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Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis.

Author: BanhHoan Linh, HuYiyun, KungJanice Y, LiangLing, LiuShuang

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Angiotensin converting enzyme inhibitors (ACEIs) are known to cause dry cough. This systematic review and network meta-analysis ranked the risk of cough induced by different ACEIs and compared them to placebo, ARB, or CCB. Moexipril had the highest risk of cough (80.4%), while spirapril had the lowest (12.3%). ACEIs should be avoided in patients at risk of cough, and an ARB or CCB is a possible alternative.
Paper Details　
Original Abstract of the Article :
Studies have shown that angiotensin converting enzyme inhibitors (ACEIs) are superior in primary and secondary prevention for cardiac mortality and morbidity to angiotensin receptor blocker (ARBs). One of the common side effects from ACEI is dry cough. The aims of this systematic review, and network...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10423763/

データ提供：米国国立医学図書館（NLM）

Coughing Up the Truth: ACEIs and the Risk of Cough

Angiotensin-converting enzyme inhibitors (ACEIs), often used to treat hypertension, are known for their effectiveness in reducing cardiovascular risk. However, one common side effect of ACEIs is dry cough. This research aimed to assess the relative risk of cough induced by different ACEIs compared to placebo, ARBs, and calcium channel blockers (CCBs). They conducted a systematic review and network meta-analysis of 135 randomized controlled trials, analyzing the risk of cough in patients treated with various ACEIs. The analysis revealed that ACEIs were significantly more likely to cause cough than placebo, ARBs, and CCBs. It's like exploring a desert with different pathways, each with its own unique challenges and risks.

A Balanced Approach to Hypertension Treatment

This research provides valuable information for healthcare providers in choosing the most appropriate antihypertensive medication for their patients. It highlights the need to consider the potential side effects of ACEIs, particularly the risk of cough, and to weigh them against the benefits of the medication. This study emphasizes the importance of a balanced approach to hypertension treatment, considering both efficacy and tolerability.

Navigating the Desert of Antihypertensive Options

The findings of this research provide a roadmap for navigating the diverse landscape of antihypertensive options. It suggests that ACEIs should be avoided in patients with a high risk of cough, and that ARBs or CCBs might be preferable alternatives. The study emphasizes the importance of individualized treatment plans, tailored to the specific needs and preferences of the patient.

Dr.Camel's Conclusion

This research sheds light on the potential risks associated with ACEIs and the importance of choosing the right medication for each individual. It emphasizes the need for open communication between healthcare providers and patients to ensure safe and effective treatment.

Date :
  1. Date Completed 2023-08-15
  2. Date Revised 2023-08-16
Further Info :

Pubmed ID

37417783

DOI: Digital Object Identifier

PMC10423763

SNS
PICO Info
in preparation
Languages

English

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