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Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies.

Author: BindaClaudia, BoniventoDaniele, EdmondsonDale E, MatteviAndrea, MilczekErika M, WangJin

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

MAO inhibitors (MAOIs) are used for Parkinson's disease and depression. Safinamide, a selective MAO B inhibitor, shows neuroprotective effects. Rasagiline is used in combination with L-dopa and its metabolic products also have neuroprotective effects.
Paper Details　
Original Abstract of the Article :
Playing a pivotal role in the metabolism of neurotransmitters in the central nervous system, the mitochondrial enzymes monoamine oxidases A and B (MAO A and B) have been for long studied as drug targets for neurodegenerative and neurological diseases. MAO inhibitors (MAOIs) are clinically used to tr...See full text at original site
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引用元：
https://doi.org/10.2174/156802611798184355

データ提供：米国国立医学図書館（NLM）

Monoamine Oxidase Inhibition: A Multifaceted Approach to Neuroprotection

The field of [neurodegenerative diseases] is grappling with the intricate mechanisms underlying these debilitating conditions and seeking innovative strategies for treatment. This study explores the potential of [monoamine oxidase (MAO) inhibitors] in neuroprotection, examining their role in regulating [neurotransmitter metabolism] and their potential to mitigate [oxidative stress].

Unraveling the Mystery of Neuroprotection: MAO Inhibitors Offer Promising Avenues

The study highlights the multifaceted nature of MAO inhibitors, suggesting that their neuroprotective effects may extend beyond simply inhibiting neurotransmitter degradation. This adds a new layer of understanding to the potential therapeutic benefits of these drugs, emphasizing their potential to combat oxidative stress in the brain.

A Promising Future: MAO Inhibitors and Neuroprotection

The study suggests that MAO inhibitors may hold promise for the treatment and prevention of neurodegenerative diseases. While further research is needed to fully elucidate their mechanisms of action and long-term effects, the study underscores the importance of exploring multi-target approaches to combat these complex disorders.

Dr. Camel's Conclusion

Like a desert oasis providing respite from the harsh elements, MAO inhibitors may offer protection against the damaging effects of neurodegeneration. This study unveils the potential of these drugs to combat oxidative stress and regulate neurotransmitter levels, suggesting that they could play a significant role in the future of neuroprotective therapies.

Date :
  1. Date Completed 2012-06-11
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

22039878

DOI: Digital Object Identifier

10.2174/156802611798184355

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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