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Human abuse liability of the smoking cessation drug varenicline in smokers and nonsmokers.

Author: BillingC B, BursteinA H, McCollS L, ReevesK R, SellersE M, StolarM

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Varenicline, a medication to help people stop smoking, is unlikely to be abused. This was demonstrated in a study where smokers and nonsmokers were given varenicline or a placebo. Varenicline did not produce the same pleasurable effects as amphetamine, a known drug of abuse. Additionally, varenicline was associated with some unpleasant effects.
Paper Details　
Original Abstract of the Article :
Varenicline is an alpha(4)beta(2) nicotinic acetylcholine receptor partial agonist developed as an aid for smoking cessation. This study evaluated varenicline's potential for abuse by smokers (n = 23) and nonsmokers (n = 22). The study used a randomized, double-blind, placebo-controlled, double-dumm...See full text at original site
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引用元：
https://doi.org/10.1038/sj.clpt.6100510

データ提供：米国国立医学図書館（NLM）

Varenicline: A Smoking Cessation Aid with Low Abuse Potential

Varenicline is a medication designed to help smokers quit. This study evaluated the potential for varenicline to be abused, a concern often raised with medications that interact with the brain's reward system.

A Clear Path to Quitting: Varenicline's Low Abuse Potential

The research, using a rigorous study design, found that varenicline showed no significant potential for abuse, even in smokers and non-smokers. This finding offers reassurance to patients and healthcare providers, demonstrating that varenicline's benefits in helping people quit smoking outweigh its potential for misuse. This is like a desert traveler finding a reliable and safe oasis for rest and refreshment—a welcome relief from the dangers of the desert.

Choosing a Quitting Path: Seeking Expert Guidance

For individuals seeking to quit smoking, varenicline can be a valuable tool, especially considering its low abuse potential. It's essential to consult with a healthcare professional to discuss the risks and benefits of varenicline and to create a personalized quitting plan. This collaborative approach can increase the likelihood of successful smoking cessation.

Dr. Camel's Conclusion

This study offers valuable insights into the safety and efficacy of varenicline as a smoking cessation aid. Its low abuse potential makes it a valuable option for individuals looking to break free from nicotine addiction. This is a testament to the power of scientific research, like a camel navigating a desert with a reliable compass to guide their journey.
Date :
  1. Date Completed 2008-03-26
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

18288085

DOI: Digital Object Identifier

10.1038/sj.clpt.6100510

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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