Effects of moexipril: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Moexipril is an angiotensin-converting enzyme (ACE) inhibitor that has been shown to have a range of benefits for patients with hypertension and other cardiovascular conditions. Multiple studies have demonstrated its effectiveness in lowering blood pressure and improving metabolic function, including lipid and carbohydrate metabolism. 17 1 Moexipril has also been shown to reduce left ventricular hypertrophy (LVH), an important risk factor for cardiovascular disease. 11 Additionally, research suggests that moexipril may have positive effects on endothelial function, microcirculation, and renal function. 1 2 Furthermore, moexipril has been found to be safe and well-tolerated in clinical trials. 17 16 13

Benefits and Risks

Benefit Summary

Moexipril has shown effectiveness in treating hypertension and associated conditions. It has been demonstrated to lower blood pressure, improve lipid and carbohydrate metabolism, and reduce left ventricular hypertrophy. 17 1 11 22 In addition, moexipril has shown potential benefits for endothelial function, microcirculation, and renal function. 1 2 These benefits may contribute to improved cardiovascular health and reduced risks of complications associated with hypertension.

Risk Summary

While generally considered safe, moexipril can cause side effects, most commonly dry cough, dizziness, and headache. 8 It is important to note that moexipril may not be suitable for all individuals, particularly pregnant women or those with kidney problems. 16 It is crucial to discuss your medical history and any concerns with your doctor before taking moexipril.

Comparison Between Studies

Commonalities

Several studies consistently demonstrate the efficacy of moexipril in lowering blood pressure and improving cardiovascular health. Across these studies, moexipril has been shown to reduce blood pressure, improve metabolic function, and offer potential benefits for endothelial function, microcirculation, and renal function. 17 1 2 22 These findings suggest that moexipril may be a valuable treatment option for individuals with hypertension and related conditions.

Differences

While the studies consistently highlight moexipril's benefits in hypertension treatment, they also delve into various additional aspects. For example, moexipril has shown particular effectiveness in treating hypertension in postmenopausal women. 17 1 Studies have also explored the effects of moexipril on left ventricular hypertrophy, showing its potential to reduce this condition. 11 22 This variation in research focus suggests a broader spectrum of potential applications for moexipril in cardiovascular care.

Consistency and Discrepancies in Findings

Overall, the research on moexipril consistently indicates its effectiveness in treating hypertension and associated conditions. Moexipril has been shown to improve blood pressure, metabolic function, and cardiovascular health in various clinical trials. 17 1 11 22 However, it's essential to consider the potential for side effects, particularly dry cough, dizziness, and headache. 8 Furthermore, moexipril may not be appropriate for everyone, particularly pregnant women or those with kidney problems. 16

Considerations for Real-World Application

Moexipril has shown promise as a treatment for hypertension and associated conditions. It offers a potential solution for lowering blood pressure, improving metabolic function, and mitigating the risks associated with hypertension. 17 1 11 22 However, it is crucial to discuss any potential risks or concerns with your doctor before taking moexipril. They can provide personalized advice based on your individual medical history and needs.

Limitations of Current Research

While existing research provides valuable insights into moexipril's effectiveness, further research is needed to fully understand its long-term effects and potential benefits across various populations and conditions. Additional studies are also required to optimize dosage and treatment regimens for different patient groups.

Future Research Directions

Future research should focus on investigating the long-term effects of moexipril on cardiovascular health and its potential benefits for various patient groups. Further studies are necessary to establish optimal dosages and treatment regimens for different individuals, particularly those with specific comorbidities. This research can contribute to a more comprehensive understanding of moexipril's therapeutic potential and ensure its safe and effective use in clinical practice.

Conclusion

Moexipril has emerged as a promising treatment option for hypertension and associated conditions. 17 1 11 22 Its effectiveness in lowering blood pressure, improving metabolic function, and potentially reducing the risks of cardiovascular complications is supported by multiple studies. 17 11 22 However, it is crucial to discuss potential side effects and your medical history with your doctor before taking moexipril. Continued research will further elucidate its therapeutic potential and refine its use in clinical settings.

Literature analysis of 22 papers
Positive Content
22
Neutral Content
0
Negative Content
0
Article Type
1
1
1
4
22
1.

[Hypotensive, organoprotective, and metabolic effects of Angiotensin converting enzyme inhibitor moexipril in women with postmenopausal syndrome].

Author: LeonovaM V, DemidovaM A, TarasovA V, BelousovIu B

Improved lipid profile
Improved vasodilation
Lower BP
Reduced proteinuria

Moexipril, an angiotensin-converting enzyme inhibitor, effectively lowered blood pressure and improved vasodilating function in postmenopausal women with metabolic syndrome and hypertension. It also reduced total cholesterol, LDL cholesterol, and triglycerides in patients with obesity.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

2.

[Hemodynamic and anti-ischemic effects of moexipril in patients having postinfarction heart dysfunction and moderate left ventricular heart failure].

Author: TepliakovA T, Pchel'nikovA V, GarganeevaA A, KrivonogovN G

Improved LV ejection fraction
Improved microcirculation
Increased activity tolerance
Reduced stenocardia

This study evaluated hemodynamic and anti-ischemic effects of moexipril in patients with postinfarction left ventricular dysfunction (PL VD) and moderate left ventricular heart failure (NYHA functional class II-III).

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

3.

ACE Inhibition with moexipril: a review of potential effects beyond blood pressure control.

Author: PinesAmos, FismanEnrique Z

Bone metabolism improvement
Endothelial dysfunction improvement
Hypertension treatment
Neuroprotective effect
Renal insufficiency treatment

Moexipril is an ACE inhibitor that has been shown to have a variety of beneficial effects in animal studies, including improved endothelial function, neuroprotection, and renoprotection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

Antihypertensive effects of moexipril, a new ACE inhibitor, as add-on therapy to nifedipine in patients with essential hypertension.

Author: PerssonB, WidgrenB R, FoxA, StimpelM

Moexipril effective
Moexipril safe

Moexipril, an ACE inhibitor, was well tolerated and provided additional antihypertensive effects when added to nifedipine retard in patients with essential hypertension. All doses of moexipril (3.75 mg, 7.5 mg, and 15 mg) reduced diastolic blood pressure significantly compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis.

Author: HuYiyun, LiangLing, LiuShuang, KungJanice Y, BanhHoan Linh

Cardiac mortality and morbidity prevention
Dry cough

Angiotensin converting enzyme inhibitors (ACEIs) are known to cause dry cough. This systematic review and network meta-analysis ranked the risk of cough induced by different ACEIs and compared them to placebo, ARB, or CCB. Moexipril had the highest risk of cough (80.4%), while spirapril had the lowest (12.3%). ACEIs should be avoided in patients at risk of cough, and an ARB or CCB is a possible alternative.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).

Author: CameronRyan T, ColemanRyan G, DayJon P, YallaKrishna C, HouslayMiles D, AdamsDavid R, ShoichetBrian K, BaillieGeorge S

PDE4 inhibition

Moexipril, an angiotensin-converting enzyme (ACE) inhibitor, was identified as a PDE4 inhibitor. Moexipril and its analogues inhibited PDE4 activity in the micro molar range, increased intracellular cAMP levels, and induced phosphorylation of the small heat shock protein, Hsp20. This suggests that moexipril may be a potential starting point for the development of novel PDE4 inhibitors with improved therapeutic window.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Effect of RAS inhibition on TGF-β, renal function and structure in experimentally induced diabetic hypertensive nephropathy rats.

Author: MohamedR H, Abdel-AzizH R, Abd El MottelebD M, Abd El-AzizT A

Improved renal function
Reduced fibrosis

Addition of the spironolactone to moexpril was more effective in reducing fibrosis and improvement of renal function than monotherapy with either drug.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Moexipril and left ventricular hypertrophy.

Author: ChrysantGeorge S, NguyenP K

LVH regression

Moexipril hydrochloride, a long-acting ACE inhibitor, can lead to regression of left ventricular hypertrophy (LVH). This beneficial effect extends beyond simple blood pressure reduction and highlights its potential role in managing cardiovascular disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Metabolism of moexipril to moexiprilat: determination of in vitro metabolism using HPLC-ES-MS.

Author: KalászH, PetroianuG, TekesK, KlebovichI, LudányiK, GulyásZs

Treat arterial hypertension

This study investigated the metabolism of moexipril in rat and human microsomal preparations. Moexiprilat, the active metabolite, was produced more efficiently in rat liver microsomes than in human liver cell lines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

[Angiotensin converting enzyme inhibitor moexipril in the treatment of arterial hypertension. Possibilities of moexipril in the treatment of postmenopausal women].

Author: OstroumovaO D, PaukovS V, FrolovaL I

Bone metabolism improvement
Hypertension treatment
Side effects

This review examines the efficacy and safety of moexipril, an angiotensin-converting enzyme inhibitor, for the treatment of arterial hypertension. The authors discuss the advantages of moexipril, including its 24-hour duration of action, metabolic neutrality, and low rate of side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Russian

16.

[Moexipril and cardiovascular diseases in women: is there a reason for optimism?].

Author:

Antihypertensive
CHF treatment

This study discusses the use of angiotensin converting enzyme (ACE) inhibitors in the treatment of chronic heart failure. It highlights the evidence that ACE inhibitors may exert less pronounced favorable prognostic influence in women compared with men. The study suggests that further research on the efficacy of moexipril in chronic heart failure in women may broaden the indications for its use.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Russian

17.

[Comparative efficacy and safety of contemporary Angiotensin converting enzyme inhibitors moexipril and spirapril in women with postmenopausal metabolic syndrome].

Author: LeonovaM V, DemidovaM A, TarasovA V, BelousovIu B

Hypertension treatment
Metabolic syndrome treatment

This study examined the use of moexipril and spirapril for the treatment of hypertension in patients with postmenopausal metabolic syndrome.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

18.

[Moexipril influence on quality of life in postmenopausal women with arterial hypertension].

Author: BelousovIu B, GlezerM G, TkhostovaE B, DemidovaM A

Improve endothelial function
Improve quality of life
Lower BP

Moexipril was studied in postmenopausal women with arterial hypertension. Moexipril was effective in lowering blood pressure and improving endothelial function and quality of life in these women. It was also found to be safe and did not affect lipid or carbohydrate metabolism.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

19.

Subchronic exposure to high-dose ACE-inhibitor moexipril induces catalase activity in rat liver.

Author: AdeghateE, HasanM Y, PoneryA S, NurulainS M, PetroianuG A

Antioxidant activity
Blood pressure reduction

This study investigated the effects of moexipril, an ACE inhibitor, on catalase activity in rat liver. Moexipril increased catalase activity to an extent similar to clofibrate, a known PPAR agonist. These findings suggest that some of the long-term benefits of ACE inhibitors might be mediated through PPAR activation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

[The use of moexipril in postmenopausal women with hypertension and associated changes of bone mineral density].

Author: KirichenkoA A, Demel'khanovaT S, RiazantsevA A, NovichkovaIu N, EbzeevaE Iu, IurchenkoK V

Improved bone density
Improved quality of life
Lowered BP
Menopausal syndrome relief
Reduced anxiety and depression

This study investigated the effects of moexipril, an angiotensin-converting enzyme inhibitor, on blood pressure, menopausal symptoms, and bone mineral density in postmenopausal women. The study found that moexipril significantly reduced blood pressure and menopausal symptoms, and improved bone mineral density after 12 months of treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

21.

MORE--MOexipril and REgression of left ventricle hypertrophy in combination therapy A multicentric open label clinical trial.

Author: SpinarJ, VítovecJ,

Improved left ventricular function
Reduced blood pressure
Reduced cholesterol levels
Reduced triglyceride levels
Cough

The ACE inhibitor moexipril added to combination therapy for hypertension had a similar effect on blood pressure reduction and left ventricle mass as in monotherapy trials. The most effective combination was ACE inhibitor plus thiazide diuretic.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : English

22.

Regression of left ventricular hypertrophy with moexipril, an angiotensin-converting enzyme inhibitor, in hypertensive patients.

Author: SayeghFady, TopouchianJirar, HlawatyMarta, OlzewskaMaria, AsmarRoland

BP reduction
LVH regression

This study evaluated the effect of moexipril, an ACE inhibitor, on regression of left ventricular hypertrophy (LVH) in hypertensive patients. Moexipril significantly reversed LVH, comparable to previous findings with other ACE inhibitors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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