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Effects of amiodarone and diltiazem on persistent atrial fibrillation conversion and recurrence rates: a randomized controlled study.

Author: DermitzakiDespina N, KallergisEleftherios M, KambourakiDespina C, KanoupakisEmmanuel M, ManiosEmmanuel G, MavrakisHercules E, VardasPanos E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Oral amiodarone increases conversion rates, prolongs fibrillatory cycle length and atrial effective refractory period, and preserves sinus rhythm after cardioversion in persistent AF patients.
Paper Details　
Original Abstract of the Article :
PURPOSE: To assess the effects of amiodarone and diltiazem on atrial fibrillation (AF) induced atrial electrical remodeling and their clinical implications. METHODS: Persistent AF patients were randomly assigned to three treatment groups over a period from 6 weeks before to 6 weeks after internal c...See full text at original site
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引用元：
https://doi.org/10.1023/a:1024203824761

データ提供：米国国立医学図書館（NLM）

Taming the Rhythms of the Heart: Amiodarone vs. Diltiazem in Atrial Fibrillation

The human heart is a complex symphony, with intricate electrical patterns governing its rhythmic beat. Atrial fibrillation, a common heart rhythm disorder, disrupts this harmonious rhythm, causing the heart to beat irregularly and erratically. This study delved into the desert of atrial fibrillation, investigating the effects of two medications, amiodarone and diltiazem, on restoring the heart's normal rhythm. The researchers conducted a carefully controlled trial, comparing the effectiveness of these drugs in patients with persistent atrial fibrillation.

Amiodarone: A Stronger Beat

The study found that amiodarone was more effective than diltiazem in restoring normal heart rhythm, with higher conversion rates and a greater probability of maintaining sinus rhythm after cardioversion. Moreover, amiodarone significantly reduced the number of atrial ectopics, those rogue electrical signals that trigger the erratic fibrillation. These findings suggest that amiodarone might have a greater ability to calm the chaotic electrical storm of atrial fibrillation.

A Rhythm for Life

Understanding the nuances of atrial fibrillation treatment is crucial for improving patient outcomes. This study provides valuable insights into the effectiveness of amiodarone and diltiazem, guiding clinicians in their efforts to restore the heart's natural rhythm. It's a reminder that even in the vast desert of heart rhythm disorders, there are effective therapies that can help patients lead healthy and fulfilling lives.

Dr.Camel's Conclusion

This study provides valuable insights into the comparative efficacy of amiodarone and diltiazem in treating persistent atrial fibrillation. The study highlights the potential of amiodarone in restoring normal heart rhythm and reducing the occurrence of atrial ectopics, offering a glimmer of hope in the desert of this prevalent heart rhythm disorder.

Date :
  1. Date Completed 2003-12-02
  2. Date Revised 2019-09-16
Further Info :

Pubmed ID

12843685

DOI: Digital Object Identifier

10.1023/a:1024203824761

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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