Side Effects of human papillomavirus (hpv) vaccine (cervarix): A Synthesis of Findings from 17 Studies

  1. Home
  2. Side Effects of human papillomavirus (hpv) vaccine (cervarix)
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of human papillomavirus (hpv) vaccine (cervarix): A Synthesis of Findings from 17 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of human papillomavirus (hpv) vaccine (cervarix): A Synthesis of Findings from 17 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Findings

Human papillomavirus (HPV) vaccines have been shown to be effective in preventing cervical cancer and other HPV-related diseases. However, there are concerns about side effects from vaccination. Several studies have investigated the safety and side effects of HPV vaccines. , 3 , 15 , 11 , 9 , 2 These studies have shown that HPV vaccines are generally safe and well-tolerated, but some side effects have been reported.

Reasons for Side Effects

HPV vaccines are made with virus-like particles (VLPs), which are proteins that resemble the HPV virus. VLPs stimulate the immune system to produce antibodies against HPV, but they are not actual viruses and cannot cause infection. However, VLPs can cause inflammation at the injection site. This inflammation is thought to be the cause of side effects from HPV vaccines.

Common Side Effects

Injection Site Reactions

The most common side effect is pain, swelling, and redness at the injection site. , 3 , 15 , 11 These symptoms usually disappear within a few days to a few weeks.

Systemic Symptoms

In addition to injection site reactions, fatigue, headache, fever, muscle aches, joint pain, and gastrointestinal symptoms have been reported. , 3 , 15 , 11 These symptoms are usually mild and disappear within a few days to a few weeks.

Side Effect Management

Injection Site Reactions

Symptoms such as pain, swelling, and redness at the injection site usually improve with rest and cold compresses. If symptoms are severe, consult a doctor.

Systemic Symptoms

Symptoms such as fatigue, headache, and fever usually improve with rest and adequate hydration. If symptoms are severe, consult a doctor.

Comparison Between Studies

Similarities in Studies

Multiple studies have shown that HPV vaccines are safe and well-tolerated. In addition, common side effects such as injection site reactions, fatigue, and headache have been reported.

Differences in Studies

The types and frequency of side effects reported vary between studies. This may be due to factors such as study design, age and health status of participants, and the vaccines used.

Considerations for Real-Life Applications

The safety and efficacy of HPV vaccines have been confirmed in numerous studies. However, the effects and side effects of vaccination can vary from person to person. Therefore, it is important to consult a doctor before receiving the HPV vaccine to make an informed decision based on your individual circumstances. Additionally, if you experience any unusual symptoms after vaccination, consult a doctor immediately.

Limitations of Current Research

Research on the safety and efficacy of HPV vaccines is still ongoing. More research is needed on long-term effects and rare side effects.

Future Research Directions

Research is needed on the long-term safety and efficacy of HPV vaccines, as well as rare side effects. In addition, research is needed to improve the efficacy of HPV vaccines.

Conclusion

The HPV vaccine is an effective tool for preventing cervical cancer and other HPV-related diseases. Many studies have shown that the HPV vaccine is safe and well-tolerated. However, as with all vaccines, there is a risk of side effects from the HPV vaccine. When considering vaccination, consult a doctor to make an informed decision based on your individual circumstances.

Literature analysis of 17 papers
Positive Content
16
Neutral Content
0
Negative Content
1
Article Type
4
1
1
3
17
1.

Combined bivalent human papillomavirus vaccine and Candida antigen versus Candida antigen alone in the treatment of recalcitrant warts.

Author: MareiAyman, NofalAhmad, AlakadRania, Abdel-HadyAmina

Safe treatment
Wart clearance

A combination therapy of bivalent HPV vaccine (Cervarix) and Candida antigen was more effective in treating multiple recalcitrant warts compared to Candida antigen alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

2.

Safety and Immunogenicity of the HPV-16/18 AS04-adjuvanted Vaccine in 4-6-year-old Girls: Results to Month 12 From a Randomized Trial.

Author: LinLan, ParraMercedes Macias, SierraVictor Y, CespedesAlbino Salas, GranadosMaria Angelica, LuqueAdriana, DamasoSilvia, Castrejon AlbaMaria Mercedes, Romano-MazzottiLuis, StruyfFrank

Cervical cancer prevention
HPV antibody production
Injection site pain

The HPV vaccine was well-tolerated and induced adequate antibody responses in 4-6-year-old girls.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Reactogenicity of Cervarix and Gardasil human papillomavirus (HPV) vaccines in a randomized single blind trial in healthy UK adolescent females.

Author: Haskins-CoulterTao, SouthernJo, AndrewsNick, MillerElizabeth

Gardasil immunogenicity
HPV vaccine safety
Cervarix swelling
Injection site tenderness

Gardasil® showed an acceptable safety profile compared to Cervarix® in a randomized trial of adolescent females.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

The safety of human papilloma virus-blockers and the risk of triggering autoimmune diseases.

Author: BakerBritain, Eça GuimarãesLuísa, TomljenovicLucija, Agmon-LevinNancy, ShoenfeldYehuda

HPV infection prevention
Aluminum adjuvant effects

This article aims to assess the risks and benefits of commercially available human papillomavirus vaccines (HPVv), addressing concerns about their safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

First generation prophylactic HPV vaccines: the state of the art.

Author: FruscalzoA, LonderoA, BertozziS, LelléR

HPV-related pathologies prevention

HPV vaccination is an effective way to prevent HPV-related pathologies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Long-term immunogenicity and safety of the HPV-16/18 AS04-adjuvanted vaccine in 10- to 14-year-old girls: open 6-year follow-up of an initial observer-blinded, randomized trial.

Author: SchwarzTino F, HuangLi-Min, LinTzou-Yien, WittermannChristoph, PanzerFalko, ValenciaAlejandra, SuryakiranPemmaraju V, LinLan, DescampsDominique

Clinically acceptable safety
High antibody levels
Long-term immunogenicity

The HPV-16/18 AS04-adjuvanted vaccine induced high anti-HPV-16 and -18 antibody levels up to 6 years postvaccination, predicted to remain above levels induced by natural infection for at least 20 years. The vaccine's safety profile was clinically acceptable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Safety, tolerability and side effects of human papillomavirus vaccines: a systematic quantitative review.

Author: GonçalvesAna Katherine, CobucciRicardo Ney, RodriguesHugo Marcus, de MeloAmanda Gosson, GiraldoPaulo César

HPV prevention
Fatigue
Fever
Gastrointestinal symptoms
Headache
Pain
Redness
Swelling

This systematic review of HPV vaccines found that they are generally safe and well-tolerated, with the most common side effects being pain, swelling, and redness at the injection site.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Human papilloma virus vaccine associated uveitis.

Author: HoltHenry D, HinkleDavid M, FalkNaomi S, FraunfelderFrederick T, FraunfelderFrederick W

Bilateral uveitis
Papillitis

A possible association between human papilloma virus (HPV) vaccination and uveitis has been reported. The median time from HPV vaccination to uveitis onset was 30 days. Clinicians should be aware of this possible side effect.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Safety and immunogenicity of the HPV-16/18 AS04-adjuvanted vaccine in HIV-positive women in South Africa: a partially-blind randomised placebo-controlled study.

Author: DennyLynette, HendricksBronwyn, GordonChivaugn, ThomasFlorence, HezarehMarjan, DobbelaereKurt, DurandChristelle, HervéCaroline, DescampsDominique

HPV vaccine efficacy
HPV vaccine safety

The HPV-16/18 AS04-adjuvanted vaccine was immunogenic and well-tolerated in women with HIV infection in a study conducted in South Africa. All vaccinated women were seropositive for both HPV-16 and HPV-18 after the second vaccine dose and remained seropositive at month 12. The vaccine induced sustained anti-HPV-16/18 CD4⁺ T-cell responses in both HIV-positive and HIV-negative women. CD4⁺ T-cell count, HIV viral load, and HIV clinical stage were unaffected by HPV-16/18 vaccine administration.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Safety and tolerability of bivalent HPV vaccine: an Italian post-licensure study.

Author: GaspariniRoberto, BonanniPaolo, LeviMiriam, BechiniAngela, BoccaliniSara, TiscioneEmilia, AmiciziaDaniela, LaiPiero Luigi, SulajKlodiana, PatriaAntonio Giuseppe, PanattoDonatella

Cervical cancer prevention
Fatigue
Headache
Pain

This study evaluated the safety and tolerability of the bivalent HPV vaccine Cervarix in Italy. No serious adverse events were observed. The most common side effects were pain at the injection site, fatigue, headache, and myalgia, all of which were generally mild and short-lived.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Evaluating societal preferences for human papillomavirus vaccine and cervical smear test screening programme.

Author: OtengBridgette, MarraFawziah, LyndLarry D, OgilvieGina, PatrickDavid, MarraCarlo A

Cervical cancer prevention
HPV prevention

The study found that the quadrivalent HPV vaccine (Gardasil) and the bivalent HPV vaccine (Cervarix) are both well-received by the public. Gardasil prevents genital warts and cervical cancer, while Cervarix only prevents cervical cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

A qualitative study to assess school nurses' views on vaccinating 12-13 year old school girls against human papillomavirus without parental consent.

Author: StretchRebecca, McCannRosemary, RobertsStephen A, EltonPeter, BaxterDavid, BrabinLoretta

HPV vaccination

This study explores the views of school nurses on vaccinating girls against HPV without parental consent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Safety of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine for cervical cancer prevention: a pooled analysis of 11 clinical trials.

Author: DescampsDominique, HardtKarin, SpiessensBart, IzurietaPatricia, VerstraetenThomas, BreuerThomas, DubinGary

Cervical cancer prevention

A pooled analysis of safety data from almost 30,000 girls and women aged 10 years and older who received the HPV-16/18 AS04-adjuvanted cervical cancer vaccine Cervarix showed that the vaccine had a favorable safety profile across all age groups (10-14, 15-25, and >25 years). While solicited local and general symptoms were more frequent in the vaccine group compared to controls, compliance with the three-dose schedule was high and did not differ between groups. There were no clinically relevant differences between the vaccine and control groups in rates of serious adverse events (2.8% vs. 3.1%), medically significant conditions (19.4% vs. 21.4%), new onset of chronic diseases (1.7% in both groups), or new onset of autoimmune diseases (0.4% vs. 0.3%). Similarly, no differences were observed in pregnancy outcomes or withdrawal rates due to adverse events or serious adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Cervical cancer prevention in the era of prophylactic vaccines: a preview for gynecologic oncologists.

Author: , CollinsYvonne, EinsteinMark H, GostoutBobbie S, HerzogThomas J, MassadL Stewart, RaderJanet S, WrightJason

Cervical cancer prevention

This article provides a comprehensive background on modern cervical cancer prevention strategies, including the quadrivalent and bivalent HPV vaccines, cervical cancer screening, and treatment of premalignant lesions. The article highlights the importance of continuing these practices for both vaccinated and unvaccinated women. The article also reviews the safety and side effects of the vaccines and explores future challenges in cervical cancer prevention.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.