Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma.

Author: BanerjiDonald, KunduSudeep, LloydMark, RohatagiShashank, SzeflerStanley, WilliamsJames

Paper Details 
Original Abstract of the Article :
BACKGROUND: Inhaled corticosteroids (ICSs) reduce local airway inflammation, which is an underlying cause of asthma symptoms. However, potential systemic side effects associated with ICS use are a major concern for asthmatic patients. METHODS: Adult patients (n = 60; > or = 18 years of age) with mo...See full text at original site
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引用元:
https://doi.org/10.1378/chest.128.3.1104

データ提供:米国国立医学図書館(NLM)

Ciclesonide: A Gentle Breeze in the Desert of Asthma

This research investigates the potential [systemic effects] of ciclesonide, a novel inhaled corticosteroid, in patients with moderate-to-severe asthma. The study utilizes [a randomized controlled trial] to compare the effects of different doses of ciclesonide and fluticasone propionate, another inhaled corticosteroid, to placebo. The researchers found that ciclesonide, even at high doses, did not significantly suppress hypothalamic-pituitary-adrenal axis function, suggesting a potential advantage over other inhaled corticosteroids. The study highlights the importance of considering potential side effects and optimizing treatment regimens for asthma management.

Finding Balance: Asthma Treatment Strategies

Asthma can be like navigating a vast and unpredictable desert, where sudden shifts in the wind can trigger severe symptoms. This study explores the potential of ciclesonide, a novel inhaled corticosteroid, to manage asthma without significantly impacting the body's natural hormonal balance. The findings suggest that ciclesonide may provide a gentler approach to asthma management, potentially reducing the risk of side effects associated with other inhaled corticosteroids.

Navigating the Desert of Asthma: A Gentle Approach

This research offers a promising oasis of hope for patients with asthma. The study's findings suggest that ciclesonide, a novel inhaled corticosteroid, may provide a safer and more effective alternative to other inhaled corticosteroids, potentially reducing the risk of systemic side effects while effectively controlling asthma symptoms. This research provides valuable insights into the potential of ciclesonide for managing asthma, offering a gentler approach for navigating the desert of this chronic condition.

Dr.Camel's Conclusion

This study explores the safety and efficacy of ciclesonide, a novel inhaled corticosteroid, in patients with asthma. The findings suggest that ciclesonide, even at high doses, does not significantly suppress hypothalamic-pituitary-adrenal axis function, potentially offering a gentler and safer alternative to other inhaled corticosteroids. Further research is warranted to explore the long-term benefits of ciclesonide for managing asthma and improving the lives of patients.

Date :
  1. Date Completed 2005-11-08
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

16162694

DOI: Digital Object Identifier

10.1378/chest.128.3.1104

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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