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A comparison of the effects of oral nadolol and topical timolol on intraocular pressure, blood pressure, and heart rate.

Author: DuffG R, GrahamP A, WattA H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Nadolol and timolol, both eye pressure-lowering medications, were compared in a study of glaucoma suspects. Both drugs reduced eye pressure effectively, but nadolol caused a greater reduction in heart rate than timolol. Nadolol may be a useful alternative for treating glaucoma.
Paper Details　
Original Abstract of the Article :
We compared the effects of oral nadolol 20 mg once daily and topical timolol 0.25% twice daily on the intraocular pressures of 22 glaucoma suspects, in a 12 week double-masked crossover study. Both nadolol and timolol reduced intraocular pressure (p less than 0.001). The reductions in intraocular pr...See full text at original site
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引用元：
https://doi.org/10.1136/bjo.71.9.698

データ提供：米国国立医学図書館（NLM）

Comparing the Effects of Oral and Topical Medications for Glaucoma

The delicate balance of the eye is a constant source of fascination in the desert of ophthalmology. Glaucoma, a condition that can lead to vision loss, requires careful management of intraocular pressure (IOP). This research explores two different approaches to IOP control: oral nadolol and topical timolol, comparing their effectiveness and potential side effects.

Oral vs. Topical Medications for Glaucoma

This study compared the effects of oral nadolol and topical timolol on IOP, blood pressure, and heart rate in glaucoma suspects. The study found that both treatments effectively reduced IOP, but nadolol caused a significantly greater reduction in heart rate than timolol. This finding suggests that oral nadolol may be a viable alternative treatment for glaucoma, particularly for patients who may be sensitive to the potential cardiovascular side effects of topical beta-blockers.

Navigating the Trade-Offs of Treatment Options

This research highlights the importance of carefully considering the potential benefits and risks of different treatment options for glaucoma. The study's findings underscore the need for personalized care, taking into account individual patient factors such as cardiovascular health and medication preferences. This research emphasizes the importance of a collaborative approach between patient and physician in navigating the complex terrain of glaucoma management.

Dr. Camel's Conclusion

This research delves into the intricate world of glaucoma management, comparing the effectiveness of oral and topical medications for controlling intraocular pressure. The study's findings offer valuable insights into the potential benefits and risks of different treatment options, highlighting the importance of personalized care and careful consideration of individual patient factors. This research encourages a thoughtful approach to glaucoma management, navigating the delicate desert of ophthalmology with precision and sensitivity.

Date :
  1. Date Completed 1987-12-17
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

3663564

DOI: Digital Object Identifier

10.1136/bjo.71.9.698

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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