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Role of loperamide and placebo in management of irritable bowel syndrome (IBS).

Author: BarendsD, CannP A, HoldsworthC D, ReadN W

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 28 patients with irritable bowel syndrome found that loperamide was more effective than placebo in relieving symptoms, accelerating gastric emptying, and delaying intestinal transit.
Paper Details　
Original Abstract of the Article :
Symptom scores, stool data, and the transit of a standard, solid meal were measured in 28 patients with irritable bowel syndrome (IBS) during baseline conditions and after five weeks of treatment with placebo and loperamide, given as a flexible dosage regime in the form of a double-blind, cross-over...See full text at original site
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引用元：
https://doi.org/10.1007/BF01296258

データ提供：米国国立医学図書館（NLM）

Loperamide: A Potential Treatment for Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is a common gastrointestinal disorder that can significantly impact individuals' quality of life. This research investigates the role of loperamide, an anti-diarrheal medication, in managing IBS symptoms. The study evaluated the effects of loperamide compared to placebo in a double-blind, cross-over trial.

Loperamide Shows Potential in Managing IBS Symptoms

The study found that loperamide accelerated gastric emptying and delayed both small bowel and whole gut transit in patients with IBS. The results also suggested that loperamide was effective in reducing symptoms such as diarrhea, urgency, and borborygmi. These findings highlight the potential of loperamide as a treatment option for IBS, particularly for those experiencing diarrhea-predominant IBS.

Navigating the Desert of IBS: Finding Relief Through Treatment

This research offers a potential avenue for managing IBS symptoms, particularly for those experiencing diarrhea. However, it's crucial to remember that IBS is a complex condition, and the best treatment approach may vary depending on the individual. If you're experiencing IBS symptoms, consult your doctor to determine the most appropriate treatment plan for your needs.

Dr.Camel's Conclusion

IBS can feel like a relentless desert wind, causing discomfort and disrupting daily life. This research offers a potential tool to help manage the symptoms of this common condition. While more research is needed, it provides a glimmer of hope for those seeking relief from IBS. Remember, your journey through IBS is unique, and seeking professional guidance is essential to finding the best approach for managing your symptoms.

Date :
  1. Date Completed 1984-04-10
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

6365490

DOI: Digital Object Identifier

10.1007/BF01296258

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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