Effects and Side Effects of Using Sorafenib and Sunitinib in the Treatment of Metastatic Renal Cell Carcinoma.

Author: BauerJohann, GrimmDaniela, MagnussonNils E, Randrup HansenCaroline, WehlandMarkus

Paper Details 
Original Abstract of the Article :
In recent years, targeted therapies have proven beneficial in terms of progression-free survival (PFS) and overall survival (OS) in the treatment of metastatic renal cell carcinoma (mRCC). The tyrosine kinase inhibitors (TKIs) sorafenib and sunitinib are included in international clinical guidelines...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343994/

データ提供:米国国立医学図書館(NLM)

Sorafenib and Sunitinib: A Look at Targeted Therapies for Renal Cell Carcinoma

Metastatic renal cell carcinoma (mRCC) is a challenging type of kidney cancer, and targeted therapies have emerged as promising treatment options. This review examines the effects and side effects of sorafenib and sunitinib, two tyrosine kinase inhibitors (TKIs) commonly used for mRCC. The researchers evaluate the effectiveness of these drugs in terms of progression-free survival (PFS) and overall survival (OS), as well as their safety profiles.

Sorafenib and Sunitinib: Key Players in mRCC Treatment

The review highlights the significant role of sorafenib and sunitinib in the treatment of mRCC. These drugs have shown promise in terms of PFS and OS, providing valuable treatment options for patients with this challenging disease. However, the review also emphasizes the importance of considering the potential side effects, particularly hypertension, which can be a significant concern for some patients. It's like navigating a desert oasis where the refreshing water can also bring unexpected challenges.

Navigating the Evolving Landscape of mRCC Treatment

This review provides a comprehensive overview of the current landscape of targeted therapies for mRCC, highlighting both the benefits and limitations of sorafenib and sunitinib. The researchers acknowledge the emergence of newer targeted drugs and emphasize the need for further research to determine their optimal role in treating mRCC. It's a reminder that the desert of cancer research is constantly evolving, with new discoveries and innovations emerging regularly. Just as an explorer adapts to the changing terrain of a desert, we must remain adaptable in our approach to cancer treatment, embracing new technologies and strategies to improve patient outcomes.

Dr.Camel's Conclusion

This review highlights the dynamic landscape of mRCC treatment, with sorafenib and sunitinib playing vital roles. However, the emergence of newer targeted therapies necessitates further research to determine their optimal use and to improve patient outcomes. It's a reminder that the desert of cancer research is constantly evolving, requiring a persistent and innovative approach to find the best solutions for patients.

Date :
  1. Date Completed 2017-04-28
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

28230776

DOI: Digital Object Identifier

PMC5343994

SNS
PICO Info
in preparation
Languages

English

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