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Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives.

Author: , LeonettiGastone, MagnaniBruno, PessinaAchille Cesare, RappelliAlessandro, TrimarcoBruno, ZanchettiAlberto

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This trial compared the tolerability of lercanidipine, a calcium antagonist, to two other calcium antagonists (amlodipine and lacidipine) in elderly hypertensive patients. The study aimed to evaluate the side effects associated with these antihypertensive drugs.
Paper Details　
Original Abstract of the Article :
Irrespective of their clinical relevance, side effects cannot be considered a negligible problem in antihypertensive therapy. The aim of this trial was to evaluate the tolerability profile of lercanidipine with that of two other calcium antagonists (amlodipine and lacidipine) in elderly hypertensive...See full text at original site
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引用元：
https://doi.org/10.1016/s0895-7061(02)03000-5

データ提供：米国国立医学図書館（NLM）

Evaluating Tolerability of Antihypertensive Medications

The field of hypertension research is constantly searching for effective and well-tolerated treatments. This study delves into the tolerability of lercanidipine, a calcium channel blocker, compared to two other popular calcium channel blockers, amlodipine and lacidipine, in elderly hypertensives. The study employed a meticulous approach, evaluating side effects and their impact on the overall treatment experience for these patients. The researchers sought to identify the most suitable drug for elderly patients based on its tolerability profile.

Tolerability Matters for Long-Term Success

The study revealed that while all three drugs exhibited efficacy in controlling blood pressure, lercanidipine was found to have a more favorable tolerability profile in elderly hypertensives. This finding suggests that lercanidipine could be a valuable option for managing hypertension in this population, particularly for those who may be more sensitive to side effects. The research emphasizes the importance of considering individual patient characteristics and tolerability when choosing an antihypertensive medication.

Choosing the Right Treatment for Elderly Hypertensives

This study offers valuable insights for healthcare professionals when treating elderly hypertensives. The findings suggest that lercanidipine might be a suitable option for patients who experience side effects with other calcium channel blockers. However, it's important to note that individual responses to medications can vary, and personalized treatment plans are crucial.

Dr. Camel's Conclusion

Just like a camel navigating a vast desert, finding the right medication for hypertension is about finding the most suitable path for each individual. This study highlights the importance of considering tolerability, especially in elderly patients, when selecting antihypertensive medication. It's like choosing the right camel for the journey - one that can carry the load without causing too much discomfort.

Date :
  1. Date Completed 2003-07-10
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

12441211

DOI: Digital Object Identifier

10.1016/s0895-7061(02)03000-5

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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