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Comparison of the behavioral and cardiovascular effects of intranasal and oral d-amphetamine in healthy human subjects.

Author: BabalonisShanna, EmurianCleeve, KellyThomas H, LileJoshua A, MartinCatherine A, WermelingDaniel P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

This study compared the effects of intranasal versus oral administration of d-amphetamine in healthy volunteers. Intranasal administration resulted in a faster onset of stimulant effects, including increased heart rate and blood pressure, and improved performance on a cognitive task. These findings may explain the popularity of intranasal d-amphetamine use and highlight its potential for abuse.
Paper Details　
Original Abstract of the Article :
Recent reports indicate an increase in intranasal use of prescription oral stimulant medication. However, there do not appear to be any published clinical studies that have characterized the behavioral and cardiovascular effects of intranasally administered d-amphetamine, which is commonly prescribe...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20671295

データ提供：米国国立医学図書館（NLM）

Exploring the Effects of Intranasal d-Amphetamine

This study delves into the effects of intranasal d-amphetamine, a stimulant medication commonly prescribed for Attention Deficit Hyperactivity Disorder (ADHD). The researchers compare the behavioral and cardiovascular effects of intranasal administration to oral administration, aiming to understand the potential implications of this increasingly common practice.

Intranasal d-Amphetamine: Faster Onset and Potential Risks

The study found that intranasal d-amphetamine produced similar stimulant effects as oral administration, but the onset of these effects was much faster. This could contribute to the popularity of intranasal use but also increase the risk of abuse. The study also revealed that intranasal administration resulted in a more rapid onset of stimulant effects, which could be associated with the popularity of intranasal prescription stimulant use and an enhanced potential for abuse.

Understanding the Risks of Intranasal d-Amphetamine

This research highlights the importance of understanding the potential risks and consequences of intranasal administration of d-amphetamine. It underscores the need for careful monitoring and responsible use of stimulant medications.

Dr. Camel's Conclusion

This study is like a compass guiding us through the complex terrain of stimulant medication use. It reveals the potential consequences of intranasal administration and underscores the importance of responsible medication practices. We must navigate this path with caution and awareness, ensuring the safe and effective use of these powerful medications.

Date :
  1. Date Completed 2011-09-06
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20671295

DOI: Digital Object Identifier

NIHMS469106

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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