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Overview and meta-analysis of randomised trials of amiodarone in chronic heart failure.

Author: CoatsA J, FlatherM D, PiepoliM, PonikowskiP, VillaniG Q, WrightA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This article reviews the use of amiodarone in patients with heart failure. While meta-analysis suggests a significant reduction in deaths, it also highlights a significant increase in side effects associated with amiodarone use.
Paper Details　
Original Abstract of the Article :
Unlike other antiarrhythmic class I drugs, amiodarone showed in preliminary studies, benefits also in patients with left ventricular dysfunction. These positive results have induced the development of large randomised controlled studies: their results are reviewed and the controversial points are di...See full text at original site
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引用元：
https://doi.org/10.1016/s0167-5273(98)00184-3

データ提供：米国国立医学図書館（NLM）

Amiodarone for Chronic Heart Failure: A Balancing Act of Benefits and Risks

Amiodarone, a medication used to treat irregular heart rhythms, has also shown promise in managing chronic heart failure. This study delves into the effectiveness of amiodarone for this condition by conducting a meta-analysis of randomized controlled trials. The analysis revealed that amiodarone was associated with a significant reduction in mortality among patients with heart failure, but also with a substantial increase in adverse effects.

A Double-Edged Sword: The Benefits and Risks of Amiodarone

The meta-analysis revealed a 20-25% reduction in deaths in patients with heart failure who received amiodarone, suggesting a potential survival benefit. However, this was offset by a 120-124% increase in side effects, highlighting the importance of careful risk-benefit assessment when considering amiodarone therapy.

Weighing the Options: Balancing Benefits and Risks

This study serves as a reminder that even with promising therapeutic options, there is always a need to carefully weigh the benefits against the risks. For individuals with chronic heart failure, discussing the potential advantages and drawbacks of amiodarone with their healthcare provider is crucial to making informed decisions about their treatment.

Dr.Camel's Conclusion

This study is like a double-humped camel - it offers both benefits and risks. Amiodarone can be a valuable tool for managing heart failure, but it's important to understand the potential side effects and to make informed decisions with your healthcare provider.

Date :
  1. Date Completed 1998-12-16
  2. Date Revised 2019-08-16
Further Info :

Pubmed ID

9781781

DOI: Digital Object Identifier

10.1016/s0167-5273(98)00184-3

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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