Treatment of essential hypertension in Asians: enalapril as monotherapy versus combination therapy with hydrochlorothiazide.

Author: JonesD W, SandsC D

Paper Details 
Original Abstract of the Article :
This study compared enalapril maleate (Enaprin) as a single antihypertensive agent and enalapril plus hydrochlorothiazide in Korean patients to determine if one regimen is superior to the other in terms of efficacy and subjective adverse effects. After a 1-week washout period, 12 patients were rando...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/2052467

データ提供:米国国立医学図書館(NLM)

Comparing Enalapril Therapies for High Blood Pressure in Asians

The realm of [hypertension research] is filled with endless possibilities and challenges. This study delves into the world of [antihypertensive therapies] focusing on [enalapril] as a treatment for [essential hypertension] in [Asians]. The researchers employed a [randomized controlled trial] to investigate the effectiveness of [enalapril monotherapy] versus [combination therapy with hydrochlorothiazide]. They discovered that the [combination therapy] was more effective in lowering blood pressure and required a lower dose of enalapril compared to the monotherapy. These findings hold significance for [Asian hypertensives] and contribute to our understanding of [optimal blood pressure management]. A particularly intriguing aspect is the [lower dosing requirement] for combination therapy, which could potentially minimize [potential side effects] associated with higher doses of enalapril.

Combination Therapy Proves Superior in Lowering Blood Pressure

The study results demonstrate the [superior efficacy] of [combination therapy] in lowering [diastolic blood pressure], achieving a reduction of [25.1 mm Hg] compared to [10.7 mm Hg] with [enalapril alone]. This statistically significant difference (p < 0.01) provides compelling evidence for the effectiveness of the [combination therapy]. Furthermore, the study noted a [reduced enalapril dosage requirement] for combination therapy (13.0 mg) compared to monotherapy (18.8 mg), underscoring the [potential benefits] in terms of [reduced side effect risk] and [improved patient tolerability].

Implications for Blood Pressure Management in Asians

The findings suggest that [combination therapy with hydrochlorothiazide] may offer a [more effective and safer] approach to [blood pressure management] in [Asian hypertensives]. These results provide valuable insights for [healthcare professionals] and contribute to [evidence-based decision-making] regarding [antihypertensive therapy choices]. The research findings emphasize the importance of [personalized medicine] and the need to consider [ethnic differences] when developing [treatment strategies] for [hypertension].

Dr.Camel's Conclusion

This study is like a compass guiding us through the desert of high blood pressure, pointing towards a more effective and safer path for Asian patients. Combination therapy with hydrochlorothiazide seems to be the winning camel in this race, offering a faster and smoother journey to lower blood pressure with potentially fewer side effects. Remember, everyone's journey is unique, so it's crucial to consult with your doctor to find the right camel for your specific needs.

Date :
  1. Date Completed 1991-07-19
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2052467

DOI: Digital Object Identifier

2052467

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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