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First clinical experience with the rapid-, short-acting amiodarone derivative E 047/1 after cardiac surgery.

Author: GombotzH, MahlaE, MetzlerH, RehakP, VicenziM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

E 047/1, a derivative of amiodarone, is effective for treating cardiac dysrhythmias.
Paper Details　
Original Abstract of the Article :
Amiodarone is very effective against a variety of dysrhythmias but has poor pharmacodynamic properties and many undesired side-effects. Its short- and rapid-acting derivative E 047/1 may circumvent some of these drawbacks. It is easier to titrate while retaining the high efficacy of amiodarone and m...See full text at original site
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引用元：
https://doi.org/10.1017/s0265021502000042

データ提供：米国国立医学図書館（NLM）

A Novel Approach to Treating Cardiac Arrhythmias: E 047/1

This research, in the field of [Cardiology and Pharmacology], examines a novel approach to the treatment of [cardiac dysrhythmias]. The authors explore the potential of E 047/1, a [rapid- and short-acting derivative of amiodarone], to address the [limitations and side effects] associated with traditional amiodarone therapy. This investigation focuses on the use of E 047/1 in patients who experience [serious ventricular tachydysrhythmias] after cardiac surgery.

E 047/1: A Potential Game-Changer in Cardiac Arrhythmia Management

This research offers compelling evidence for the potential of E 047/1 as a safe and effective treatment option for [cardiac arrhythmias]. The authors highlight its [efficacy and favorable pharmacodynamic properties] compared to traditional amiodarone. The ability to [easily titrate the dosage] and its [potential for acceptable influences on haemodynamics and cardiac conduction] represent significant advantages. This research suggests that E 047/1 may be a valuable tool in the fight against [destabilizing ventricular tachydysrhythmias], providing much-needed hope for patients experiencing these life-threatening conditions.

Navigating the Labyrinth of Heart Rhythms: A New Path Forward

This research provides a glimmer of hope for individuals battling [cardiac arrhythmias]. The development of E 047/1 may offer a safer and more effective alternative to traditional treatment options. Remember, a healthy heart is a beating heart, and this research paves the way for a brighter future for those struggling with [irregular heart rhythms].

Dr. Camel's Conclusion

E 047/1 presents a promising new approach to treating cardiac arrhythmias, potentially offering patients a smoother ride through the often-treacherous landscape of heart rhythms. This research is a reminder that even in the vast desert of scientific knowledge, new discoveries and innovations can emerge, offering hope and brighter horizons for those facing challenging medical conditions.

Date :
  1. Date Completed 2002-10-10
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

11913800

DOI: Digital Object Identifier

10.1017/s0265021502000042

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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