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Efficacy and safety of baked milk oral immunotherapy in children with severe milk allergy: A randomized, double-blind, placebo-controlled phase 2 trial.

Author: DantzerJennifer, DunlopJoan, KeetCorinne, PsoterKevin J, WoodRobert

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Baked milk oral immunotherapy (BMOIT) was well tolerated and induced a substantial level of desensitization in children allergic to baked milk, with 73% of participants tolerating 4044 mg of baked milk protein after 12 months.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Cow's milk allergy is the most common food allergy in young children and has no current treatment. Oral immunotherapy studies to date have shown efficacy but high rates of adverse reactions. OBJECTIVE: We sought to evaluate the safety and efficacy of baked milk oral immunotherapy (BMOIT...See full text at original site
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引用元：
https://doi.org/10.1016/j.jaci.2021.10.023

データ提供：米国国立医学図書館（NLM）

A New Hope for Milk Allergy Sufferers: Baked Milk Oral Immunotherapy

For many children, the enjoyment of a simple glass of milk is overshadowed by the fear of an allergic reaction. This study explores the potential of baked milk oral immunotherapy (BMOIT) as a new treatment for milk allergies. The researchers conducted a randomized, double-blind, placebo-controlled trial to evaluate the safety and efficacy of BMOIT in children with severe milk allergies. The results were promising: after 12 months of treatment, a significant portion of the participants in the BMOIT group were able to tolerate baked milk protein, whereas none of the participants in the placebo group showed improvement. While the study found that dose-related reactions were common, most were mild, suggesting that BMOIT could be a safe and effective treatment option.

A New Dawn for Milk Allergy Sufferers: A Tasty Oasis

This study offers a ray of hope for those struggling with milk allergies, demonstrating the potential of BMOIT to induce desensitization and improve tolerance. The findings suggest that BMOIT could be a safe and effective treatment option, potentially allowing individuals to enjoy dairy products without fear of a reaction. This research is a significant step forward in the quest to find effective treatments for food allergies.

Baking Towards a Brighter Future: A Delicious Solution

This study opens up a world of possibilities for individuals with milk allergies. The findings suggest that BMOIT could be a viable and safe option for those seeking to overcome their allergies and enjoy dairy products again. As researchers continue to explore the potential of BMOIT, we can look forward to a future where milk allergies are no longer a barrier to a healthy and fulfilling life.

Dr.Camel's Conclusion

This study demonstrates the efficacy and safety of baked milk oral immunotherapy (BMOIT) in children with severe milk allergy, offering a promising new treatment option for this common condition. The findings provide hope for a future where milk allergies are no longer a barrier to a healthy and fulfilling life.
Date :
  1. Date Completed 2022-04-12
  2. Date Revised 2022-07-19
Further Info :

Pubmed ID

34740607

DOI: Digital Object Identifier

10.1016/j.jaci.2021.10.023

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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