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Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells.

Author: BakdashGhaith, KapsenbergMartien L, MasonLauren M K, de JongEsther C, van CapelToni M M

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Vitamin D is known to have immunosuppressive effects. This study investigated the immunosuppressive mechanisms of vitamin D3 (cholecalciferol) and 25-hydroxy vitamin D3 (calcidiol), the precursors to the active form of vitamin D. Calcidiol, but not cholecalciferol, was found to effectively suppress immune responses by modulating dendritic cell function and promoting the development of regulatory T cells.
Paper Details　
Original Abstract of the Article :
Vitamin D is recognized as a potent immunosuppressive drug. The suppressive effects of vitamin D are attributed to its physiologically active metabolite 1,25 dihydroxy vitamin D3 (calcitriol), which was shown, to prime dendritic cells (DCs) to promote the development of regulatory T (Treg) cells. De...See full text at original site
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引用元：
https://doi.org/10.1016/j.vaccine.2014.08.075

データ提供：米国国立医学図書館（NLM）

Vitamin D: Beyond Bone Health, A Key to Immune Modulation

Vitamin D plays a crucial role in maintaining bone health, but its influence extends far beyond this single function. This research delves into the immune-modulating properties of vitamin D, specifically focusing on its effects on dendritic cells (DCs), key players in the adaptive immune response. The study explores the impact of vitamin D3 metabolites, including calcidiol and calcitriol, on DC function and the subsequent polarization of T cells.

Calcidiol's Powerful Influence on Immune Cell Differentiation

The study reveals that calcidiol, a vitamin D3 metabolite, possesses a potent immunomodulatory effect. It effectively primes DCs to promote the development of regulatory T cells (Tregs), which play a crucial role in suppressing excessive immune responses. This finding is particularly significant because calcidiol, unlike its more active metabolite calcitriol, exhibits a lower risk of hypercalcemia, making it a potentially safer therapeutic option.

Harnessing Vitamin D's Immunomodulatory Potential

This research highlights the potential of vitamin D, specifically calcidiol, in treating chronic inflammatory diseases. By promoting the development of Tregs, calcidiol could help to modulate the immune system, potentially preventing excessive inflammation and autoimmune reactions. Further research is needed to explore the clinical applications of calcidiol in treating conditions like allergies and autoimmune diseases.

Dr.Camel's Conclusion

Imagine a camel caravan crossing the desert, encountering a diverse landscape of shifting dunes and hidden oases. Vitamin D, like a wise camel guide, navigates the complex terrain of the immune system, promoting a harmonious balance. This study reveals the crucial role of calcidiol, a vitamin D metabolite, in shaping the immune response. It shows promise for treating inflammatory disorders, potentially offering a smoother and more balanced journey through the immune desert.

Date :
  1. Date Completed 2015-04-20
  2. Date Revised 2014-12-02
Further Info :

Pubmed ID

25236584

DOI: Digital Object Identifier

10.1016/j.vaccine.2014.08.075

SNS
PICO Info
in preparation
Languages

English

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