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Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Author: BombardierClaire, GhogomuElizabeth Tanjong, KatchamartWanruchada, OrtizZulma, RaderTamara, SheaBeverley, SwindenMichael V, TugwellPeter, WellsGeorge A
Original Abstract of the Article :
OBJECTIVE: To perform a systematic review of the benefits and harms of folic acid and folinic acid in reducing the mucosal, gastrointestinal, hepatic, and hematologic side effects of methotrexate (MTX); and to assess whether folic or folinic acid supplementation has any effect on MTX benefit. METHO...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.3899/jrheum.130738
データ提供:米国国立医学図書館(NLM)
Folic Acid and Folinic Acid: Oasis in the Methotrexate Desert
Methotrexate (MTX), a commonly used medication for rheumatoid arthritis (RA), can sometimes feel like a harsh desert, with potential side effects like nausea, vomiting, and liver dysfunction. This research delves into the potential of folic acid and folinic acid in mitigating these side effects.
The study, conducted as a systematic review of randomized controlled trials, analyzes the benefits and harms of folic acid and folinic acid supplementation in RA patients receiving MTX therapy. The findings suggest that folic acid and folinic acid supplementation can significantly reduce the risk of gastrointestinal and hepatic side effects associated with MTX, potentially improving patient tolerance and adherence to treatment.
A Protective Oasis for RA Patients
The study reveals that folic acid and folinic acid supplementation can significantly reduce the risk of gastrointestinal and hepatic side effects associated with MTX therapy in RA patients. It suggests that these supplements can play a crucial role in improving patient tolerance and adherence to MTX treatment, ultimately improving treatment outcomes.
Navigating the Methotrexate Desert
This research highlights the importance of considering potential side effects and mitigating strategies when prescribing MTX for RA. It suggests that folic acid and folinic acid supplementation can provide a protective oasis, reducing the risk of side effects and improving patient well-being.
Dr. Camel's Conclusion
This study offers a comprehensive exploration of the potential benefits of folic acid and folinic acid supplementation in mitigating MTX-related side effects in RA patients. It underscores the importance of a multi-faceted approach to RA management, considering both medication and nutritional interventions to maximize treatment efficacy and minimize adverse effects.
Date :
- Date Completed 2015-02-19
- Date Revised 2022-03-30
Further Info :
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