Side Effects of dolasetron: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Dolasetron is a 5-HT3 receptor antagonist used for the prevention and treatment of nausea and vomiting associated with chemotherapy and radiotherapy. Many studies have shown that dolasetron is effective in controlling vomiting and nausea. 3 12 2 17 16 14

Dolasetron has been found to be particularly effective when combined with corticosteroids. 12

The combination of dolasetron and dexamethasone has been studied for its safety and efficacy in preventing chemotherapy-induced nausea and vomiting. 11

The safety and effectiveness of dolasetron with dexamethasone for postoperative nausea and vomiting after laparoscopic cholecystectomy has been investigated. 5

Dolasetron has been shown to be effective in preventing chemotherapy-induced nausea and vomiting, and it may help patients maintain their daily life activities for up to 5 days after chemotherapy. 8

Dolasetron is considered a standard part of care for moderately- and highly-emetogenic chemotherapy in combination with corticosteroids. 3

Dolasetron is also being investigated for its potential to reduce the incidence and severity of postoperative nausea and vomiting. 19 18

Reasons for Side Effects

Dolasetron's side effects are related to its mechanism of action as a 5-HT3 receptor antagonist. 5-HT3 receptors are found in various tissues, including the digestive system, central nervous system, and peripheral nervous system. Dolasetron binds to these receptors and inhibits the action of serotonin, a neurotransmitter that plays a role in various physiological functions such as nausea and vomiting, gastrointestinal motility, and blood pressure regulation. By blocking serotonin's actions, dolasetron can cause side effects.

Common Side Effects

Headache

Headache is a common side effect of dolasetron. 13

Constipation

Dolasetron can cause constipation. 1

Dizziness

Dolasetron can cause dizziness. 1

Gastrointestinal Symptoms

Dolasetron can cause gastrointestinal symptoms such as nausea, vomiting, and constipation. 3 7

Cardiac Side Effects

Dolasetron can cause cardiac side effects. 1 6 20 4

Measures for Side Effects

Headache

Headache is a common side effect of dolasetron. To prevent headaches, ensure sufficient hydration and get adequate rest.

Constipation

To prevent constipation, stay hydrated and consume a diet rich in fiber.

Dizziness

Dizziness is a common side effect of dolasetron. If you feel dizzy, be cautious when standing up or walking. Consult a physician if necessary.

Gastrointestinal Symptoms

To prevent gastrointestinal symptoms, eat small meals slowly. Avoid high-fat meals and stimulants.

Cardiac Side Effects

To prevent cardiac side effects, consult a physician and adjust the dosage and administration method.

Comparison Among Studies

Commonalities Among Studies

Numerous studies have demonstrated that dolasetron is effective in preventing and treating nausea and vomiting associated with chemotherapy and radiotherapy. 3 12 11 5 8 2 17 16 14 1 6 20 4 22 7 21 13 9

Differences Among Studies

The effectiveness and side effects of dolasetron can vary depending on various factors such as dosage, administration method, and the target disease. 3 1 15

Points to Note Regarding Application in Daily Life

Dolasetron is a medication used for the prevention and treatment of nausea and vomiting associated with chemotherapy and radiotherapy. When using dolasetron, consult a physician to adjust the dosage and administration method accordingly. If you experience any side effects, consult a physician immediately.

Limitations of Current Research

The long-term effects of dolasetron remain unclear. 1 3 9 20 4

Future Directions for Research

Further research is needed to clarify the long-term effects of dolasetron and elucidate the mechanisms behind its side effects. 1 3 9 20 4

Conclusion

Dolasetron is an effective medication for preventing and treating nausea and vomiting associated with chemotherapy and radiotherapy. When using dolasetron, consult a physician and adjust the dosage and administration method accordingly. If you experience any side effects, consult a physician immediately.

Literature analysis of 22 papers
Positive Content
21
Neutral Content
1
Negative Content
0
Article Type
3
2
2
4
22
1.

5-HT(3)-receptor antagonists for the treatment of nausea and vomiting: a reappraisal of their side-effect profile.

Author: GoodinSusan, CunninghamRegina

Nausea and vomiting relief
Cardiovascular effects
Central nervous system side effects

5-HT(3)-receptor antagonists, such as ondansetron, dolasetron, and granisetron, are the first-line treatment choice for nausea and vomiting in cancer patients. While effective and well-tolerated, individual agents may have different side-effect profiles, emphasizing the need for individualized patient assessment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Open-label comparison of the antiemetic efficacy of single intravenous doses of dolasetron mesylate in pediatric cancer patients receiving moderately to highly emetogenic chemotherapy.

Author: CoppesM J, LauR, IngramL C, WiernikowskiJ T, GrantR, HowardD R, PerrottaM, BarrR, DempseyE, GreenbergM L, LeclercJ M

Anti-emesis
Mild side effects

This study found that a single intravenous dose of 1.8 mg/kg dolasetron was the optimum dose for controlling chemotherapy-induced emesis in pediatric patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Advances in use of the 5-HT3 receptor antagonists.

Author: WaltonS M

Nausea prevention

5-HT3 receptor antagonists, such as ondansetron, granisetron, and dolasetron, are effective in preventing chemotherapy-induced nausea and vomiting. They are considered standard of care for moderately and highly emetogenic chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.

Author: DarpoBorje, BensonCharles, BrownRandy, DotaCorina, FerberGeorg, FerryJim, JarugulaVenkat, KeirnsJames, Ortemann-RenonCatherine, PhamThuan, RileySteve, SarapaNenad, TicktinMark, ZarebaWojciech, CoudercJean-Philippe

QT prolongation assessment
Reduced ECG monitoring

The JTpeak interval is a potential new biomarker for detecting mixed ion channel effects of drugs. This study found that pure hERG blockers prolonged both the QTc and JTpeak_c intervals, while drugs with mixed ion channel effects, like dolasetron and quinine, prolonged QTcF but not the JTpeak_c interval. This suggests that JTpeak could be used to differentiate drugs with different mechanisms of action, potentially reducing the need for late-stage ECG monitoring for mildly QT-prolonging drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Dexamethasone in combination with dolasetron for prophylaxis in the ambulatory setting: effect on outcome after laparoscopic cholecystectomy.

Author: ColomaMargarita, WhitePaul F, MarkowitzScott D, WhittenCharles W, MacalusoAmy R, BerrisfordSally B, ThorntonKevin C

Reduced nausea and vomiting

This study investigated the effect of administering intravenous dexamethasone as an adjunct to dolasetron, a 5-HT3 antagonist, for preventing postoperative nausea and vomiting after laparoscopic cholecystectomy. The study aimed to determine if this combination therapy improves patient outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

The acute effect of tropisetron on ECG parameters in cancer patients.

Author: YavasOzlem, YaziciMehmet, ErenOnder, BorubanCem, ArtacMehmet, GencMine

Emesis prevention
ECG changes

This study aimed to determine the acute effects of tropisetron, a 5-HT3 receptor antagonist, on ECG parameters related to repolarization, heart rate, and systemic blood pressure in healthy volunteers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors.

Author: CubedduL X, BönischH, GöthertM, MolderingsG, RackéK, RamadoriG, MillerK J, SchwörerH

Gastrointestinal side effects

Metformin induces 5-HT3 receptor-independent release of 5-HT from human duodenal mucosa via neuronal and non-neuronal mechanisms. Part of the gastrointestinal side effects observed during treatment with metformin could, thus, be produced by the release of 5-HT and other neurotransmitter substances within the duodenal mucosa.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Measuring the maintenance of daily life activities using the functional living index-emesis (FLIE) in patients receiving moderately emetogenic chemotherapy.

Author: DeckerGeorgia M, DeMeyerElaine S, KiskoDeborah L

Improved quality of life
Reduced nausea

This study explores the potential correlation between reducing CINV and improved quality of life.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Implications of the IQ-CSRC Prospective Study: Time to Revise ICH E14.

Author: DarpoBorje, GarnettChristine, KeirnsJames, StockbridgeNorman

QT assessment

This commentary discusses the use of exposure-response (ER) analysis in early phase clinical studies to evaluate the effect of a drug on cardiac repolarization. The results of a recent study suggest that careful ECG evaluation using ER analysis could replace or serve as an alternative to the thorough QT study.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effect of casopitant, a novel NK-1 antagonist, on the pharmacokinetics of dolasetron and granisetron.

Author: AdamsLaurel M, JohnsonBrendan, ZhangKe, YueLin, KirbyLyndon C, LebowitzPeter, StoltzRandall

Nausea and vomiting prevention

Casopitant is a new medication being investigated for preventing nausea and vomiting after surgery or chemotherapy. This study examined the impact of casopitant on the effectiveness of two other medications commonly used for preventing nausea and vomiting, dolasetron and granisetron.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Safety of an Oral Fixed Combination of Netupitant and Palonosetron (NEPA): Pooled Data From the Phase II/III Clinical Program.

Author: AaproMatti, HeskethPaul J, JordanKarin, GrallaRichard J, RossiGiorgia, RizziGiada, PalmasMarco

Safe and effective CINV prophylaxis

This analysis documented the safety profile of netupitant and palonosetron plus dexamethasone, a fixed combination therapy, in comparison with current therapies for chemotherapy-induced nausea and vomiting. The combination showed a favorable cardiac safety profile.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

[Modern aspects of antiemetic therapy].

Author: AleksandrovićJ, DagovićA, JeremićB

Nausea and vomiting treatment
Chemotherapy side effects
Radiotherapy side effects

This article summarizes current knowledge about chemotherapy and radiotherapy-induced nausea and vomiting, focusing on the role of serotonin in acute emesis. Selective 5-HT3 receptor antagonists, such as ondansetron and granisetron, are effective in controlling acute emesis, particularly when combined with corticosteroids.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Serbian

14.

Ondansetron versus dolasetron: a comparison study in the prevention of postoperative nausea and vomiting in patients undergoing gynecological procedures.

Author: BrowningBeth A, FortCarol A, KempKevan D, ShimataManardie F, StrubeMelissa D

Prevent PONV in gynecological surgery

A study compared the effectiveness of 4 mg ondansetron and 12.5 mg dolasetron for preventing postoperative nausea and vomiting (PONV) in patients undergoing gynecological procedures. The study found no statistically significant difference in the effectiveness of these two antiemetics.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Granisetron vs dolasetron for acute chemotherapy-induced nausea and vomiting (CINV) in high and moderately high emetogenic chemotherapy: an open-label pilot study.

Author: TanMarianne, XuRichard, SethRahul

Chemotherapy-induced nausea and vomiting prophylaxis

Granisetron and dolasetron, both oral serotonin type 3 receptor antagonists, were compared for their effectiveness in preventing acute chemotherapy-induced nausea and vomiting.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

[Prophylaxis of nausea and vomiting after pelviscopy. Dolasetron or MCP in comparison with placebo].

Author: RüschD, BernhardtJ, WulfH

Reduces PONV
PONV

Dolasetron and metoclopramide were effective in reducing postoperative nausea (PON) and postoperative vomiting (POV) after gynaecological laparoscopic surgery under balanced anesthesia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

18.

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.

Author: WeibelStephanie, RückerGerta, EberhartLeopold Hj, PaceNathan L, HartlHannah M, JordanOlivia L, MayerDebora, RiemerManuel, SchaeferMaximilian S, RajDiana, BackhausInsa, HelfAntonia, SchlesingerTobias, KienbaumPeter, KrankePeter

Reduced PONV

Postoperative nausea and vomiting (PONV) is a common adverse effect of anesthesia and surgery affecting up to 80% of patients. While various antiemetic drugs are available, further research is needed to determine the most effective drugs with the fewest side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Drugs for preventing postoperative nausea and vomiting.

Author: CarlisleJ B, StevensonC A

Reduced nausea
Reduced vomiting
Headache
Sedation

Eight drugs were found to be effective in preventing postoperative nausea and vomiting, but evidence for differences among them was unreliable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Comparison of perioperative oral multimodal analgesia versus IV PCA for spine surgery.

Author: RajpalSharad, GordonDebra B, PellinoTeresa A, StrayerAndrea L, BrostDenise, TrostGregory R, ZdeblickThomas A, ResnickDaniel K

Less drowsiness
Less interference with coughing and deep breathing
Less interference with walking
Less nausea
Less pain
Reduced opioid consumption

This study compared the effectiveness of a perioperative oral multimodal analgesia regimen with intravenous patient-controlled analgesia (IV PCA) in 100 patients undergoing spine surgery. Patients who received the oral regimen had significantly less opioid consumption, lower pain scores, and fewer side effects compared to those who received IV PCA.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

NMDA receptor complex antagonists have potential anxiolytic effects as measured with separation-induced ultrasonic vocalizations.

Author: KehneJ H, McCloskeyT C, BaronB M, ChiE M, HarrisonB L, WhittenJ P, PalfreymanM G

Anxiolytic effect
Muscle relaxant effect
Muscle relaxation

This study investigated the effects of various drugs on separation-induced vocalizations (SIV) in rat pups. NMDA antagonists, including those acting at the glutamate recognition site and the ion channel, suppressed SIV, while the glycine antagonist did not. This suggests that NMDA antagonists may have anxiolytic properties.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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