Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals.

Author: AcostaEdward P, CliffordDavid B, DorfmanDavid, EvansScott, GoodkinKarl, GulickRoy M, RibaudoHeather, SimpsonDavid, TashimaKaren, YangYijun

Paper Details 
Original Abstract of the Article :
BACKGROUND: Efavirenz is a commonly used antiretroviral drug that causes neurologic side effects in more than 50% of patients. OBJECTIVE: To characterize efavirenz-associated neurologic symptoms in a randomized, controlled study of initial antiretroviral treatment. DESIGN: Substudy of a randomized...See full text at original site
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引用元:
https://doi.org/10.7326/0003-4819-143-10-200511150-00008

データ提供:米国国立医学図書館(NLM)

Efavirenz and the Brain: A Study of Neuropsychological Effects

In the ongoing fight against [HIV/AIDS], researchers constantly evaluate the effects of [antiretroviral medications] on both [physical health] and [mental well-being]. This study delves into the neuropsychological impact of [efavirenz], a commonly used antiretroviral drug, in patients initiating [antiretroviral therapy].

Efavirenz: A Neuropsychological Journey

The study revealed that [efavirenz] was associated with [neurologic symptoms] in some patients, primarily during the early stages of therapy. However, these symptoms generally resolved within [4 weeks]. Notably, [neuropsychological performance] improved over time in both groups receiving efavirenz and those not receiving it, suggesting that the drug's effects on cognitive function might be transient and not detrimental in the long run.

Navigating the Side Effects: A Balanced Approach

The study underscores the need for careful monitoring of patients receiving [efavirenz], particularly during the initial phase of treatment. Early detection and management of any neurologic symptoms are crucial to ensuring optimal patient outcomes. While the study suggests that efavirenz's effects on cognitive function are generally temporary, further research is necessary to better understand the drug's long-term impact on the brain.

Dr.Camel's Conclusion

Just as a desert traveler must be cautious of mirages, we must be aware of potential side effects of medications. This study sheds light on the neuropsychological effects of efavirenz, highlighting the importance of careful monitoring and individualized treatment approaches. While the journey through HIV treatment can be challenging, understanding these effects allows us to navigate the path with greater awareness and precision.

Date :
  1. Date Completed 2005-11-28
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

16287792

DOI: Digital Object Identifier

10.7326/0003-4819-143-10-200511150-00008

SNS
PICO Info
in preparation
Languages

English

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