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Concentration-related pharmacodynamic effects of thioridazine and its metabolites in humans.

Author: BatemanD N, Hartigan-GoK, MårtenssonE, NybergG, ThomasS H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Thioridazine, in doses of 50 mg and 10 mg, was shown to have a dose-related effect on ventricular repolarization. The parent drug was responsible for a significant portion of these effects, with possible contributions from its metabolites.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To measure cardiac and other effects of thioridazine and relate these to the plasma concentration of the parent drug and its principal metabolites. METHODS: A double-blind, randomized-order crossover study involving nine healthy male subjects compared the effects of single doses of thior...See full text at original site
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引用元：
https://doi.org/10.1016/S0009-9236(96)90150-2

データ提供：米国国立医学図書館（NLM）

Thioridazine's Effects: A Concentration-Related Dance of Cardiac and Psychomotor Changes

Thioridazine, a drug often used to treat certain mental health conditions, can have a variety of effects on the body. This study explores the concentration-dependent effects of thioridazine and its metabolites on the heart, blood pressure, and psychomotor function in healthy individuals. The researchers administered varying doses of thioridazine and meticulously monitored its impact, finding a dose-related effect on heart rate, blood pressure, and psychomotor function. These findings provide valuable insights into the complex interplay between thioridazine and its effects on the body.

Unraveling the Dance of thioridazine's Effects

The research reveals that thioridazine's effects are closely tied to its concentration in the body. Higher doses lead to more pronounced changes in heart rate, blood pressure, and psychomotor function. The study provides valuable insights into the dose-dependent effects of thioridazine, emphasizing the importance of careful monitoring and dosage adjustments. The study also highlights the potential for thioridazine to affect the heart's electrical activity, potentially influencing heart rhythm.

A Balancing Act: Thioridazine's Effects on the Heart

This research offers a glimpse into the complex interplay between thioridazine and the heart. Understanding the potential for thioridazine to affect heart rate, blood pressure, and electrical activity is crucial for ensuring patient safety. It's like navigating a delicate balance between the calming effects of thioridazine and its potential impact on the heart's rhythm. It’s crucial to monitor patients closely to ensure they’re receiving the right dose to manage their condition while minimizing the risk of complications.

Dr.Camel's Conclusion

Thioridazine's effects on the body are like a swirling sandstorm – complex and unpredictable. This research helps us better understand how this drug interacts with the heart and the importance of precise dosing. Think of it as a delicate dance between calming the mind and maintaining a steady heart rhythm. By understanding these complexities, we can better navigate the desert of mental health care and provide safe and effective treatments.

Date :
  1. Date Completed 1996-12-19
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

8941027

DOI: Digital Object Identifier

10.1016/S0009-9236(96)90150-2

SNS
PICO Info
in preparation
Languages

English

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