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Similar effects of atorvastatin, simvastatin and pravastatin on thrombogenic and inflammatory parameters in patients with hypercholesterolemia.

Author: DornerG T, JoukhadarC, KleinN, PrinzM, SchmettererL, SchrolnbergerC, VukovichT, WolztM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Statins may have beneficial effects beyond their lipid-lowering effects, potentially including reducing cardiovascular morbidity and mortality. However, further research is needed to determine whether all statins elicit these effects.
Paper Details　
Original Abstract of the Article :
Previous studies have suggested that statins exert beneficial effects beyond their favorable lipid lowering effect. Particularly, the modification of thrombus formation and degradation, alteration in inflammatory response, plaque stabilization and improved endothelial function are thought to be resp...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/11204586

データ提供：米国国立医学図書館（NLM）

Statins: Beyond Cholesterol Reduction

The field of cardiovascular medicine is constantly exploring the mechanisms of action of medications used to treat heart disease. This study investigates the effects of statins, a class of drugs commonly used to lower cholesterol, on thrombogenic and inflammatory parameters. The researchers compared the effects of atorvastatin, simvastatin, and pravastatin on these parameters in patients with hypercholesterolemia. Their findings suggest that statins may exert beneficial effects beyond their lipid-lowering properties, potentially reducing the risk of cardiovascular events.

Statins May Offer Additional Cardiovascular Benefits

The study found that all three statins had similar effects on thrombogenic and inflammatory parameters, suggesting that these effects are not specific to a particular statin. This suggests that statins may offer a broader range of cardiovascular benefits beyond their lipid-lowering effects.

Understanding the Pleiotropic Effects of Statins

This research highlights the pleiotropic effects of statins, meaning that they have multiple actions beyond their primary function. This underscores the importance of considering the full range of benefits and risks when prescribing statins for patients with cardiovascular disease.

Dr.Camel's Conclusion

Just as a camel needs to adapt to the harsh conditions of the desert, our bodies need to adapt to maintain optimal health. This study suggests that statins may offer multiple benefits for cardiovascular health, extending beyond their cholesterol-lowering effects.

Date :
  1. Date Completed 2001-06-07
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

11204586

DOI: Digital Object Identifier

01010047

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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