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Pharmacodynamic effects of single doses of rabeprazole 20 mg and pantoprazole 40 mg in patients with GERD and nocturnal heartburn.

Author: BaisleyK, BoyceM, DelemosB, LeeD, LomaxK, MorocuttiA, WarringtonS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This open-label, randomized, two-way crossover, clinical pharmacology study compared the antisecretory effects of single doses of rabeprazole and pantoprazole in patients with GERD and a history of nocturnal heartburn. The study found that a single oral dose of rabeprazole 20 mg increased intragastric pH more than pantoprazole 40 mg did throughout the 24 h after dosing.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Rabeprazole and pantoprazole are both used for symptomatic treatment of gastro-oesophageal reflux disease (GERD). Speed and duration of acid suppression and intensity of effect after a single dose may be important pharmacodynamic properties in clinical use. AIM: To compare antisecretory...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2006.03196.x

データ提供：米国国立医学図書館（NLM）

Pharmacodynamic Effects of Single Doses of Rabeprazole 20 mg and Pantoprazole 40 mg in Patients with GERD and Nocturnal Heartburn

This study delves into the realm of gastroenterology, specifically comparing the pharmacodynamic effects of two proton pump inhibitors (PPIs), rabeprazole and pantoprazole, in patients experiencing gastroesophageal reflux disease (GERD) and nocturnal heartburn. The researchers aimed to evaluate the speed, duration, and intensity of acid suppression following a single dose of each medication.

Effective Management of Heartburn

The study suggests that a single dose of rabeprazole 20 mg is more effective in increasing intragastric pH compared to a single dose of pantoprazole 40 mg, particularly during the nighttime hours. These findings offer valuable insights for clinicians in selecting the most appropriate PPI for treating GERD and nocturnal heartburn.

Finding Relief from Heartburn

The study's results provide valuable information for patients experiencing GERD and nocturnal heartburn. It suggests that rabeprazole may be a more effective option for providing nighttime relief from symptoms.

Dr. Camel's Conclusion

This research, like a skilled chef adjusting the acidity of a dish, meticulously compares the effects of different PPIs on gastric acid suppression. It highlights the importance of choosing the right PPI for effective management of GERD and nocturnal heartburn.
Date :
  1. Date Completed 2007-11-02
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

17270007

DOI: Digital Object Identifier

10.1111/j.1365-2036.2006.03196.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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