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Nature, time course and dose dependence of zidovudine-related side effects: results from the Multicenter Canadian Azidothymidine Trial.

Author: FalutzJ, FanningM, GelmonK, GillJ, MontanerJ S, O'ShaughnessyM, SmithJ R, TsoukasC, WainbergM, WellsG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Zidovudine treatment resulted in dose-dependent side effects, including nausea, fatigue, and headache, with a decrease in hemoglobin and bone marrow changes.
Paper Details　
Original Abstract of the Article :
To characterize the nature, time course and dose dependency of zidovudine-related side effects, we undertook a multicenter, prospective, dose-range finding study. Our study group consisted of 74 HIV-positive homosexual men belonging to groups II B, III and IV C2 from the Centers for Disease Control ...See full text at original site
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引用元：
https://doi.org/10.1097/00002030-198909000-00001

データ提供：米国国立医学図書館（NLM）

Zidovudine: Navigating the Side Effects in the Desert of HIV Treatment

The journey of HIV treatment is a complex and often challenging one, much like traversing a vast and unpredictable desert landscape. This research focuses on zidovudine, a crucial medication in the fight against HIV, and its potential side effects. It's like exploring the terrain of HIV treatment, carefully navigating the potential pitfalls and obstacles along the way.

The study characterized the nature, time course, and dose dependency of zidovudine-related side effects in a group of HIV-positive men. The authors found that the most common side effects were nausea, fatigue, and headache, generally self-limited and appearing briefly at each dose increment. They also observed dose-related decreases in certain blood cell counts. It's like encountering a series of sandstorms in the desert, each presenting a temporary challenge that can be managed with careful navigation and adjustments to the journey.

Zidovudine: Managing the Side Effects in the Desert of HIV Treatment

The study's findings highlight the importance of carefully managing the potential side effects of zidovudine, ensuring that patients receive the optimal benefits of this medication while minimizing potential risks. It's like finding a way to navigate a sandstorm safely, minimizing exposure to the harsh conditions and ensuring a smooth passage through the desert.

Navigating the Desert of HIV Treatment: A Journey of Discovery

This research emphasizes the importance of ongoing research and careful monitoring in the field of HIV treatment. It's like exploring a vast desert – there's always more to learn and understand. Further research is needed to develop new medications and optimize existing therapies, ensuring that we're always navigating toward the best possible outcomes for patients.

Dr. Camel's Conclusion

This research provides valuable insights into the potential side effects of zidovudine, a crucial medication in the fight against HIV. It's like finding a guidebook to navigate the desert of HIV treatment, helping us to understand the potential challenges and develop strategies for managing them. It's a journey of discovery, as we continue to seek new and innovative ways to combat this challenging disease.

Date :
  1. Date Completed 1989-11-20
  2. Date Revised 2019-07-18
Further Info :

Pubmed ID

2528969

DOI: Digital Object Identifier

10.1097/00002030-198909000-00001

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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