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Comparative effects of d-amphetamine, l-amphetamine, and methylphenidate on mood in man.

Author: DavisJ M, SmithR C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

d-amphetamine is more potent than l-amphetamine, while methylphenidate has an intermediate effect.
Paper Details　
Original Abstract of the Article :
The comparative effects of d-amphetamine, l-amphetamine, and methylphenidate were assessed in 16 normal subjects, using a double-blind, crossover placebo-controlled design. Within the dose range tested, the efficacy ratio of d-amphetamine:l-amphetamine was about 2:1, and graphic presentation of dose...See full text at original site
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引用元：
https://doi.org/10.1007/BF00426687

データ提供：米国国立医学図書館（NLM）

Mood Enhancement: A Desert of Chemical Interactions

This study delves into the comparative effects of d-amphetamine, l-amphetamine, and methylphenidate on mood in humans. Imagine a traveler venturing through a desert of chemical interactions, where the effects of different substances can vary greatly. Similarly, our brains are complex chemical factories, and the introduction of psychoactive drugs can have a wide range of effects on mood, behavior, and cognition. This research explores the impact of these three stimulants on mood, providing valuable insights into their mechanisms of action.

Amphetamines and Methylphenidate: Exploring the Terrain of Mood Enhancement

The study found that d-amphetamine was more potent than l-amphetamine in enhancing euphoric mood, with methylphenidate falling somewhere in between. This suggests that the different isomers of amphetamine, as well as methylphenidate, interact with the brain in distinct ways, leading to varying effects on mood. These findings highlight the importance of understanding the individual characteristics and mechanisms of action of these psychoactive substances.

Navigating the Desert of Psychoactive Substances: A Cautionary Tale

The study emphasizes the potential for both therapeutic and adverse effects of these stimulants. Dr. Camel believes that it's essential to use these medications responsibly and under the guidance of a qualified healthcare professional. Understanding the complex interactions between these substances and the brain is crucial for maximizing their benefits and minimizing potential risks.

Dr.Camel's Conclusion

This study offers valuable insights into the effects of d-amphetamine, l-amphetamine, and methylphenidate on mood. Dr. Camel believes that by carefully navigating the desert of psychoactive substances, we can leverage their potential benefits while minimizing potential risks, ensuring the well-being of those who use them.

Date :
  1. Date Completed 1977-09-29
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

407607

DOI: Digital Object Identifier

10.1007/BF00426687

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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