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Atomoxetine attenuates dextroamphetamine effects in humans.

Author: HillKevin, KostenThomas, PolingJames, SofuogluMehmet

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Atomoxetine, a norepinephrine transporter inhibitor, attenuated some of the physiological and subjective responses to dextroamphetamine in healthy volunteers. This supports the role of the noradrenergic system in mediating acute amphetamine responses and suggests potential use for stimulant addiction.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Although preclinical studies support the contribution of the noradrenergic system activation in mediating the acute effects of amphetamines, these findings have not been followed up in clinical studies. OBJECTIVES: To examine the effects of atomoxetine, a norepinephrine transporter inhi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20014909

データ提供：米国国立医学図書館（NLM）

The Impact of Atomoxetine on Dextroamphetamine Effects

The world of pharmacology is like a vast desert, with hidden oases of knowledge waiting to be discovered. This study delves into the effects of atomoxetine, a medication commonly used for attention-deficit/hyperactivity disorder (ADHD), on the stimulant effects of dextroamphetamine. The researchers used a group of healthy volunteers to study how atomoxetine affects the way dextroamphetamine impacts things like blood pressure, cortisol levels, and subjective feelings.

The study employed a double-blind, crossover design, meaning that participants received both atomoxetine and a placebo, but neither they nor the researchers knew which they were getting at any given time. This meticulous approach helped ensure that the results weren't influenced by expectations or biases.

Atomoxetine's Influence on Dextroamphetamine

The study's results showed that atomoxetine significantly dampened the effects of dextroamphetamine on blood pressure and cortisol levels. Additionally, participants reported feeling less stimulated, high, and experiencing fewer 'good drug effects' when they were taking atomoxetine. These findings suggest that atomoxetine might help reduce some of the physiological and subjective effects of amphetamines.

Atomoxetine's Potential in Addiction Treatment

The study's results offer a glimmer of hope for people struggling with stimulant addiction. If atomoxetine can successfully reduce the pleasurable and stimulating effects of amphetamines, it could potentially play a role in addiction treatment and help people manage cravings and withdrawal symptoms. Of course, more research is needed before this becomes a reality, but this study provides a promising starting point.

Dr.Camel's Conclusion

It's like a camel traversing the desert, seeking a cool oasis to quench its thirst. Atomoxetine acts as a calming force, reducing the intense 'high' of dextroamphetamine. While we are still on the journey to understanding its full potential, this study reveals a possible path for treating stimulant addiction and offering hope for those struggling in the desert of dependency.

Date :
  1. Date Completed 2010-02-26
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20014909

DOI: Digital Object Identifier

NIHMS157272

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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