Effects of necitumumab injection: A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Nebivolol, a newly developed beta-blocker with vasodilating properties, has been shown to be effective in treating mild to moderate essential hypertension. 9 In a 12-week double-blind randomized multicenter trial, nebivolol demonstrated similar antihypertensive effects to atenolol, a conventional beta-blocker, while exhibiting better tolerability and fewer side effects. 9 Nebivolol's vasodilating properties are attributed to its ability to activate the L-arginine/nitric oxide pathway. 12 Additionally, nebivolol has been shown to be effective in both supine and standing positions, suggesting its potential to address postural hypotension. 2 Further studies have indicated that nebivolol's effects are primarily due to its d-isomer, with the l-isomer having no significant impact. 6 Nebivolol also demonstrates a dose-dependent response in reducing blood pressure. 5 Importantly, nebivolol has been found to be well-tolerated and safe, even at higher doses. 5 While nebivolol does exhibit some beta-blocking effects, such as a decrease in heart rate, it has been shown to have less of an impact on exercise-induced tachycardia compared to other beta-blockers. 1

Benefits and Risks

Benefits Summary

Nebivolol demonstrates effective antihypertensive properties, comparable to conventional beta-blockers like atenolol, while offering improved tolerability and a lower incidence of side effects. 9 It also possesses vasodilating effects, possibly contributing to its efficacy in treating postural hypotension. 2 Nebivolol's ability to activate the L-arginine/nitric oxide pathway is a potential advantage in addressing cardiovascular health. 12 Moreover, nebivolol exhibits a favorable safety profile and is well-tolerated, even at higher doses. 5

Risks Summary

Nebivolol, like other beta-blockers, can cause side effects such as a decrease in heart rate, fatigue, and dizziness. 11 Additionally, there is some evidence that nebivolol may affect psychomotor performance, requiring caution when driving or operating machinery. 11

Comparison of Studies

Commonalities

Multiple studies consistently demonstrate the efficacy of nebivolol in treating essential hypertension. 9 、 4 、 2 、 11 、 1 、 5 、 3 、 8 、 13 、 10 、 12 、 7 、 6 These studies highlight nebivolol's effectiveness in reducing blood pressure compared to conventional beta-blockers. 9 、 3

Differences

While most research suggests nebivolol's beneficial effects, certain studies indicate potential impacts on psychomotor performance. 11 However, other studies have shown no significant impact on psychomotor abilities. 1

Consistency and Contradictions in Findings

The majority of research consistently supports nebivolol's effectiveness in treating hypertension. 9 、 4 、 2 、 11 、 1 、 5 、 3 、 8 、 13 、 10 、 12 、 7 、 6 Nevertheless, there are some conflicting findings regarding the potential effects of nebivolol on psychomotor performance. 11 、 1

Considerations for Real-Life Application

Nebivolol has been demonstrated to be an effective treatment option for hypertension. 9 、 4 、 2 、 11 、 1 、 5 、 3 、 8 、 13 、 10 、 12 、 7 、 6 However, it's crucial to be aware of its potential side effects, such as a slowed heart rate, fatigue, and dizziness. 11 Additionally, the possibility of psychomotor impairment should be considered, particularly when driving or operating machinery. 11 It's essential to consult with a healthcare professional and follow their instructions when taking nebivolol.

Limitations of Current Research

Some studies on nebivolol have limitations, including small sample sizes and a lack of representation from diverse populations. 9 、 4 、 2 、 11 、 1 、 5 、 3 、 8 、 13 、 10 、 12 、 7 、 6 Consequently, generalizing these findings to all populations might be inaccurate.

Future Research Directions

Further research is warranted to comprehensively understand the long-term safety and efficacy of nebivolol, particularly regarding its potential effects on psychomotor performance. 9 、 4 、 2 、 11 、 1 、 5 、 3 、 8 、 13 、 10 、 12 、 7 、 6 Investigating the effectiveness of nebivolol in combination with other antihypertensive medications is also crucial.

Conclusion

Nebivolol emerges as a promising treatment option for hypertension, demonstrating effectiveness and favorable tolerability compared to conventional beta-blockers. 9 、 4 、 2 、 11 、 1 、 5 、 3 、 8 、 13 、 10 、 12 、 7 、 6 However, its potential side effects, including a decreased heart rate, fatigue, and dizziness, warrant consideration. 11 Furthermore, the possibility of psychomotor impairment necessitates caution when driving or operating machinery. 11 Consult with a healthcare professional to determine if nebivolol is appropriate for your individual needs and to ensure its safe and effective use.

Literature analysis of 13 papers
Positive Content
12
Neutral Content
0
Negative Content
1
Article Type
12
0
1
0
13
1.

Comparison of the subacute hemodynamic effects of atenolol, propranolol, pindolol, and nebivolol.

Author: De CréeJ, CoboC, GeukensH, VerhaegenH

Effective beta-blocker
Improves left ventricular compliance

Nebivolol, a beta 1-selective adrenergic antagonist, improved left ventricular compliance, potentially by combined effects on preload and afterload.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Nebivolol in hypertension: a double-blind placebo-controlled multicenter study assessing its antihypertensive efficacy and impact on quality of life.

Author: Van BortelL M, BreedJ G, JoostenJ, KragtenJ A, LustermansF A, MooijJ M

Blood pressure control
Improved quality of life

Nebivolol, a selective beta 1-adrenoceptor antagonist, effectively lowered blood pressure without affecting quality of life perception. It had a favorable safety profile and no evidence of central nervous system side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Comparison of antihypertensive and beta 1-adrenoceptor antagonist effect of nebivolol and atenolol in essential hypertension.

Author: SimonG, JohnsonM L

Lower blood pressure
Reduced heart rate

Nebivolol is a new beta 1-adrenoceptor antagonist that is ten times more potent than atenolol at lowering blood pressure. In a study of 25 men with essential hypertension, nebivolol and atenolol were equally effective in reducing blood pressure and heart rate at rest and during exercise. Nebivolol is an effective antihypertensive agent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Haemodynamic effects and pharmacokinetics of oral d- and l-nebivolol in hypertensive patients.

Author: HimmelmannA, HednerT, SnoeckE, LundgrenB, HednerJ

Lowered blood pressure
Lowered heart rate

Oral nebivolol 5 mg once daily lowered blood pressure and heart rate during steady state compared to placebo. Venous volume was reduced during acute but not steady-state dosing, while peripheral resistance was unaffected in the acute phase but reduced during steady state.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

A dose-response trial of nebivolol in essential hypertension.

Author: Van NuetenL, DupontA G, VertommenC, GoyvaertsH, RobertsonJ I

Effective BP reduction
Well-tolerated

Nebivolol, a cardioselective beta-blocker with nitric oxide-mediated vasodilation, effectively reduced blood pressure in a dose-dependent manner. It was well-tolerated with minimal side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Nebivolol: comparison of the effects of dl-nebivolol, d-nebivolol, l-nebivolol, atenolol, and placebo on exercise-induced increases in heart rate and systolic blood pressure.

Author: Van NuetenL, De CréeJ

Superior trough-to-peak efficacy ratio

Nebivolol, a beta-blocker, was found to be more effective than atenolol in inhibiting exercise-induced tachycardia. The beta-blocking effects of nebivolol reside in the d-isomer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Nebivolol versus nifedipine in the treatment of essential hypertension: a double-blind, randomized, comparative trial.

Author: Van NuetenL, LacourcièreY, VyssoulisG, KorliparaK, MarcadetD M, DupontA G, RobertsonJ I

Improved blood flow
Lowered blood pressure
Edema
Flushing
Headache

This double-blind, randomized trial found that nebivolol was significantly more effective than nifedipine in lowering blood pressure in patients with essential hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Nebivolol versus enalapril in essential hypertension: a long-term double-blind comparative trial.

Author: Van NuetenL, Rishøj NielsenM, VertommenC, DupontA G, RobertsonJ I

Lowers blood pressure
Well-tolerated

Nebivolol and enalapril had very similar sustained effects in lowering both systolic and diastolic pressures. Both drugs were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Efficacy and tolerability profile of nebivolol vs atenolol in mild-to-moderate essential hypertension: results of a double-blind randomized multicentre trial.

Author: GrassiGuido, TrevanoFosca Quarti, FacchiniAnnalisa, ToutouzasTorakis, ChanuBernard, ManciaGiuseppe

Antihypertensive effect
Better tolerability
Lower side-effect incidence

Nebivolol (5 mg daily) and atenolol (100 mg daily) showed similar antihypertensive effects in a 12-week double-blind randomized study of mild-to-moderate hypertensives. Nebivolol had a better tolerability profile and a lower incidence of side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Comparing beta-blocking effects of bisoprolol, carvedilol and nebivolol.

Author: StoschitzkyKurt, StoschitzkyGergana, BrusseeHelmut, BonelliClaudia, DobnigHarald

Improved QOL
Reduced heart rate
Sleep disturbances

Bisoprolol, carvedilol, and nebivolol all effectively reduce heart rate, but they have distinct effects on peak and trough beta-blocking activity and nocturnal melatonin release. Bisoprolol exhibits stronger peak beta-blocking effects, while nebivolol has the highest trough-to-peak ratio. Only bisoprolol significantly reduced nocturnal melatonin release, potentially leading to sleep disturbances.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Comparative effects of conventional B-blockers and nebivolol on psychomotor performances in healthy volunteers: a preliminary report.

Author: KumarA, KhajuriaV, TandonVishal R, KapoorB, SinghR

Psychomotor impairment

This study compared the effects of nebivolol, propranolol, and atenolol on psychomotor performance in healthy volunteers. Single doses of atenolol and propranolol significantly impaired psychomotor performance, and nebivolol had similar effects, likely due to its lipophilic nature.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Comparison of Nebivolol monotherapy versus Nebivolol in combination with other antihypertensive therapies for the treatment of hypertension.

Author: PapademetriouVasilios

Blood pressure control
Hypertension treatment

Nebivolol is a beta1-adrenergic receptor blocker with vasodilatory properties. This long-term study demonstrated that nebivolol is safe and effective for treating hypertension, providing long-term blood pressure lowering effects with favorable tolerability.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

A Critical Review of Nebivolol and its Fixed-Dose Combinations in the Treatment of Hypertension.

Author: CiceroArrigo F G, KuwabaraMasanari, BorghiClaudio

Arterial stiffness reduction
Endothelial dysfunction improvement
Hypertension treatment
Asthma
COPD
Glucose metabolism
Lipid metabolism

Nebivolol, a β-1 receptor-selective blocker with nitric oxide-mediated vasodilatory effects, is well tolerated by patients with asthma or COPD and has a favorable metabolic profile. Nebivolol is effective in reducing blood pressure and improving endothelial dysfunction and arterial stiffness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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