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Single-blind study of the effects of intravenous dolasetron mesylate versus ondansetron on electrocardiographic parameters in normal volunteers.

Author: ArbogastR, BenedictC R, HahneW, MartinL, MorrillB, PattonL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the effects of intravenous dolasetron mesylate on electrocardiogram (ECG) intervals in healthy volunteers. Dolasetron mesylate and ondansetron both prolonged the QTc interval, but dolasetron mesylate primarily affected ventricular depolarization, while ondansetron mainly affected ventricular repolarization.
Paper Details　
Original Abstract of the Article :
A single-blind, randomized, five-way cross-over, safety and tolerability trial was conducted to determine whether intravenous (i.v.) dolasetron mesylate at varying single doses induces changes in ECG intervals in healthy volunteers and to compare these changes with a single intravenous dose of ondan...See full text at original site
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引用元：
https://doi.org/10.1097/00005344-199607000-00009

データ提供：米国国立医学図書館（NLM）

A Rhythmic Dance: Comparing Dolasetron and Ondansetron's Effects on the Heart

Nausea and vomiting, common side effects of chemotherapy, can significantly impact patients' quality of life. This study compares the effects of two antiemetic medications, dolasetron mesylate and ondansetron, on electrocardiographic parameters in healthy volunteers. The researchers meticulously monitored the participants' ECG readings after receiving intravenous doses of these medications, seeking to understand their impact on heart rhythm and electrical activity.

A Heartbeat of Change: Electrocardiographic Effects of Dolasetron and Ondansetron

The study found that both dolasetron mesylate and ondansetron produced transient, asymptomatic changes in ECG intervals, primarily affecting the QT interval, a measure of ventricular repolarization. Dolasetron mesylate, however, predominantly altered parameters indicative of ventricular depolarization (QRS duration), while ondansetron primarily affected ventricular repolarization as measured by a prolongation in the JT interval. This research, like a careful camel navigator observing subtle shifts in the desert landscape, highlights the nuanced differences in the effects of these two antiemetic medications.

A Balancing Act: Understanding the Risks and Benefits

This study, like a desert oasis providing respite for weary travelers, reminds us of the importance of understanding the potential risks and benefits of medications, particularly when it comes to their impact on vital functions like heart rhythm. While both dolasetron mesylate and ondansetron effectively manage nausea and vomiting, this research underscores the need for careful monitoring and consideration of individual patient factors when choosing an antiemetic agent.

Dr. Camel's Conclusion

This study, like a caravan navigating a challenging desert, highlights the importance of understanding the nuanced effects of medications on the heart. It reminds us that even seemingly routine interventions can have subtle impacts on vital functions, requiring careful consideration and monitoring to ensure patient safety.
Date :
  1. Date Completed 1997-01-06
  2. Date Revised 2019-07-24
Further Info :

Pubmed ID

8797136

DOI: Digital Object Identifier

10.1097/00005344-199607000-00009

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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