Angiotensin converting enzyme during acute and chronic enalapril therapy in essential hypertension.

Author: JacksonB, JohnstonC I

Paper Details 
Original Abstract of the Article :
The acute and chronic effects of enalapril (MK421) were assessed in a double-blind randomized trial in subjects with essential hypertension. In acute studies, twelve subjects received enalapril (10 mg p.o.), following which there was a fall in blood pressure, maximal at 6 h and lasting for 24 h. Ser...See full text at original site
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引用元:
https://doi.org/10.1111/j.1440-1681.1984.tb00278.x

データ提供:米国国立医学図書館(NLM)

Angiotensin Converting Enzyme: A Complex Desert Landscape

The renin-angiotensin system (RAS) plays a vital role in regulating blood pressure and fluid balance in the body. It's like a complex desert ecosystem, with various interconnected elements working together to maintain equilibrium.

This study investigated the effects of enalapril, an angiotensin-converting enzyme (ACE) inhibitor, on blood pressure and ACE activity in patients with essential hypertension. Researchers aimed to understand the [main objective] of enalapril, particularly its acute and chronic effects on the RAS.

The study found that enalapril effectively inhibited ACE activity, leading to a reduction in blood pressure. However, chronic treatment resulted in an induction of ACE, suggesting that the body adapts to long-term ACE inhibition. The key findings include [key findings], highlighting the complex dynamics of the RAS and the need for tailored treatment strategies.

Navigating the Desert of Hypertension

This study provides valuable insights into the complex mechanisms underlying hypertension and the potential benefits of ACE inhibitors like enalapril. It's like understanding the intricate workings of a desert ecosystem and how to manage its resources effectively.

Finding Balance in the Desert of Blood Pressure

This research reminds us that the body's regulatory systems are dynamic and adaptable. It's like navigating a desert landscape, where maintaining balance requires constant adjustments and understanding of the environment.

Dr. Camel's Conclusion

This study underscores the importance of ongoing research into the complex interplay between drugs and the body's regulatory systems. It's like exploring a vast desert, where each discovery leads to a deeper understanding of the intricate mechanisms of life.

Date :
  1. Date Completed 1985-03-07
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

6097377

DOI: Digital Object Identifier

10.1111/j.1440-1681.1984.tb00278.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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