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