Effective treatment of scars: A Synthesis of Findings from 65 Studies

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Original Abstract of the Article

Major research findings

Several studies have been conducted to explore effective treatments for different types of scars. For instance, 35 investigated the effects of fractional CO2 laser treatment on cesarean section scars, demonstrating improvement in scar appearance after 6 months. Additionally, 33 compared the effectiveness of nonablative fractional erbium laser 1,340 nm and microneedling for treating atrophic acne scars, finding both treatments to be effective.

compared intralesional verapamil and intralesional corticosteroids for keloids and hypertrophic scars, concluding that corticosteroids were more effective. Furthermore, 37 reported the effectiveness of skin distractors in scar treatment, particularly for extremities, with a pull speed of 2 mm/d showing better results.

57 highlighted the effectiveness of silicone gel sheeting for treating hypertrophic scars, and 28 added that silicone gel sheeting can be useful for both preventing and treating hypertrophic scars and keloids.

56 suggested the use of corticosteroids alone or in combination with botulinum toxin type A for treating keloids and hypertrophic scars. Additionally, 26 compared the effectiveness of non-ablative 1550-nm fractional Er: glass laser and ablative 2940-nm fractional Er: YAG laser for thyroidectomy scar prevention, finding both effective in improving scar appearance.

38 compared microneedling and autologous platelet-rich plasma (PRP) for treating atrophic scars, concluding that a combination of both treatments was most effective. Furthermore, 62 compared the effectiveness of PRP in liquid or gel form combined with fractional CO2 laser for treating atrophic acne scars, demonstrating that PRP gel showed better results.

Treatment summary

Treatments for scars include laser therapy, microneedling, silicone gel sheeting, intralesional corticosteroids, and PRP. Each treatment utilizes a different mechanism to improve scar appearance. Laser therapy aims to improve scars by using heat to destroy scar tissue and promote new tissue growth. Microneedling involves creating tiny punctures in the skin to stimulate collagen production and enhance scar appearance. Silicone gel sheeting applies pressure to the scar, reducing collagen production and improving scar appearance. Intralesional corticosteroids aim to improve scars by reducing inflammation and inhibiting collagen production. PRP is rich in growth factors that promote scar healing and can contribute to scar improvement.

Benefits and Risks

Benefit summary

Scar treatment can offer numerous benefits, including improved scar appearance and function, pain and itch relief, and reduced psychological distress. Additionally, treatments can help prevent scar recurrence.

Risk summary

Scar treatment involves certain risks, including pain, swelling, redness, pigmentation changes, infection, and potential worsening of the scar.

Comparison of studies

Commonalities between studies

Many studies have demonstrated the effectiveness of treatments like laser therapy, microneedling, silicone gel sheeting, and intralesional corticosteroids in improving scar appearance.

Differences between studies

Studies vary in terms of scar type, treatment methods, evaluation techniques, and results. This can make direct comparison of results challenging.

Consistency and Contradictions in Results

Although many studies have been conducted on scar treatment, consistent results across all studies are not always observed. Some studies highlight the effectiveness of specific treatments, while others find the same treatments less effective. This can be attributed to differences in the types of scars studied, treatment methods, evaluation techniques, and individual responses to treatment.

Points to note about applying research findings to real-life situations

The most effective treatment for scars depends on the specific type of scar and the individual's condition. It's essential to consult a doctor before beginning any treatment to ensure the most appropriate approach is chosen.

Limitations of Current Research

Despite extensive research on scar treatment, certain aspects remain unclear, necessitating further research. This includes exploring effective methods to prevent scar recurrence, as well as developing novel treatments.

Future Research Directions

Future research should focus on standardizing scar types, treatment methods, evaluation techniques, and outcomes to ensure more accurate and comparable results. Studies investigating long-term effects and side effects are also crucial.

Conclusion

The choice of treatment for scars depends on the individual scar type and the patient's condition. Consulting a doctor is essential to select the most effective treatment. Continuous research in scar treatment is ongoing, and the development of safer and more effective therapies is anticipated.

List of treatments

Laser therapy, microneedling, silicone gel sheeting, intralesional corticosteroids, PRP, skin distractor, UVA light exposure, dry tattooing, 5-fluorouracil, verapamil, tazarotene gel

Keywords
Benefit Keywords
Reduces scar pain
1
Scar improvement
2
Reduced hypertrophic scar bulk
Reduced symptoms
3
Scar improvement
4
Burn scar treatment
5
Atrophic scar treatment
6
Acne scar treatment
7
Improve scar appearance
8
Scar improvement
9
Improved scar management
10
Improved keloid and scar appearance
11
Improved keloid and hypertrophic scar treatment
12
Improves hypertrophic scars
Improves keloids
13
Acne scarring prevention
Acne scarring treatment
14
Effective scar treatment
Improved scar appearance
16
Improved keloid and scar symptoms
17
Improved scar appearance
18
Burn scar treatment
19
Acne scar treatment
Improved scar appearance
Reduced complications
20
Acne scar treatment
21
One-step procedure
Scar excision optimization
22
Treats hypertrophic scars
Treats keloids
23
Keloid treatment
24
Improved scar appearance
25
Improved scar appearance
26
Safe and effective treatment
27
Hypertrophic scarring treatment
28
Effective for acne scars
Safe for acne scars
29
Hypertrophic scar treatment
Keloid treatment
Scar prevention
30
scar improvement
31
Safe
Scar improvement
32
Improved acne scars
33
Improved scar pliability
New collagen and elastic fibers
Smoother scar surface
35
Scar treatment
36
Better effects on scar treatment
37
Fewer sessions
Improved scar appearance
38
Keloid treatment
40
Lower recurrence rate
Scar reduction
41
Acne scar improvement
Quantitative severity
42
Effective scar treatment
Improved scar appearance
43
Improved scar appearance
44
Hypertrophic scar treatment
Keloid treatment
45
Presurgical laser treatment
46
Improved facial scar treatment
47
Comparable to laser
Effective scar treatment
48
Reduced hematoma
Scar improvement
49
Scar treatment
50
Improved keloid and hypertrophic scar treatment
51
Improved scar appearance
52
Hypertrophic scar treatment
Keloid treatment
55
Intralesional corticosteroid injection for keloid and hypertrophic scars
56
Scar treatment
57
Scar prevention
58
Acne scar treatment
59
Improved arm contouring
Reduced skin laxity
60
Reduced scar height
Reduced scar pliability
61
Acne scar treatment
Improved skin appearance
62
Scar treatment
63
Scar treatment
64
Keloid treatment
65
Risk Keywords
High recurrence rates
Side effects
3
Edema
Erythema
7
Multiple treatments needed
Purpura
9
Hypertrophic scars
Keloid scars
10
Atrophy
Telangiectasia
11
None mentioned
12
None specified
18
None reported
20
Acneiform eruption
Hyperpigmentation
21
Skin stretching device risks
22
Pain during treatment
23
None
24
None
27
Erythema
PIH
33
Acne scarring common
Lack of high-quality evidence
Negative psychosocial impact
34
Transient erythema and hyperpigmentation
35
Surgical scar cosmesis
36
Ineffectiveness
40
Entry point burn
49
Skin atrophy
Telangiectasia
53
Hormonal imbalance
Irregular menstruation
Pain
54
Further research needed
Limited sample size
62
None reported
63
Literature analysis of 65 papers
Positive Content
61
Neutral Content
4
Negative Content
0
Article Type
50
11
10
10
65
1.

Insertion of intradermal needles into painful points provides analgesia for intractable abdominal scar pain.

Author: KotaniN, KushikataT, SuzukiA, HashimotoH, MuraokaM, MatsukiA

Reduces scar pain

Insertion of intradermal needles into painful points is a remarkably effective treatment for intractable abdominal scar pain.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Effect of four treatment variants on the functional and cosmetic state of mature scars.

Author: KloppR, NiemerW, FraenkelM, von der WethA

Scar improvement

A study comparing four different treatment modalities for older scars found that a combination of polyurethane dressing and compression or silicone sheeting and compression were most effective in improving scar tissue.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Laser scar revision: comparison study of 585-nm pulsed dye laser with and without intralesional corticosteroids.

Author: AlsterTina

Reduced hypertrophic scar bulk
Reduced symptoms
High recurrence rates
Side effects

Hypertrophic scars affect 1.5-4.5% of people and are difficult to treat due to high recurrence rates and side effects. Both pulsed dye laser (PDL) treatment and injections of corticosteroids have been shown to reduce the size and symptoms of hypertrophic scars.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

585-nm pulsed dye laser in the treatment of surgical scars starting on the suture removal day.

Author: NouriKeyvan, JimenezGloria P, Harrison-BalestraCatherine, ElgartGeorge W

Scar improvement

The 585-nm pulsed dye laser was effective and safe in improving the quality and cosmetic appearance of surgical scars.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Pulsed dye laser treatment of burn scars. Alleviation or irritation?

Author: AllisonK P, KiernanM N, WatersR A, ClementR M

Burn scar treatment

This study investigated the effectiveness of dye laser treatment for burn scars, specifically looking at its impact on redness, texture, and itchiness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Comparison of a 1450-nm diode laser and a 1320-nm Nd:YAG laser in the treatment of atrophic facial scars: a prospective clinical and histologic study.

Author: TanziElizabeth L, AlsterTina S

Atrophic scar treatment

While many techniques exist to improve the appearance of sunken scars, results are often limited and recovery is lengthy. Non-ablative lasers have shown promise in remodeling skin collagen with minimal side effects. While research has focused on wrinkles, there's limited data on their specific use for sunken scars.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Comparison of a 1,064 nm laser and a 1,320 nm laser for the nonablative treatment of acne scars.

Author: YaghmaiDina, GardenJerome M, BakusAbnoeal D, MassaMary C

Acne scar treatment
Edema
Erythema

Both the 1,064 nm and 1,320 nm Nd:YAG lasers were safe and effective for nonablative treatment of acne scars. The 1,064 nm laser showed greater clinical improvement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Treatment of surgical scars with the cryogen-cooled 595 nm pulsed dye laser starting on the day of suture removal.

Author: ConologueTheresa Dressler, NorwoodChristopher

Improve scar appearance

This study focuses on the optimal timing of laser treatment for scar improvement after skin surgery, suggesting that starting treatment immediately after suture removal may lead to better outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Clinical effect of a single pulsed dye laser treatment of fresh surgical scars: randomized controlled trial.

Author: AlamMurad, PonKucy, Van LabordeS, KaminerMichael S, ArndtKenneth A, DoverJeffrey S

Scar improvement
Multiple treatments needed
Purpura

A single pulsed dye laser treatment at the time of suture removal does not appear to have a beneficial effect on clinical scar appearance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Silicon gel sheeting for preventing and treating hypertrophic and keloid scars.

Author: O'BrienL, PanditA

Improved scar management
Hypertrophic scars
Keloid scars

Keloid and hypertrophic scars are common and can cause physical and emotional problems. While treating these scars can be challenging, using silicone gel sheets to prevent and treat raised scars is a newer approach that was first used in 1981 for burn scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars.

Author: AsilianAli, DaroughehAfshin, ShariatiFazlolah

Improved keloid and scar appearance
Atrophy
Telangiectasia

The combination of intralesional triamcinolone acetonide (TAC) and 5-fluorouracil (5-FU) with pulsed-dye laser (PDL) was more effective and acceptable than TAC alone or TAC+5-FU in the treatment of keloid and hypertrophic scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Bleomycin tattooing as a promising therapeutic modality in large keloids and hypertrophic scars.

Author: NaeiniFarahnaz Fatemi, NajafianJamshid, AhmadpourKoorosh

Improved keloid and hypertrophic scar treatment
None mentioned

Bleomycin tattoo may be more effective than cryotherapy combined with intralesional triamcinolone injection in the treatment of larger keloids and hypertrophic scars.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Treatment of keloids and hypertrophic scars: a meta-analysis and review of the literature.

Author: LeventhalDouglas, FurrMaxwell, ReiterDavid

Improves hypertrophic scars
Improves keloids

This study reviews treatment regimens for hypertrophic scars and keloids, finding limited evidence for substantial improvement with most available treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Combined 0.1% retinaldehyde/ 6% glycolic acid cream in prophylaxis and treatment of acne scarring.

Author: DrenoBrigitte, KatsambasAndreas, PelfiniCarlo, PlantierDaniel, JancoviciEliane, RibetVirginie, NoceraThérèse, MorinetPierre, KhammariAmir

Acne scarring prevention
Acne scarring treatment

A 0.1% retinaldehyde/6% glycolic acid (RALGA) cream was found to be effective in preventing and treating acne scarring in patients with moderate acne. In a double-blind vehicle-controlled study, patients using RALGA cream showed significant improvement in global scarring score, inflammatory lesions, and comedones after 28 days, compared to the vehicle group. After 3 months, the RALGA cream was significantly more efficient than the vehicle in reducing scarring due to erythema and hyperpigmentation improvement.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

[A comparative clinical study of the treatment of hypertrophic scars with either intralaesional steroid or silicone gel sheeting].

Author: KelemenOttó, KollárLajos, MenyheiGábor

The study compared the effectiveness of intralaesional steroid therapy and silicone gel sheeting for the treatment of linear hypertrophic scars, concluding that silicone gel sheeting is the first-line treatment and intralaesional steroid is the second-line treatment.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Hungarian

16.

An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids.

Author: KocErol, ArcaErcan, SurucuBaris, KurumluZafer

Effective scar treatment
Improved scar appearance

Intralesional triamcinolone acetonide combined with onion extract gel was more effective than triamcinolone acetonide alone in treating keloidal and hypertrophic scars. The combined treatment resulted in significant improvement in pain, itching, and elevation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars.

Author: DaroughehA, AsilianA, ShariatiF

Improved keloid and scar symptoms

A combination of triamcinolone acetonide (TAC) and 5-fluorouracil (5-FU) is more effective and acceptable to patients compared to TAC alone in treating keloids and hypertrophic scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

A pilot randomized control trial of scar repigmentation with UV light and dry tattooing.

Author: BrandtMichael G, MooreCorey C, ConlinAnne E, SteinJohn D, DoylePhilip C

Improved scar appearance
None specified

Dry-tattooing combined with UV light exposure was effective in treating hypopigmented cervicofacial scars, improving scar appearance and increasing melanin content to match surrounding skin.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Fractional nonablative 1540 nm laser resurfacing for thermal burn scars: a randomized controlled trial.

Author: HaedersdalMerete, MoreauKaren E R, BeyerDitte M, NymannPeter, AlsbjørnBjarne

Burn scar treatment

This randomized trial evaluated the efficacy and adverse effects of 1540 nm fractional laser versus untreated control for burn scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Clinical trial of dual treatment with an ablative fractional laser and a nonablative laser for the treatment of acne scars in Asian patients.

Author: KimSangeun, ChoKyeong-Hun

Acne scar treatment
Improved scar appearance
Reduced complications
None reported

The combination of ablative fractional laser resurfacing and nonablative laser resurfacing yielded the best results for acne scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Treatment of punched-out atrophic and rolling acne scars in skin phototypes III, IV, and V with variable square pulse erbium:yttrium-aluminum-garnet laser resurfacing.

Author: WanitphakdeedechaRungsima, ManuskiattiWoraphong, SiriphukpongSujittra, ChenT Minsue

Acne scar treatment
Acneiform eruption
Hyperpigmentation

Low-fluence VSP Er:YAG laser resurfacing is a promising treatment option for acne scars, with minimal risk of side effects. Laser pulse width and energy determine the efficacy and the risk of side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Efficacy of skin stretching for burn scar excision: a multicenter randomized controlled trial.

Author: VerhaegenPauline D H M, van TrierAntoine J M, JongenSandra J M, VligMarcel, NieuwenhuisMarianne K, MiddelkoopEsther, van ZuijlenPaul P M

One-step procedure
Scar excision optimization
Skin stretching device risks

A randomized controlled trial is investigating a skin-stretching device for wound closure after burn scar excision, aiming to optimize use of healthy skin and potentially allow for scar excision in a single procedure.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Pain evaluation and control during and following the treatment of hypertrophic scars and keloids by contact and intralesional cryosurgery--a preliminary study.

Author: MirmovichO, GilT, GoldinI, LaviI, MettanesI, Har-ShaiY

Treats hypertrophic scars
Treats keloids
Pain during treatment

Intralesional cryosurgery caused the least pain during and immediately after treatment. The pain-control protocol significantly reduced pain severity to tolerable levels during and following intralesional and contact cryosurgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids.

Author: SadeghiniaAli, SadeghiniaSaeed

Keloid treatment
None

5-fluorouracil (5-FU) tattooing was found to be more effective than intralesional triamcinolone acetonide (TAC) in treating keloids. Both treatments showed improvement in erythema, pruritus, height, surface, and induration, but the 5-FU group demonstrated greater improvement. Both treatments were well tolerated with no side effects reported.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

25.

Treatment of traumatic scars using fat grafts mixed with platelet-rich plasma, and resurfacing of skin with the 1540 nm nonablative laser.

Author: CervelliV, NicoliF, SpalloneD, VerardiS, SorgeR, NicoliM, BalzaniA

Improved scar appearance

This study investigated the combined effects of fat grafts, laser treatment, and platelet-rich plasma (PRP) on traumatic scars, aiming to improve cosmetic and functional outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Comparison of the effectiveness of nonablative fractional laser versus ablative fractional laser in thyroidectomy scar prevention: A pilot study.

Author: KimHei Sung, LeeJi Hae, ParkYoung Min, LeeJun Young

Improved scar appearance

This pilot study examined the effects of non-ablative 1550-nm fractional Er: glass laser and ablative 2940-nm fractional Er: YAG laser on fresh surgical scars.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Randomized clinical trial of CO2 laser pinpoint irradiation technique with/without needling for ice pick acne scars.

Author: MohammedGhada

Safe and effective treatment
None

Pinpoint irradiation technique by CO2 laser without needling is safe and effective for treating ice pick acne scars. It is as effective as pinpoint irradiation technique with needling.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Silicone gel sheeting for preventing and treating hypertrophic and keloid scars.

Author: O'BrienLisa, JonesDaniel J

Hypertrophic scarring treatment

Keloids and hypertrophic scars are raised, thick scars that can be difficult to treat and cause physical and emotional distress. Silicone gel sheeting is a newer treatment approach that began with burn scars in 1981.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

29.

Randomized clinical trial of CO₂ LASER pinpoint irradiation technique versus chemical reconstruction of skin scars (CROSS) in treating ice pick acne scars.

Author: AhmedRadwa, MohammedGhada, IsmailNader, ElakhrasAtef

Effective for acne scars
Safe for acne scars

A study of 28 patients with ice pick acne scars found that pinpoint irradiation technique by CO₂ LASER was more effective than TCA CROSS technique in treating ice pick acne scars. Pinpoint irradiation technique by CO₂ LASER was also found to be safe.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

30.

Laser therapy for prevention and treatment of pathologic excessive scars.

Author: JinRui, HuangXiaolu, LiHua, YuanYuwen, LiBin, ChengChen, LiQingfeng

Hypertrophic scar treatment
Keloid treatment
Scar prevention

This meta-analysis evaluated the effectiveness of various laser therapies for the treatment of hypertrophic scars and keloids. The meta-analysis found that laser therapy was effective for scar prevention, hypertrophic scar treatment, and keloid treatment. The 585/595-nm pulsed-dye laser and 532-nm laser subgroups yielded the best responses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

31.

Treatment of surgical scars using a 595-nm pulsed dye laser using purpuric and nonpurpuric parameters: a comparative study.

Author: GladsjoJulie Akiko, JiangShang I Brian

scar improvement

This study found that using a pulsed dye laser (PDL) with non-purpuric settings resulted in significant improvements in the appearance of fresh surgical scars compared to purpuric settings or no treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: A comparative randomized split-scar trial.

Author: Al-MohamadyAbd El-Shakour Abd El-Hafiz, IbrahimShady Mahmoud Attia, MuhammadMuhammad Mohsen

Safe
Scar improvement

Pulsed dye laser (PDL) and Nd:YAG laser treatments for keloid and hypertrophic scar provide significant improvement with insignificant difference between both modalities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Comparison of Nonablative Fractional Erbium Laser 1,340 nm and Microneedling for the Treatment of Atrophic Acne Scars: A Randomized Clinical Trial.

Author: CachafeiroThaís, EscobarGabriela, MaldonadoGabriela, CestariTania, CorletaOly

Improved acne scars
Erythema
PIH

Both nonablative fractional laser 1,340 nm and microneedling are comparable and effective in the treatment of atrophic acne scars. Microneedling is well tolerated, with fewer side effects and lower down time.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Interventions for acne scars.

Author: Abdel HayRania, ShalabyKhalid, ZaherHesham, HafezVanessa, ChiChing-Chi, DimitriSandra, NabhanAshraf F, LaytonAlison M

Acne scarring common
Lack of high-quality evidence
Negative psychosocial impact

Acne scars are a common complication that can negatively affect people's mental and physical well-being. Many treatments have been suggested, but high-quality evidence is lacking. This review focuses on treatments for indented (atrophic) acne scars on the face, with limited information on raised (hypertrophic) scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Fractional CO<sub>2</sub> laser treatment of caesarean section scars-A randomized controlled split-scar trial with long term follow-up assessment.

Author: KarmisholtKatrine E, TaudorfElisabeth H, WulffCamilla B, WenandeEmily, PhilipsenPeter A, HaedersdalMerete

Improved scar pliability
New collagen and elastic fibers
Smoother scar surface
Transient erythema and hyperpigmentation

Ablative fractional laser (AFXL) treatment for mature c-section scars initiated scar remodeling 1 month after treatment, but overall scar improvement was concealed until laser-induced color changes resolved. At 6 months follow-up, the benefit of AFXL treatment on c-section scars emerged.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Safety and Efficacy Evaluation of Pulsed Dye Laser Treatment, CO<sub>2</sub> Ablative Fractional Resurfacing, and Combined Treatment for Surgical Scar Clearance.

Author: CohenJoel L, GeronemusRoy

Scar treatment
Surgical scar cosmesis

This study evaluated the efficacy and safety of pulsed dye laser treatment, CO2 ablative fractional resurfacing, and combined treatment for the cosmetic improvement of surgical scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

[Observation on the clinical application effects of skin distractor on the treatment of scars].

Author: GuiW L, YangE, ZhangH S

Better effects on scar treatment

This study investigated the effects of skin distractors with different pull speeds on scar treatment in various body areas. Results suggest that skin distractors are effective for scar treatment, and a slower pull speed of 2 mm/d may be more beneficial, particularly in the extremities.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

38.

Therapeutic effect of microneedling and autologous platelet-rich plasma in the treatment of atrophic scars: A randomized study.

Author: IbrahimZeinab A, El-AshmawyAmal A, ShoraOla A

Fewer sessions
Improved scar appearance

Combining skin needling and platelet-rich plasma was the most effective and safe treatment for atrophic scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

39.

Microneedling: Where do we stand now? A systematic review of the literature.

Author: RamautLisa, HoeksemaHenk, PirayeshAli, StillaertFilip, MonstreyStan

While there are options for improving the appearance of scars and wrinkles, many treatments are invasive and have potential side effects. Microneedling is a newer, non-invasive option for people who are concerned about the cosmetic effects of injuries, diseases, or aging.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial.

Author: AbediniRobabeh, SasaniPardis, MahmoudiHamid Reza, NasimiMaryam, TeymourpourAmir, ShadlouZahra

Keloid treatment
Ineffectiveness

Intralesional triamcinolone acetonide was effective in treating keloids and hypertrophic scars, while verapamil was not.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial.

Author: KhalidFarrukh Aslam, MehroseMuhammad Younas, SaleemMuhammad, YousafMuhammad Amin, MujahidAbdul Malik, RehmanSaif Ur, AhmadSania, TararMoazzam Nazeer

Lower recurrence rate
Scar reduction

A randomized controlled trial found that intralesional 5-FU plus TAC is a safe and effective treatment for keloids and hypertrophic scars, with a lower rate of recurrence (17.5%) compared to TAC alone (39.2%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Topical Tazarotene Gel, 0.1%, as a Novel Treatment Approach for Atrophic Postacne Scars: A Randomized Active-Controlled Clinical Trial.

Author: AfraT P, Razmi TMuhammed, NarangTarun, DograSunil, KumarAshok

Acne scar improvement
Quantitative severity

This prospective, observer-blinded, active-controlled, randomized clinical trial compared the efficacy of topical tazarotene gel, 0.1%, with microneedling therapy in the management of moderate to severe atrophic acne scars. Both treatments showed comparable outcomes for the overall improvement of quantitative facial acne scar severity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

43.

Efficacy of Combined Intense Pulsed Light (IPL) With Fractional CO<sub>2</sub> -Laser Ablation in the Treatment of Large Hypertrophic Scars: A Prospective, Randomized Control Trial.

Author: DaoudAlexander A, GianatasioChloe, RudnickAshley, MichaelMary, WaibelJillS

Effective scar treatment
Improved scar appearance

This study aimed to compare the effectiveness of a combination treatment using intense pulsed light (IPL) and fractional ablative CO<sub>2</sub> laser for mature hypertrophic scars with single-laser treatment using fractional ablative CO<sub>2</sub> laser alone or a control group. The study aimed to demonstrate the potential benefits of a multi-laser approach for comprehensive scar revision.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

44.

Combination Therapy of Microneedle Fractional Radiofrequency and Topical Poly-Lactic Acid for Acne Scars: A Randomized Controlled Split-Face Study.

Author: AnMin K, HongEun H, SuhSuk B, ParkEun J, KimKwang H

Improved scar appearance

Combination therapy with topical poly-lactic acid and microneedle fractional radiofrequency (MFRF) is a safe and effective treatment for acne scars. It resulted in better scar smoothness and smaller scar size compared to monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

45.

Comparative Efficacy and Safety of Common Therapies in Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis.

Author: BaoYawei, XuShanshan, PanZhipeng, DengJixiang, LiXinyi, PanFaming, LiXiaojing

Hypertrophic scar treatment
Keloid treatment

This meta-analysis found that TAC+5-FU may be the most effective therapy for keloids and hypertrophic scars, while verapamil may be a better therapeutic strategy for safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Laser pretreatment for the attenuation of planned surgical scars: A randomized self-controlled hemi-scar pilot study.

Author: FriedmanOr, GofsteinDina, AradEhud, GurEyal, SprecherEli, ArtziOfir

Presurgical laser treatment

This study evaluates the safety, efficacy, and cosmetic outcomes of a single presurgical laser treatment on surgical scar formation, demonstrating its potential to improve scar appearance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Evaluation of Microneedling Therapy in Management of Facial Scars.

Author: Vijaya LakshmiYenugandula, Swetha ReddyLingaladinne, Naga Neelima DeviKolli, Phani KumarKuchimanchi, Guru KarthikGandikota, Srinivas ChakravarthyPandi, Nageswar RaoKondrakunta

Improved facial scar treatment

This study evaluates the efficacy of microneedling therapy, also known as percutaneous collagen induction therapy, for managing facial scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

Clinical and histopathological comparison of microneedling combined with platelets rich plasma versus fractional erbium-doped yttrium aluminum garnet (Er: YAG) laser 2940 nm in treatment of atrophic post traumatic scar: a randomized controlled study.

Author: AgamiaN F, SorrorO, AlrashidyM, TawfikA A, BadawiA

Comparable to laser
Effective scar treatment

This study found that microneedling combined with PRP could be as effective as fractional Er:YAG laser in treating post-traumatic atrophic scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

49.

A split-face randomized controlled study comparing the efficacy and safety of intralesional radiofrequency-assisted subcision vs conventional subcision in postacne scars.

Author: KaurManinder, SharmaVinod K, SethuramanGomathy, AravaSudheer, GuptaSomesh

Reduced hematoma
Scar improvement
Entry point burn

This study compared the efficacy and safety of radiofrequency-assisted subcision (rSubcision) with conventional subcision for treating postacne scars. Both treatments showed significant improvement in scar appearance, with rSubcision resulting in slightly better patient-reported outcomes. However, rSubcision carries a small risk of burns while conventional subcision has a higher risk of hematoma formation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

Evaluation of Fractional CO<sub>2</sub> Versus Long Pulsed Nd:YAG Lasers in Treatment of Hypertrophic Scars and Keloids: A Randomized Clinical Trial.

Author: TawficShereen O, El-TawdyAmira, ShalabySuzan, FoadAhmed, ShakerOlfat, SayedSafinaz S, MetwallyDina

Scar treatment

A study of 30 patients with hypertrophic scars and keloids found that long pulsed Nd:YAG laser, fractional CO2 laser, and fractional CO2 laser combined with radiofrequency (RF) were all effective and safe treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Efficacy and Safety of Intralesional Triamcinolone Versus Combination of Triamcinolone with 5-Fluorouracil in the Treatment of Keloids and Hypertrophic Scars: A Systematic Review and Meta-analysis.

Author: JiangZheng-Ying, LiaoXin-Cheng, LiuMing-Zhuo, FuZhong-Hua, MinDing-Hong, YuXiao-Ting, GuoGuang-Hua

Improved keloid and hypertrophic scar treatment

This review examined the efficacy and safety of intralesional triamcinolone acetonide (TAC) and combination therapy with 5-fluorouracil (5-FU) for treating keloids and hypertrophic scars, highlighting the need for more research on these treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Prevention of Scarring With Intraoperative Erbium: YAG Laser Treatment.

Author: KolliHiren, MoyRonald L

Improved scar appearance

This study evaluated the efficacy of a 2,940-nm fractional erbium:YAG laser to improve scar appearance when used immediately after skin closure. The study found that the laser treatment performed immediately after surgery can improve the appearance of a surgical scar.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

53.

Comparing the Efficacy and Safety of Intralesional Verapamil With Intralesional Triamcinolone Acetonide in Treatment of Hypertrophic Scars and Keloids: A Meta-Analysis of Randomized Controlled Trials.

Author: WangPu, GuLuosha, BiHongsen, WangQifei, QinZelian

Skin atrophy
Telangiectasia

A meta-analysis of seven randomized controlled trials (461 patients) compared the efficacy and safety of intralesional injections of triamcinolone acetonide (TAC) and verapamil for the treatment of hypertrophic scars (HSs) and keloids. TAC resulted in faster improvement in scar height and pliability but no significant differences in other outcomes compared to verapamil. Verapamil was associated with significantly lower rates of telangiectasia and skin atrophy compared to TAC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

54.

Strontium-90 brachytherapy following intralesional triamcinolone and 5-fluorouracil injections for keloid treatment: A randomized controlled trial.

Author: DengKe, XiaoHaitao, LiuXiaoxue, OgawaRei, XuXuewen, LiuYong

Hormonal imbalance
Irregular menstruation
Pain

There is no single most effective treatment for keloid scars, and recurrence is common. Intralesional corticosteroid injections are the most common treatment for small, young keloids and hypertrophic scars.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Evaluation of Efficacy of Corticosteroid and Corticosteroid Combined with Botulinum Toxin Type A in the Treatment of Keloid and Hypertrophic Scars: A Meta-Analysis.

Author: LiuXiao-Gang, ZhangDuo

Intralesional corticosteroid injection for keloid and hypertrophic scars

This study explored the effectiveness of intralesional corticosteroid injections alone versus in combination with botulinum toxin type A for treating keloid and hypertrophic scars. While both treatments have shown promise, the difference in efficacy between the two approaches remains controversial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

57.

Silicone gel sheeting for treating hypertrophic scars.

Author: JiangQingling, ChenJunjie, TianFan, LiuZhenmi

Scar treatment

This study investigates the effectiveness of silicone gel sheeting (SGS) for treating hypertrophic scars, which can significantly impact quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

58.

Effectiveness of a combination therapy using non-ablative fractional laser and intralesional triamcinolone injection for thyroidectomy scar treatment: a prospective, randomized, blinded pilot study.

Author: CheonJeong Hyun, HwangYong Jae, YoonEul Sik, JungKwang Yoon, ParkSeung-Ha, ChungJae Ho

Scar prevention

This study investigates whether using a combination of treatments soon after thyroid surgery can help minimize scarring. While many approaches exist to treat scars, the study explores the potential benefits of early intervention with multiple therapies to reduce scar formation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

59.

Single-center, assessor-blind study to evaluate the efficacy and safety of DA-5520 topical gel in patients with acne scars: A pilot study.

Author: HanHye Sung, ParkJae Wan, ShinSun Hye, YooKwang Ho, SohnYoung Sung, KimBeom Joon

Acne scar treatment

This 12-week study evaluated the safety and efficacy of DA-5520, a topical gel for the treatment of acne scars. Participants were randomized to receive either laser resurfacing or comedone extraction with or without DA-5520 application. Clinical improvement of acne scars was observed after using DA-5520, both when combined with laser resurfacing or individually. No adverse reactions were noted.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

60.

Aesthetic Nonexcisional Arm Contouring.

Author: IbrahiemSaad Mohamed Saad

Improved arm contouring
Reduced skin laxity

Energy-assisted liposuction techniques, such as radiofrequency-assisted liposuction and Renuvion helium subdermal coagulation, can achieve significant improvements in skin laxity and fat reduction for arm contouring.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

61.

A one-time pneumatic jet-injection of 5-fluorouracil and triamcinolone acetonide for treatment of hypertrophic scars-A blinded randomized controlled trial.

Author: ErlendssonAndrés M, RosenbergLukas K, LercheCatharina M, Togsverd-BoKatrine, WiegellStine R, KarmisholtKatrine, PhilipsenPeter A, HansenAnders C N, JanfeltChristian, HolmesJon, RossiAnthony, HaedersdalMerete

Reduced scar height
Reduced scar pliability

A single needle-free pneumatic jet injection (PJI) containing 5-fluorouracil (5-FU) and triamcinolone acetonide (TAC) can significantly improve the height and pliability of hypertrophic scars (HTS).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

Autologous platelet-rich plasma 'fluid' versus 'gel' form in combination with fractional CO<sub>2</sub> laser in the treatment of atrophic acne scars: a split-face randomized clinical trial.

Author: GawdatHeba I, El-HadidyYasmin Ahmed, AllamRiham S H M, AbdelkaderHeba Ahmed

Acne scar treatment
Improved skin appearance
Further research needed
Limited sample size

A study of 27 patients with atrophic acne scars found that both platelet-rich-plasma (PRP) fluid and PRP gel combined with fractional CO2 laser treatment resulted in significant improvement in clinical assessment scores at 3 months compared to 1 month.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

63.

Effectiveness of Botulinum Toxin Type A Injection on Scars: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Author: LiMan-Yun, ChiuWen-Kuan, WangHsian-Jenn, ChenI-Fan, ChenJin-Hua, ChangTa-Pang, KoYu, ChenChiehfeng

Scar treatment
None reported

This systematic review of 21 randomized controlled trials evaluated the effectiveness of botulinum toxin type A (BoNT-A) for treating scars. BoNT-A was more effective than saline in treating scars, though steroids may be more potent. BoNT-A can be considered an alternative treatment for patients who are not suitable for steroid treatment.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

64.

Comparing the Efficacy of Multiple Drugs Injection for the Treatment of Hypertrophic Scars and Keloid: A Network Meta-Analysis.

Author: WuWenhao, ZhaoYang, ChenYuxuan, ZhongAimei

Scar treatment

This study aims to determine the most effective drugs for treating pathological scars, as there is no consensus on the best treatment approach despite many randomized controlled trials showing varying results.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

65.

Keloid treatments: an evidence-based systematic review of recent advances.

Author: WalshLaura A, WuEllen, PontesDavid, KwanKevin R, PoondruSneha, MillerCorinne H, KunduRoopal V

Keloid treatment

This review of 108 prospective studies found that silicone gel or sheeting with corticosteroid injections is the first-line therapy for keloids. Other treatments, such as adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil, laser therapy, excision with immediate post-excision radiation therapy, and pressure therapy may also be considered.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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