Effects of nebivolol and valsartan: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Nebivolol, a cardioselective beta-blocker with vasodilating effects, has shown effectiveness in treating essential hypertension. 5 It has been demonstrated to lower blood pressure in a dose-dependent manner, with a single daily dose of 5 mg being sufficient for most individuals. 5 Nebivolol's effectiveness was consistent across different ethnicities, with no significant difference in efficacy observed between black and non-black patients. 5 Furthermore, nebivolol was well-tolerated by patients, even at higher doses, and it achieved blood pressure control with minimal side effects commonly associated with beta-blockers. 5 Nebivolol's vasodilating effect contributes to its overall cardiovascular benefits. 4 However, a preliminary study suggested that nebivolol, similar to other beta-blockers, may impair psychomotor performance. 11 While nebivolol has been shown to be effective in treating heart failure, its beta-blocking effects have not been directly compared to other beta-blockers such as bisoprolol or carvedilol. 10 A comprehensive review suggests that nebivolol is generally well-tolerated by patients with asthma or COPD, and its fixed-dose combinations with other antihypertensive drugs could be beneficial for patients who cannot tolerate traditional beta-blockers. 13

Benefits and Risks

Benefit Summary

Nebivolol is an effective and well-tolerated antihypertensive medication. It lowers blood pressure effectively, has a favorable side effect profile compared to other beta-blockers, and has the potential to improve cardiovascular health due to its vasodilating effect. Nebivolol is a good option for patients who need a beta-blocker for their heart condition but cannot tolerate other traditional beta-blockers, particularly for those with asthma or COPD. 13 It may also be a suitable choice for patients who have a good response to beta-blockers and have minimal side effects.

Risk Summary

Nebivolol may impair psychomotor performance. 11 While it is generally well-tolerated by patients with asthma or COPD, it is still important to consult with a doctor before taking this medication if you have these conditions. 13 Further research is needed to fully assess the long-term safety and effectiveness of nebivolol. 12

Comparison Across Studies

Commonalities Across Studies

Multiple studies consistently demonstrate the effectiveness of nebivolol in lowering blood pressure and its favorable side effect profile compared to other beta-blockers. 5 9 7 8 3 Nebivolol's vasodilating properties are consistently highlighted as a beneficial aspect of this medication. 4 12 2

Differences Across Studies

There is some inconsistency in the findings regarding nebivolol's potential impact on psychomotor performance. One study found that nebivolol, similar to other beta-blockers, may impair psychomotor performance. 11 However, other studies did not report any significant effects on psychomotor function. 5 7 8 3 1 12 2 9 Further research is needed to clarify this discrepancy.

Consistency and Contradictions

The majority of studies consistently demonstrate that nebivolol is an effective and well-tolerated antihypertensive medication. 5 7 8 3 1 12 2 9 However, there is some inconsistency regarding its potential impact on psychomotor performance, which requires further investigation. 11

Real-Life Application Considerations

Nebivolol can be a safe and effective treatment option for hypertension. 5 12 However, if you experience any potential side effects, it is important to consult with your doctor. 11 13 If you have asthma or COPD, it is crucial to discuss with your doctor before taking nebivolol. 13 Remember, this information should not replace the advice of a qualified healthcare professional. Always discuss your individual needs with your doctor.

Limitations of Current Research

The long-term safety and effectiveness of nebivolol require further investigation. 12 More research is needed to clarify the discrepancy in findings regarding its effect on psychomotor performance. 11 Additionally, further research is necessary to understand the potential impact of nebivolol on asthma and COPD patients. 13

Future Research Directions

Long-term studies are needed to assess the long-term safety and effectiveness of nebivolol. 12 Additional research is crucial to resolve the inconsistency in findings regarding its effect on psychomotor performance. 11 Investigating the impact of nebivolol on asthma and COPD patients is another important area for future research. 13 Furthermore, examining the efficacy and safety of nebivolol in combination with other antihypertensive medications is a promising area for further exploration. 13

Conclusion

Nebivolol is a potentially valuable treatment option for hypertension, offering effective blood pressure control with a favorable side effect profile compared to other beta-blockers. It has been shown to be effective across various ethnicities, and it may be particularly beneficial for patients who cannot tolerate traditional beta-blockers due to asthma or COPD. However, it is essential to discuss with your doctor before taking nebivolol, especially if you have asthma or COPD, as it may impair psychomotor performance. More research is needed to fully assess its long-term effects and to clarify its impact on psychomotor performance and patients with asthma or COPD. Always consult with your doctor before making any decisions about your medication.

Literature analysis of 13 papers
Positive Content
12
Neutral Content
0
Negative Content
1
Article Type
12
0
1
0
13
1.

Comparison of the subacute hemodynamic effects of atenolol, propranolol, pindolol, and nebivolol.

Author: De CréeJ, CoboC, GeukensH, VerhaegenH

Effective beta-blocker
Improves left ventricular compliance

Nebivolol, a beta 1-selective adrenergic antagonist, improved left ventricular compliance, potentially by combined effects on preload and afterload.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Nebivolol in hypertension: a double-blind placebo-controlled multicenter study assessing its antihypertensive efficacy and impact on quality of life.

Author: Van BortelL M, BreedJ G, JoostenJ, KragtenJ A, LustermansF A, MooijJ M

Blood pressure control
Improved quality of life

Nebivolol, a selective beta 1-adrenoceptor antagonist, effectively lowered blood pressure without affecting quality of life perception. It had a favorable safety profile and no evidence of central nervous system side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Comparison of antihypertensive and beta 1-adrenoceptor antagonist effect of nebivolol and atenolol in essential hypertension.

Author: SimonG, JohnsonM L

Lower blood pressure
Reduced heart rate

Nebivolol is a new beta 1-adrenoceptor antagonist that is ten times more potent than atenolol at lowering blood pressure. In a study of 25 men with essential hypertension, nebivolol and atenolol were equally effective in reducing blood pressure and heart rate at rest and during exercise. Nebivolol is an effective antihypertensive agent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Haemodynamic effects and pharmacokinetics of oral d- and l-nebivolol in hypertensive patients.

Author: HimmelmannA, HednerT, SnoeckE, LundgrenB, HednerJ

Lowered blood pressure
Lowered heart rate

Oral nebivolol 5 mg once daily lowered blood pressure and heart rate during steady state compared to placebo. Venous volume was reduced during acute but not steady-state dosing, while peripheral resistance was unaffected in the acute phase but reduced during steady state.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A dose-response trial of nebivolol in essential hypertension.

Author: Van NuetenL, DupontA G, VertommenC, GoyvaertsH, RobertsonJ I

Effective BP reduction
Well-tolerated

Nebivolol, a cardioselective beta-blocker with nitric oxide-mediated vasodilation, effectively reduced blood pressure in a dose-dependent manner. It was well-tolerated with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Nebivolol: comparison of the effects of dl-nebivolol, d-nebivolol, l-nebivolol, atenolol, and placebo on exercise-induced increases in heart rate and systolic blood pressure.

Author: Van NuetenL, De CréeJ

Superior trough-to-peak efficacy ratio

Nebivolol, a beta-blocker, was found to be more effective than atenolol in inhibiting exercise-induced tachycardia. The beta-blocking effects of nebivolol reside in the d-isomer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Nebivolol versus nifedipine in the treatment of essential hypertension: a double-blind, randomized, comparative trial.

Author: Van NuetenL, LacourcièreY, VyssoulisG, KorliparaK, MarcadetD M, DupontA G, RobertsonJ I

Improved blood flow
Lowered blood pressure
Edema
Flushing
Headache

This double-blind, randomized trial found that nebivolol was significantly more effective than nifedipine in lowering blood pressure in patients with essential hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.

Author: Van NuetenL, Rishøj NielsenM, VertommenC, DupontA G, RobertsonJ I

Lowers blood pressure
Well-tolerated

Nebivolol and enalapril had very similar sustained effects in lowering both systolic and diastolic pressures. Both drugs were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Efficacy and tolerability profile of nebivolol vs atenolol in mild-to-moderate essential hypertension: results of a double-blind randomized multicentre trial.

Author: GrassiGuido, TrevanoFosca Quarti, FacchiniAnnalisa, ToutouzasTorakis, ChanuBernard, ManciaGiuseppe

Antihypertensive effect
Better tolerability
Lower side-effect incidence

Nebivolol (5 mg daily) and atenolol (100 mg daily) showed similar antihypertensive effects in a 12-week double-blind randomized study of mild-to-moderate hypertensives. Nebivolol had a better tolerability profile and a lower incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

Author: StoschitzkyKurt, StoschitzkyGergana, BrusseeHelmut, BonelliClaudia, DobnigHarald

Improved QOL
Reduced heart rate
Sleep disturbances

Bisoprolol, carvedilol, and nebivolol all effectively reduce heart rate, but they have distinct effects on peak and trough beta-blocking activity and nocturnal melatonin release. Bisoprolol exhibits stronger peak beta-blocking effects, while nebivolol has the highest trough-to-peak ratio. Only bisoprolol significantly reduced nocturnal melatonin release, potentially leading to sleep disturbances.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Comparative effects of conventional B-blockers and nebivolol on psychomotor performances in healthy volunteers: a preliminary report.

Author: KumarA, KhajuriaV, TandonVishal R, KapoorB, SinghR

Psychomotor impairment

This study compared the effects of nebivolol, propranolol, and atenolol on psychomotor performance in healthy volunteers. Single doses of atenolol and propranolol significantly impaired psychomotor performance, and nebivolol had similar effects, likely due to its lipophilic nature.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Comparison of Nebivolol monotherapy versus Nebivolol in combination with other antihypertensive therapies for the treatment of hypertension.

Author: PapademetriouVasilios

Blood pressure control
Hypertension treatment

Nebivolol is a beta1-adrenergic receptor blocker with vasodilatory properties. This long-term study demonstrated that nebivolol is safe and effective for treating hypertension, providing long-term blood pressure lowering effects with favorable tolerability.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

A Critical Review of Nebivolol and its Fixed-Dose Combinations in the Treatment of Hypertension.

Author: CiceroArrigo F G, KuwabaraMasanari, BorghiClaudio

Arterial stiffness reduction
Endothelial dysfunction improvement
Hypertension treatment
Asthma
COPD
Glucose metabolism
Lipid metabolism

Nebivolol, a β-1 receptor-selective blocker with nitric oxide-mediated vasodilatory effects, is well tolerated by patients with asthma or COPD and has a favorable metabolic profile. Nebivolol is effective in reducing blood pressure and improving endothelial dysfunction and arterial stiffness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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